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Fusion gene ID: 22862 |
FusionGeneSummary for MUC16_RARA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MUC16_RARA | Fusion gene ID: 22862 | Hgene | Tgene | Gene symbol | MUC16 | RARA | Gene ID | 94025 | 5914 |
| Gene name | mucin 16, cell surface associated | retinoic acid receptor alpha | |
| Synonyms | CA125 | NR1B1|RAR | |
| Cytomap | 19p13.2 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mucin-16CA125 ovarian cancer antigenovarian cancer-related tumor marker CA125ovarian carcinoma antigen CA125 | retinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P10276 | ||
| Ensembl transtripts involved in fusion gene | ENST00000397910, ENST00000380951, ENST00000596956, | ENST00000254066, ENST00000394089, ENST00000425707, ENST00000394086, ENST00000394081, ENST00000420042, | |
| Fusion gene scores | * DoF score | 10 X 10 X 2=200 | 18 X 16 X 10=2880 |
| # samples | 11 | 42 | |
| ** MAII score | log2(11/200*10)=-0.862496476250065 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(42/2880*10)=-2.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MUC16 [Title/Abstract] AND RARA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RARA | GO:0007165 | signal transduction | 2825025 |
| Tgene | RARA | GO:0030853 | negative regulation of granulocyte differentiation | 19917671 |
| Tgene | RARA | GO:0032689 | negative regulation of interferon-gamma production | 18416830 |
| Tgene | RARA | GO:0032720 | negative regulation of tumor necrosis factor production | 18416830 |
| Tgene | RARA | GO:0032736 | positive regulation of interleukin-13 production | 18416830 |
| Tgene | RARA | GO:0032753 | positive regulation of interleukin-4 production | 18416830 |
| Tgene | RARA | GO:0032754 | positive regulation of interleukin-5 production | 18416830 |
| Tgene | RARA | GO:0045630 | positive regulation of T-helper 2 cell differentiation | 18416830 |
| Tgene | RARA | GO:0045892 | negative regulation of transcription, DNA-templated | 20080953 |
| Tgene | RARA | GO:0045893 | positive regulation of transcription, DNA-templated | 18845237|19850744|20080953 |
| Tgene | RARA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19850744 |
| Tgene | RARA | GO:0071300 | cellular response to retinoic acid | 19917671 |
| Tgene | RARA | GO:0071391 | cellular response to estrogen stimulus | 20080953 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-29-2428-01A | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000397910 | ENST00000254066 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| 5CDS-5UTR | ENST00000397910 | ENST00000394089 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| 5CDS-5UTR | ENST00000397910 | ENST00000425707 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| 5CDS-intron | ENST00000397910 | ENST00000394086 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| 5CDS-intron | ENST00000397910 | ENST00000394081 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| 5CDS-intron | ENST00000397910 | ENST00000420042 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-5UTR | ENST00000380951 | ENST00000254066 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-5UTR | ENST00000380951 | ENST00000394089 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-5UTR | ENST00000380951 | ENST00000425707 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-intron | ENST00000380951 | ENST00000394086 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-intron | ENST00000380951 | ENST00000394081 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-intron | ENST00000380951 | ENST00000420042 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-5UTR | ENST00000596956 | ENST00000254066 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-5UTR | ENST00000596956 | ENST00000394089 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-5UTR | ENST00000596956 | ENST00000425707 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-intron | ENST00000596956 | ENST00000394086 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-intron | ENST00000596956 | ENST00000394081 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
