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Fusion gene ID: 22903 |
FusionGeneSummary for MVB12B_MED27 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MVB12B_MED27 | Fusion gene ID: 22903 | Hgene | Tgene | Gene symbol | MVB12B | MED27 | Gene ID | 89853 | 9442 |
Gene name | multivesicular body subunit 12B | mediator complex subunit 27 | |
Synonyms | C9orf28|FAM125B | CRAP34|CRSP34|CRSP8|MED3|TRAP37 | |
Cytomap | 9q33.3 | 9q34.13 | |
Type of gene | protein-coding | protein-coding | |
Description | multivesicular body subunit 12BESCRT-I complex subunit MVB12Bfamily with sequence similarity 125, member B | mediator of RNA polymerase II transcription subunit 27CRSP complex subunit 8cofactor required for Sp1 transcriptional activation, subunit 8, 34kDap37 TRAP/SMCC/PC2 subunittranscriptional coactivator CRSP34 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9H7P6 | Q6P2C8 | |
Ensembl transtripts involved in fusion gene | ENST00000545391, ENST00000361171, ENST00000436593, ENST00000535766, ENST00000485886, | ENST00000357028, ENST00000292035, ENST00000474263, | |
Fusion gene scores | * DoF score | 7 X 8 X 3=168 | 4 X 6 X 6=144 |
# samples | 10 | 8 | |
** MAII score | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MVB12B [Title/Abstract] AND MED27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MED27 | GO:0006357 | regulation of transcription by RNA polymerase II | 9989412 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-EB-A24D-01A | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000545391 | ENST00000357028 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
In-frame | ENST00000545391 | ENST00000292035 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
5CDS-intron | ENST00000545391 | ENST00000474263 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
In-frame | ENST00000361171 | ENST00000357028 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
In-frame | ENST00000361171 | ENST00000292035 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
5CDS-intron | ENST00000361171 | ENST00000474263 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
In-frame | ENST00000436593 | ENST00000357028 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
In-frame | ENST00000436593 | ENST00000292035 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
5CDS-intron | ENST00000436593 | ENST00000474263 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
intron-3CDS | ENST00000535766 | ENST00000357028 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
intron-3CDS | ENST00000535766 | ENST00000292035 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
intron-intron | ENST00000535766 | ENST00000474263 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
intron-3CDS | ENST00000485886 | ENST00000357028 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
intron-3CDS | ENST00000485886 | ENST00000292035 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
intron-intron | ENST00000485886 | ENST00000474263 | MVB12B | chr9 | 129102909 | + | MED27 | chr9 | 134889854 | - |
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FusionProtFeatures for MVB12B_MED27 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MVB12B | MED27 |
Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. | Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:10882111,ECO:0000269|PubMed:9989412}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MVB12B | chr9:129102909 | chr9:134889854 | ENST00000361171 | + | 2 | 10 | 254_303 | 68 | 320 | Domain | UMA |
Hgene | >MVB12B | chr9:129102909 | chr9:134889854 | ENST00000361171 | + | 2 | 10 | 47_193 | 68 | 320 | Domain | MABP |
Hgene | >MVB12B | chr9:129102909 | chr9:134889854 | ENST00000545391 | + | 2 | 6 | 254_303 | 68 | 222 | Domain | UMA |
Hgene | >MVB12B | chr9:129102909 | chr9:134889854 | ENST00000545391 | + | 2 | 6 | 47_193 | 68 | 222 | Domain | MABP |
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FusionGeneSequence for MVB12B_MED27 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_228aa MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVR >In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_264aa MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKL >In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_228aa MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVR >In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_264aa MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSAN QMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKL >In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_213aa MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPT TLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQA >In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_249aa MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPT TLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVT |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_684nt ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCC AACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGA TCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCG >In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_792nt ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTG AAAGTGATCGTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTT GATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATG CCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTG >In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_684nt ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCC AACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGA TCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCG >In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_792nt ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCC ACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAAC CGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAAT CAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGC ATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTG AAAGTGATCGTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTT GATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATG CCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTG >In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_639nt ATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACG TCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTA GCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACA ACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCC AATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCC CTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCC CCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGC >In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_747nt ATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACG TCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGACAGGCTATGACGTATTGCAGTACCATGCAGGACTA GCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACA ACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCC AATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATCGTCGTCATGCGGAGCCTGTTCATTGATCGAACAATA GTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACA GACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTAC ATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_1196nt CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAA GTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATG ACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGG GATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCCCACCCAGCACCTTCCCA GACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTCATAAAGCAGCGCCATGT GTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGACTGAAGGCAAAGAAGAC CTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTGTCGTCTCCGCGAGCTGT TACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGGTAACTTATTTTTATAAG >In-frame_MVB12B_ENST00000545391_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_1304nt CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATC GTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGG TCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTC GTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGC CTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACC CCACCCAGCACCTTCCCAGACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTT CATAAAGCAGCGCCATGTGTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGG ACTGAAGGCAAAGAAGACCTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCT GTCGTCTCCGCGAGCTGTTACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTG >In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_1196nt CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAA GTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATG ACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGG GATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCCCACCCAGCACCTTCCCA GACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTCATAAAGCAGCGCCATGT GTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGACTGAAGGCAAAGAAGAC CTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTGTCGTCTCCGCGAGCTGT TACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGGTAACTTATTTTTATAAG >In-frame_MVB12B_ENST00000361171_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_1304nt CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG ACAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGA GTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGG ATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATC GTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGG TCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTC GTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGC CTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACC CCACCCAGCACCTTCCCAGACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTT CATAAAGCAGCGCCATGTGTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGG ACTGAAGGCAAAGAAGACCTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCT GTCGTCTCCGCGAGCTGTTACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTG >In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000357028_chr9_134889854_-_1195nt AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA CAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAG TATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGA TGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGCTTGATATATGGTCCAAATCCAACTATCAAG TATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATGA CCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGG ATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCCCACCCAGCACCTTCCCAG ACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTCATAAAGCAGCGCCATGTG TGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGACTGAAGGCAAAGAAGACC TTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTGTCGTCTCCGCGAGCTGTT ACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGGTAACTTATTTTTATAAGC >In-frame_MVB12B_ENST00000436593_chr9_129102909_+_MED27_ENST00000292035_chr9_134889854_-_1303nt AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA CAGGCTATGACGTATTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAG TATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGA TGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATCG TCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGGT CCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCG TGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCC TTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCC CACCCAGCACCTTCCCAGACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTC ATAAAGCAGCGCCATGTGTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGA CTGAAGGCAAAGAAGACCTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTG TCGTCTCCGCGAGCTGTTACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGG |
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FusionGenePPI for MVB12B_MED27 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MVB12B | TSG101, VPS37A, MVB12A, LNX1, METTL15, ITM2C, FEM1B, PLCG1, SLC25A41, VPS28 | MED27 | MED10, MED9, MED29, MED19, MED28, MED26, MED30, MED22, MED1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, MED14, MED4, FBXW7, EPAS1, POLR2C, ARFGAP1, AFP, RBPJ, SOX5, CDK8, CDK19, ESR1, MED7, CCNC, MED16, MED17, MED11, MED13, MED13L, MED15, MED20, MED24, MED6, MED8, MED23, MED21 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MVB12B_MED27 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MVB12B_MED27 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |