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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22867

FusionGeneSummary for MUC16_ZC3H4

check button Fusion gene summary
Fusion gene informationFusion gene name: MUC16_ZC3H4
Fusion gene ID: 22867
HgeneTgene
Gene symbol

MUC16

ZC3H4

Gene ID

94025

23211

Gene namemucin 16, cell surface associatedzinc finger CCCH-type containing 4
SynonymsCA125C19orf7
Cytomap

19p13.2

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionmucin-16CA125 ovarian cancer antigenovarian cancer-related tumor marker CA125ovarian carcinoma antigen CA125zinc finger CCCH domain-containing protein 4
Modification date2018051920180523
UniProtAcc

Q9UPT8

Ensembl transtripts involved in fusion geneENST00000397910, ENST00000380951, 
ENST00000596956, 
ENST00000253048, 
ENST00000594019, 
Fusion gene scores* DoF score10 X 10 X 2=2004 X 6 X 4=96
# samples 116
** MAII scorelog2(11/200*10)=-0.862496476250065
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MUC16 [Title/Abstract] AND ZC3H4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-23-1032-01AMUC16chr19

9072451

-ZC3H4chr19

47568759

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000397910ENST00000253048MUC16chr19

9072451

-ZC3H4chr19

47568759

-
intron-5UTRENST00000397910ENST00000594019MUC16chr19

9072451

-ZC3H4chr19

47568759

-
intron-3UTRENST00000380951ENST00000253048MUC16chr19

9072451

-ZC3H4chr19

47568759

-
intron-5UTRENST00000380951ENST00000594019MUC16chr19

9072451

-ZC3H4chr19

47568759

-
intron-3UTRENST00000596956ENST00000253048MUC16chr19

9072451

-ZC3H4chr19

47568759

-
intron-5UTRENST00000596956ENST00000594019MUC16chr19

9072451

-ZC3H4chr19

47568759

-

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FusionProtFeatures for MUC16_ZC3H4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MUC16

ZC3H4

Q9UPT8

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MUC16_ZC3H4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MUC16_ZC3H4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MUC16LGALS1, IGBP1, UBC, RAD21, CEP170P1, MCM2, NANOG, POU5F1, EGFR, TRIM25ZC3H4MRPL45, USP28, DBN1, WIZ, SDHA, FLNB, SHMT1, PSMA2, MARC1, DYNC1H1, PAF1, SLC25A10, OBSL1, RNF2, BMI1, RSPH9, ZFP41, NTRK1, CDC42, RC3H1, EGFR, CAPN13, JMJD6, HTRA4, PDGFB, MRPS11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MUC16_ZC3H4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MUC16_ZC3H4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMUC16C0033687Proteinuria1CTD_human
HgeneMUC16C0919267ovarian neoplasm1CTD_human