| intron-intron | ENST00000596956 | ENST00000420042 | MUC16 | chr19 | 9045564 | - | RARA | chr17 | 38487109 | + |
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FusionProtFeatures for MUC16_RARA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MUC16 | RARA |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Receptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RXR/RARheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence of ligand, the RXR-RAR heterodimers associate with amultiprotein complex containing transcription corepressors thatinduce histone acetylation, chromatin condensation andtranscriptional suppression. On ligand binding, the corepressorsdissociate from the receptors and associate with the coactivatorsleading to transcriptional activation. RARA plays an essentialrole in the regulation of retinoic acid-induced germ celldevelopment during spermatogenesis. Has a role in the survival ofearly spermatocytes at the beginning prophase of meiosis. InSertoli cells, may promote the survival and development of earlymeiotic prophase spermatocytes. In concert with RARG, required forskeletal growth, matrix homeostasis and growth plate function (Bysimilarity). {ECO:0000250|UniProtKB:P11416,ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19850744,ECO:0000269|PubMed:20215566}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MUC16_RARA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MUC16_RARA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MUC16 | LGALS1, IGBP1, UBC, RAD21, CEP170P1, MCM2, NANOG, POU5F1, EGFR, TRIM25 | RARA | NRBF2, ZBTB16, MECR, RXRG, RXRB, NCOA6, GADD45G, GADD45A, NRIP1, KAT2B, HDAC3, HDAC4, TDG, PML, TRIP4, KDM5A, RXRA, POU2F1, NCOR2, NR0B2, BAG1, TADA3, NCOR1, NKX2-1, TRIM24, IRX4, SP1, NPAS2, CLOCK, ARNTL, NR2E3, CCND3, NCOA2, SRC, AJUBA, LIMD1, WTIP, SKI, HR, PIN1, SUV39H1, PSMC5, EP300, PARP1, MED6, TOP2B, SAP130, HNRNPU, RFC4, NPM1, MRTO4, SNRNP40, MED1, NCOA1, HMGA1, RUVBL1, RUNX1, SIAH1, RARA, HDAC2, NCOA3, CREBBP, LRIF1, KLF5, SMARCD3, ARID1A, SPI1, PRDX6, NR1H2, ITGB1BP2, MED25, MAPK6, FOXO1, MAPK1, TRIM32, PHF8, TNIP1, HACE1, SQSTM1, UBQLN1, ARID5A, UBE3A, PRAM1, FAS, PRAME, TBL1XR1, SUZ12, EZH2, USP7, TMEM54, MMS19, AKT1, FN1, WWOX, E2F1, MBD3, MTA2, CBX5, CEBPA, HDAC1, NSD1, TEKT4, SNW1, SIRT1, ACTN4, SRF, MDM2, ZNF131, RARG, RARB, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MUC16_RARA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | RARA | P10276 | DB00210 | Adapalene | Retinoic acid receptor alpha | small molecule | approved |
| Tgene | RARA | P10276 | DB00459 | Acitretin | Retinoic acid receptor alpha | small molecule | approved |
| Tgene | RARA | P10276 | DB00982 | Isotretinoin | Retinoic acid receptor alpha | small molecule | approved |
| Tgene | RARA | P10276 | DB00523 | Alitretinoin | Retinoic acid receptor alpha | small molecule | approved|investigational |
| Tgene | RARA | P10276 | DB00799 | Tazarotene | Retinoic acid receptor alpha | small molecule | approved|investigational |
| Tgene | RARA | P10276 | DB00755 | Tretinoin | Retinoic acid receptor alpha | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for MUC16_RARA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MUC16 | C0033687 | Proteinuria | 1 | CTD_human |
| Hgene | MUC16 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | RARA | C0023487 | Acute Promyelocytic Leukemia | 22 | CTD_human;HPO;ORPHANET |
| Tgene | RARA | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | RARA | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | RARA | C0010701 | Phyllodes Tumor | 1 | CTD_human |
| Tgene | RARA | C0085183 | Neoplasms, Second Primary | 1 | CTD_human |
| Tgene | RARA | C0149940 | Sciatic Neuropathy | 1 | CTD_human |
| Tgene | RARA | C0206650 | Fibroadenoma | 1 | CTD_human |
| Tgene | RARA | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | RARA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | RARA | C2239176 | Liver carcinoma | 1 | CTD_human |
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