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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22836

FusionGeneSummary for MTSS1L_SAMD9L

check button Fusion gene summary
Fusion gene informationFusion gene name: MTSS1L_SAMD9L
Fusion gene ID: 22836
HgeneTgene
Gene symbol

MTSS1L

SAMD9L

Gene ID

92154

219285

Gene nameMTSS1L, I-BAR domain containingsterile alpha motif domain containing 9 like
SynonymsABBA|ABBA-1|ABBA1ATXPC|C7orf6|DRIF2|UEF1
Cytomap

16q22.1

7q21.2

Type of geneprotein-codingprotein-coding
DescriptionMTSS1-like proteinactin-bundling with BAIAP2 homology protein 1metastasis suppressor 1-likesterile alpha motif domain-containing protein 9-likeSAM domain-containing protein 9-like
Modification date2018051920180523
UniProtAcc

Q765P7

Q8IVG5

Ensembl transtripts involved in fusion geneENST00000338779, ENST00000318238, 
ENST00000411955, ENST00000437805, 
ENST00000477816, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: MTSS1L [Title/Abstract] AND SAMD9L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTSS1L

GO:0036120

cellular response to platelet-derived growth factor stimulus

20875796

HgeneMTSS1L

GO:0090630

activation of GTPase activity

20875796


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW298142MTSS1Lchr16

70695216

+SAMD9Lchr7

92760330

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000338779ENST00000318238MTSS1Lchr16

70695216

+SAMD9Lchr7

92760330

+
intron-3UTRENST00000338779ENST00000411955MTSS1Lchr16

70695216

+SAMD9Lchr7

92760330

+
intron-intronENST00000338779ENST00000437805MTSS1Lchr16

70695216

+SAMD9Lchr7

92760330

+
intron-intronENST00000338779ENST00000477816MTSS1Lchr16

70695216

+SAMD9Lchr7

92760330

+

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FusionProtFeatures for MTSS1L_SAMD9L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTSS1L

Q765P7

SAMD9L

Q8IVG5

Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia infibroblasts, acting via RAC1 activation (PubMed:14752106). Mayfunction in actin bundling (PubMed:14752106).{ECO:0000269|PubMed:14752106}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTSS1L_SAMD9L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTSS1L_SAMD9L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTSS1L_SAMD9L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTSS1L_SAMD9L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSAMD9LC1327919Myelocerebellar Disorder1ORPHANET;UNIPROT