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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22885

FusionGeneSummary for MUC4_TNK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MUC4_TNK2
Fusion gene ID: 22885
HgeneTgene
Gene symbol

MUC4

TNK2

Gene ID

4585

10188

Gene namemucin 4, cell surface associatedtyrosine kinase non receptor 2
SynonymsASGP|HSA276359|MUC-4ACK|ACK-1|ACK1|p21cdc42Hs
Cytomap

3q29

3q29

Type of geneprotein-codingprotein-coding
Descriptionmucin-4ascites sialoglycoproteinmucin 4, tracheobronchialpancreatic adenocarcinoma mucintestis mucintracheobronchial mucinactivated CDC42 kinase 1activated Cdc42-associated kinase 1activated p21cdc42Hs kinasetyrosine kinase non-receptor protein 2
Modification date2018052220180523
UniProtAcc

Q99102

Q07912

Ensembl transtripts involved in fusion geneENST00000346145, ENST00000349607, 
ENST00000463781, ENST00000475231, 
ENST00000478685, 
ENST00000381916, 
ENST00000333602, ENST00000428187, 
ENST00000392400, ENST00000316664, 
ENST00000468819, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 3 X 3=27
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MUC4 [Title/Abstract] AND TNK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNK2

GO:0016310

phosphorylation

20333297|20979614

TgeneTNK2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10587647

TgeneTNK2

GO:2000369

regulation of clathrin-dependent endocytosis

18262180


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-C5-A8XK-01AMUC4chr3

195495893

-TNK2chr3

195610180

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000346145ENST00000381916MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000346145ENST00000333602MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000346145ENST00000428187MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000346145ENST00000392400MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000346145ENST00000316664MUC4chr3

195495893

-TNK2chr3

195610180

-
5CDS-5UTRENST00000346145ENST00000468819MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000349607ENST00000381916MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000349607ENST00000333602MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000349607ENST00000428187MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000349607ENST00000392400MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000349607ENST00000316664MUC4chr3

195495893

-TNK2chr3

195610180

-
5CDS-5UTRENST00000349607ENST00000468819MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000463781ENST00000381916MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000463781ENST00000333602MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000463781ENST00000428187MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000463781ENST00000392400MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000463781ENST00000316664MUC4chr3

195495893

-TNK2chr3

195610180

-
5CDS-5UTRENST00000463781ENST00000468819MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000475231ENST00000381916MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000475231ENST00000333602MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000475231ENST00000428187MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000475231ENST00000392400MUC4chr3

195495893

-TNK2chr3

195610180

-
Frame-shitENST00000475231ENST00000316664MUC4chr3

195495893

-TNK2chr3

195610180

-
5CDS-5UTRENST00000475231ENST00000468819MUC4chr3

195495893

-TNK2chr3

195610180

-
intron-3CDSENST00000478685ENST00000381916MUC4chr3

195495893

-TNK2chr3

195610180

-
intron-3CDSENST00000478685ENST00000333602MUC4chr3

195495893

-TNK2chr3

195610180

-
intron-3CDSENST00000478685ENST00000428187MUC4chr3

195495893

-TNK2chr3

195610180

-
intron-3CDSENST00000478685ENST00000392400MUC4chr3

195495893

-TNK2chr3

195610180

-
intron-3CDSENST00000478685ENST00000316664MUC4chr3

195495893

-TNK2chr3

195610180

-
intron-5UTRENST00000478685ENST00000468819MUC4chr3

195495893

-TNK2chr3

195610180

-

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FusionProtFeatures for MUC4_TNK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MUC4

Q99102

TNK2

Q07912

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration,cell survival, cell growth and proliferation. Transducesextracellular signals to cytosolic and nuclear effectors.Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated intrafficking and clathrin-mediated endocytosis through binding toepidermal growth factor receptor (EGFR) and clathrin. Binds toboth poly- and mono-ubiquitin and regulates ligand-induceddegradation of EGFR, thereby contributing to the accumulation ofEGFR at the limiting membrane of early endosomes. Downstreameffector of CDC42 which mediates CDC42-dependent cell migrationvia phosphorylation of BCAR1. May be involved both in adultsynaptic function and plasticity and in brain development.Activates AKT1 by phosphorylating it on 'Tyr-176'. PhosphorylatesAR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment toandrogen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as aguanine nucleotide exchange factor (GEF) toward Rho familyproteins. Contributes to the control of AXL receptor levels.Confers metastatic properties on cancer cells and promotes tumorgrowth by negatively regulating tumor suppressor such as WWOX andpositively regulating pro-survival factors such as AKT1 and AR.Phosphorylates WASP (PubMed:20110370).{ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436,ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963,ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317,ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854,ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370,ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MUC4_TNK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MUC4_TNK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MUC4TNK2HSH2D, GRB2, CDC42, CLTC, FYN, MCF2, EGFR, NEDD4, CLTA, AMPH, BIN1, FABP4, NEDD4L, SMURF1, WWP2, HECW1, BAG3, MAGI3, WWOX, SRC, KAT8, KAT5, AXL, PDGFRB, LTK, ALK, EEA1, BCAR1, HSP90AA1, MERTK, AR, NPHP1, WAS, SNX9, ZBTB16, EP300, TP73, YES1, HCK, LYN, NCK1, CTTN, TNK2, KCNA5, SIAH1, SIAH2, ATG16L1, SQSTM1, NBR1, TP53, NTRK1, NTRK2, NTRK3, TRIM50, AQP1, GALT, SH2D1A, NEK6, KRTAP10-3, NOTCH2NL, NCK2, KDM3A, AKT1, PDK1, SOCS4, GAK, GTSE1, FGFR1, HSP90AB3P, ISG15, CDC37, LCP2, STAT1, HSP90AB1, HSPA9, SLC25A5, CSK, HSP90AB2P, HAX1, CRKL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MUC4_TNK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MUC4_TNK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMUC4C0000786Spontaneous abortion1CTD_human
HgeneMUC4C0007134Renal Cell Carcinoma1CTD_human
HgeneMUC4C0033578Prostatic Neoplasms1CTD_human
TgeneTNK2C0023903Liver neoplasms1CTD_human
TgeneTNK2C0032927Precancerous Conditions1CTD_human