FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22903

FusionGeneSummary for MVB12B_MED27

check button Fusion gene summary
Fusion gene informationFusion gene name: MVB12B_MED27
Fusion gene ID: 22903
HgeneTgene
Gene symbol

MVB12B

MED27

Gene ID

89853

9442

Gene namemultivesicular body subunit 12Bmediator complex subunit 27
SynonymsC9orf28|FAM125BCRAP34|CRSP34|CRSP8|MED3|TRAP37
Cytomap

9q33.3

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionmultivesicular body subunit 12BESCRT-I complex subunit MVB12Bfamily with sequence similarity 125, member Bmediator of RNA polymerase II transcription subunit 27CRSP complex subunit 8cofactor required for Sp1 transcriptional activation, subunit 8, 34kDap37 TRAP/SMCC/PC2 subunittranscriptional coactivator CRSP34
Modification date2018052220180519
UniProtAcc

Q9H7P6

Q6P2C8

Ensembl transtripts involved in fusion geneENST00000545391, ENST00000361171, 
ENST00000436593, ENST00000535766, 
ENST00000485886, 
ENST00000357028, 
ENST00000292035, ENST00000474263, 
Fusion gene scores* DoF score7 X 8 X 3=1684 X 6 X 6=144
# samples 108
** MAII scorelog2(10/168*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MVB12B [Title/Abstract] AND MED27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMED27

GO:0006357

regulation of transcription by RNA polymerase II

9989412


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EB-A24D-01AMVB12Bchr9

129102909

+MED27chr9

134889854

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000545391ENST00000357028MVB12Bchr9

129102909

+MED27chr9

134889854

-
In-frameENST00000545391ENST00000292035MVB12Bchr9

129102909

+MED27chr9

134889854

-
5CDS-intronENST00000545391ENST00000474263MVB12Bchr9

129102909

+MED27chr9

134889854

-
In-frameENST00000361171ENST00000357028MVB12Bchr9

129102909

+MED27chr9

134889854

-
In-frameENST00000361171ENST00000292035MVB12Bchr9

129102909

+MED27chr9

134889854

-
5CDS-intronENST00000361171ENST00000474263MVB12Bchr9

129102909

+MED27chr9

134889854

-
In-frameENST00000436593ENST00000357028MVB12Bchr9

129102909

+MED27chr9

134889854

-
In-frameENST00000436593ENST00000292035MVB12Bchr9

129102909

+MED27chr9

134889854

-
5CDS-intronENST00000436593ENST00000474263MVB12Bchr9

129102909

+MED27chr9

134889854

-
intron-3CDSENST00000535766ENST00000357028MVB12Bchr9

129102909

+MED27chr9

134889854

-
intron-3CDSENST00000535766ENST00000292035MVB12Bchr9

129102909

+MED27chr9

134889854

-
intron-intronENST00000535766ENST00000474263MVB12Bchr9

129102909

+MED27chr9

134889854

-
intron-3CDSENST00000485886ENST00000357028MVB12Bchr9

129102909

+MED27chr9

134889854

-
intron-3CDSENST00000485886ENST00000292035MVB12Bchr9

129102909

+MED27chr9

134889854

-
intron-intronENST00000485886ENST00000474263MVB12Bchr9

129102909

+MED27chr9

134889854

-

Top

FusionProtFeatures for MVB12B_MED27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MVB12B

Q9H7P6

MED27

Q6P2C8

Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:10882111,ECO:0000269|PubMed:9989412}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMVB12Bchr9:129102909chr9:134889854ENST00000361171+210254_30368320DomainUMA
HgeneMVB12Bchr9:129102909chr9:134889854ENST00000361171+21047_19368320DomainMABP
HgeneMVB12Bchr9:129102909chr9:134889854ENST00000545391+26254_30368222DomainUMA
HgeneMVB12Bchr9:129102909chr9:134889854ENST00000545391+2647_19368222DomainMABP


Top

FusionGeneSequence for MVB12B_MED27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_228aa
MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN
QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVR

>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_264aa
MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN
QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKL

>In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_228aa
MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN
QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVR

>In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_264aa
MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN
QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKL

>In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_213aa
MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPT
TLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQA

>In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_249aa
MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPT
TLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_684nt
ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC
ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC
CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT
CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC
ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCC
AACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGA
TCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCG

>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_792nt
ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC
ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC
CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT
CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC
ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTG
AAAGTGATCGTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTT
GATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATG
CCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTG

>In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_684nt
ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC
ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC
CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT
CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC
ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCC
AACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGA
TCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCG

>In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_792nt
ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC
ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC
CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT
CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC
ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTG
AAAGTGATCGTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTT
GATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATG
CCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTG

>In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_639nt
ATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACG
TCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTA
GCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACA
ACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCC
AATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCC
CTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCC
CCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGC

>In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_747nt
ATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACG
TCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTA
GCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACA
ACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCC
AATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATCGTCGTCATGCGGAGCCTGTTCATTGATCGAACAATA
GTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACA
GACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTAC
ATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_1196nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA
GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG
ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAA
GTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATG
ACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGG
GATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCCCACCCAGCACCTTCCCA
GACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTCATAAAGCAGCGCCATGT
GTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGACTGAAGGCAAAGAAGAC
CTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTGTCGTCTCCGCGAGCTGT
TACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGGTAACTTATTTTTATAAG

>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_1304nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA
GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG
ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATC
GTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGG
TCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTC
GTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGC
CTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACC
CCACCCAGCACCTTCCCAGACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTT
CATAAAGCAGCGCCATGTGTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGG
ACTGAAGGCAAAGAAGACCTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCT
GTCGTCTCCGCGAGCTGTTACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTG

>In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_1196nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA
GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG
ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAA
GTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATG
ACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGG
GATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCCCACCCAGCACCTTCCCA
GACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTCATAAAGCAGCGCCATGT
GTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGACTGAAGGCAAAGAAGAC
CTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTGTCGTCTCCGCGAGCTGT
TACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGGTAACTTATTTTTATAAG

>In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_1304nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA
GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG
ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATC
GTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGG
TCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTC
GTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGC
CTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACC
CCACCCAGCACCTTCCCAGACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTT
CATAAAGCAGCGCCATGTGTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGG
ACTGAAGGCAAAGAAGACCTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCT
GTCGTCTCCGCGAGCTGTTACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTG

>In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_1195nt
AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG
CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG
AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA
CAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAG
TATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGA
TGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAAG
TATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATGA
CCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGG
ATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCCCACCCAGCACCTTCCCAG
ACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTCATAAAGCAGCGCCATGTG
TGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGACTGAAGGCAAAGAAGACC
TTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTGTCGTCTCCGCGAGCTGTT
ACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGGTAACTTATTTTTATAAGC

>In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_1303nt
AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG
CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG
AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA
CAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAG
TATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGA
TGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATCG
TCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGGT
CCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCG
TGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCC
TTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCC
CACCCAGCACCTTCCCAGACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTC
ATAAAGCAGCGCCATGTGTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGA
CTGAAGGCAAAGAAGACCTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTG
TCGTCTCCGCGAGCTGTTACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGG


Top

FusionGenePPI for MVB12B_MED27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MVB12BTSG101, VPS37A, MVB12A, LNX1, METTL15, ITM2C, FEM1B, PLCG1, SLC25A41, VPS28MED27MED10, MED9, MED29, MED19, MED28, MED26, MED30, MED22, MED1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, MED14, MED4, FBXW7, EPAS1, POLR2C, ARFGAP1, AFP, RBPJ, SOX5, CDK8, CDK19, ESR1, MED7, CCNC, MED16, MED17, MED11, MED13, MED13L, MED15, MED20, MED24, MED6, MED8, MED23, MED21


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MVB12B_MED27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MVB12B_MED27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource