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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22808

FusionGeneSummary for MTMR6_CDX2

check button Fusion gene summary
Fusion gene informationFusion gene name: MTMR6_CDX2
Fusion gene ID: 22808
HgeneTgene
Gene symbol

MTMR6

CDX2

Gene ID

9107

1045

Gene namemyotubularin related protein 6caudal type homeobox 2
Synonyms-CDX-3|CDX2/AS|CDX3
Cytomap

13q12.13

13q12.2

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 6homeobox protein CDX-2caudal type homeobox transcription factor 2caudal-type homeobox protein 2homeobox protein miniCDX2
Modification date2018051920180527
UniProtAcc

Q9Y217

Q99626

Ensembl transtripts involved in fusion geneENST00000540661, ENST00000381801, 
ENST00000482345, 
ENST00000381020, 
ENST00000548877, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: MTMR6 [Title/Abstract] AND CDX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTMR6

GO:0046856

phosphatidylinositol dephosphorylation

22647598

TgeneCDX2

GO:0000122

negative regulation of transcription by RNA polymerase II

15677472


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-28-5207-01AMTMR6chr13

25841917

-CDX2chr13

28537506

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000540661ENST00000381020MTMR6chr13

25841917

-CDX2chr13

28537506

-
5CDS-5UTRENST00000540661ENST00000548877MTMR6chr13

25841917

-CDX2chr13

28537506

-
Frame-shiftENST00000381801ENST00000381020MTMR6chr13

25841917

-CDX2chr13

28537506

-
5CDS-5UTRENST00000381801ENST00000548877MTMR6chr13

25841917

-CDX2chr13

28537506

-
intron-3CDSENST00000482345ENST00000381020MTMR6chr13

25841917

-CDX2chr13

28537506

-
intron-5UTRENST00000482345ENST00000548877MTMR6chr13

25841917

-CDX2chr13

28537506

-

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FusionProtFeatures for MTMR6_CDX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTMR6

Q9Y217

CDX2

Q99626

Phosphatase that acts on lipids with a phosphoinositolheadgroup. Acts as a negative regulator of KCNN4/KCa3.1 channelactivity in CD4+ T-cells possibly by decreasing intracellularlevels of phosphatidylinositol 3 phosphatase. Negatively regulatesproliferation of reactivated CD4+ T-cells.{ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315}. Involved in the transcriptional regulation of multiplegenes expressed in the intestinal epithelium. Important in broadrange of functions from early differentiation to maintenance ofthe intestinal epithelial lining of both the small and largeintestine. Binds preferentially to methylated DNA(PubMed:28473536). {ECO:0000269|PubMed:28473536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTMR6_CDX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTMR6_CDX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTMR6MTMR9, ELAVL1, RARG, TRIM27, NMI, MTUS2, AMOTL2, ZWINT, KCTD17, STK25, HIP1R, CEP170, CEP19, STIL, TMEM17, MTMR6, IFI30, CARM1, SOAT1, BBS7, RPL34, MTMR7, CDA, FHIT, KCNJ5, BHMT, CTSE, LMTK2, AATK, ERBB4, ERBB3, ROR2, PTK7, MTNR1BCDX2PAX6, EP300, HNF1A, KDM5B, SMARCA2, SMARCA4, SMARCB1, SMARCD1, CDK2, FOXE1, DNMT3L, NFKB1, RELA, FBXW7, GSK3B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTMR6_CDX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTMR6_CDX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource