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Fusion gene ID: 22850 |
FusionGeneSummary for MTUS2_PTPN14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTUS2_PTPN14 | Fusion gene ID: 22850 | Hgene | Tgene | Gene symbol | MTUS2 | PTPN14 | Gene ID | 23281 | 5784 |
| Gene name | microtubule associated scaffold protein 2 | protein tyrosine phosphatase, non-receptor type 14 | |
| Synonyms | CAZIP|ICIS|KIAA0774|TIP150 | CATLPH|PEZ|PTP36 | |
| Cytomap | 13q12.3 | 1q32.3-q41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated tumor suppressor candidate 2+TIP of 150 kDacardiac zipper proteinmicrotubule associated tumor suppressor candidate 2microtubule plus-end tracking protein TIP150tracking protein of 150 kDa | tyrosine-protein phosphatase non-receptor type 14cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase pez | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q5JR59 | Q15678 | |
| Ensembl transtripts involved in fusion gene | ENST00000431530, ENST00000380808, ENST00000542829, ENST00000400542, | ENST00000366956, ENST00000543945, ENST00000491277, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 5 X 6 X 3=90 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MTUS2 [Title/Abstract] AND PTPN14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPN14 | GO:0046825 | regulation of protein export from nucleus | 22948661 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-F4-6459-01A | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000431530 | ENST00000366956 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-3CDS | ENST00000431530 | ENST00000543945 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-intron | ENST00000431530 | ENST00000491277 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-3CDS | ENST00000380808 | ENST00000366956 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-3CDS | ENST00000380808 | ENST00000543945 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-intron | ENST00000380808 | ENST00000491277 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-3CDS | ENST00000542829 | ENST00000366956 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-3CDS | ENST00000542829 | ENST00000543945 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-intron | ENST00000542829 | ENST00000491277 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-3CDS | ENST00000400542 | ENST00000366956 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-3CDS | ENST00000400542 | ENST00000543945 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
| intron-intron | ENST00000400542 | ENST00000491277 | MTUS2 | chr13 | 29394748 | + | PTPN14 | chr1 | 214576296 | - |
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FusionProtFeatures for MTUS2_PTPN14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTUS2 | PTPN14 |
| Binds microtubules. Together with MAPRE1 may target themicrotubule depolymerase KIF2C to the plus-end of microtubules.May regulate the dynamics of microtubules at their growing distaltip. {ECO:0000269|PubMed:19543227}. | Protein tyrosine phosphatase which may play a role inthe regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulatesTGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation atadhesion junctions. Acts as a negative regulator of the oncogenicproperty of YAP, a downstream target of the hippo pathway, in acell density-dependent manner. May function as a tumor suppressor.{ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048,ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270,ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271,ECO:0000269|PubMed:22948661}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MTUS2_PTPN14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MTUS2_PTPN14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTUS2 | RIBC2, ZFP64, PLK4, ZNF655, C1orf216, KAT5, ITSN1, PSMA1, ARNT2, GTF2I, IQCE, KIF1A, NUBPL, AES, SLC25A6, AQP1, BMP7, BYSL, CRY2, CTSZ, DOCK2, DTNB, HCK, HSF2, ITGB5, LMO2, MAGEA8, MFAP1, ODF1, CDK18, PIN1, PKP2, PRKAA1, RAB3IL1, RGS2, RPA1, RPL9, CXCL11, SDCBP, SMARCE1, SNAI1, SNRPA, SNRPB2, SPG7, TAF13, ZNF3, ZNF20, ZNF136, ZSCAN26, ZNF224, ZNF232, NELFE, STK16, SCEL, CDK5R1, USP2, MTMR6, CREB5, PDE4DIP, ZSCAN12, HDAC4, DLGAP5, FCHSD2, SLC23A1, COG2, SNW1, TXN2, POLDIP2, PRPF31, ZNF337, AFF4, NDOR1, DCTN4, CDKL3, WAC, PPHLN1, ZNF581, C21orf58, CCHCR1, C1orf109, FBXO34, WDYHV1, FAM90A1, C14orf105, SETD5, C19orf66, LIMS2, ZNF415, PLSCR4, CBX8, ZNF490, ZNF624, TSHZ3, CCDC146, MARK4, ZNF410, CXCL16, ZNF250, DMRT3, SH2D4A, GAL3ST2, ROBO3, CERK, AEN, C20orf195, ZFYVE21, ZNF426, LENG1, CDC73, ZNF329, ZC2HC1C, FBXL18, ZFP2, THAP7, NDEL1, SLIRP, FAM161A, POLDIP3, LNX1, ZNF607, ZNF587, GTPBP10, ZNF439, CEP95, ZNF670, TP53RK, RHPN1, PTPMT1, HAUS1, C8orf34, CATSPER1, LRR1, ZNF440, SNHG11, ZNF572, SELM, CWF19L2, SPATA8, ZNF785, ZNF417, ZNF599, SYT6, DCDC2B, CCDC17, ALS2CR11, ZMAT2, LOC153684, SH3RF2, CCDC60, CCDC116, CDC20B, NUDT10, PPP1R18, ZFC3H1, FAM13C, ZBTB38, TSGA10IP, GOLGA2P11, ZNF844, FAM71E2, RTP5, LINC00636, CEP57L1, TRIM42, CATIP, LYSMD1, FAM74A4, MAPRE1, MTUS2, KIF2C, FHL3, TULP2, ZNF557, FAM110A, TFG, MTUS1, CCDC6, ATP11C, MYADM, TMEM63B, ATP6V0C, ATP6V0A2, DCAF10, MLLT4, RABL6, ATP6V0A1, MTDH, CD109, MACF1, DDX46, CCP110, SCAF8, EIF5B, FRA10AC1, FYN, ULBP2, PAG1, AP1B1, CAST, PAK4 | PTPN14 | CTNNB1, CTNNA1, TJP1, JUP, MYC, PTEN, AMOT, YWHAE, CUL2, YAP1, PLK1, DDB1, PPP2R1A, PPP2R2A, WWC1, YWHAZ, YWHAB, WWC2, UBC, COPS4, STK3, LRR1, WWP1, WWP2, CSNK1D, VHL, NPM1, LATS1, LATS2, MOB1A, MOB1B, SAV1, WWOX, PARD6B, CRLF3, PDLIM7, CTDSPL, MAGI1, RHPN1, MAGI3, STXBP4, PHF20, JPH4, ACAD11, PTPN14, ANKRD50, RMND5A, BAG3, HECW2, MAEA, WDR26, ARMC8, YWHAH, GPS1, AMMECR1L, NDEL1, ACAD8, BPIFB1, ATE1, RANBP10, CCT8L1P, YWHAG, USP9X, KIF2A, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, SRGAP2, MAST3, EIF4E2, SIPA1L1, PPM1H, LIMA1, TESK2, DCLK1, ZNF638, DENND4C, HDAC4, NF1, CBY1, SRSF12, SYDE1, INPP5E |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTUS2_PTPN14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTUS2_PTPN14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PTPN14 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
| Tgene | PTPN14 | C0027819 | Neuroblastoma | 1 | CTD_human |
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