FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22806

FusionGeneSummary for MTMR3_ZNRF3

check button Fusion gene summary
Fusion gene informationFusion gene name: MTMR3_ZNRF3
Fusion gene ID: 22806
HgeneTgene
Gene symbol

MTMR3

ZNRF3

Gene ID

8897

84133

Gene namemyotubularin related protein 3zinc and ring finger 3
SynonymsFYVE-DSP1|ZFYVE10BK747E2.3|RNF203
Cytomap

22q12.2

22q12.1

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 3FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphataseFYVE domain-containing dual specificity protein phosphatase 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phoE3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3
Modification date2018051920180523
UniProtAcc

Q13615

Q9ULT6

Ensembl transtripts involved in fusion geneENST00000401950, ENST00000333027, 
ENST00000323630, ENST00000351488, 
ENST00000406629, ENST00000415511, 
ENST00000544604, ENST00000332811, 
ENST00000402174, ENST00000406323, 
Fusion gene scores* DoF score12 X 5 X 9=5407 X 6 X 6=252
# samples 159
** MAII scorelog2(15/540*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTMR3 [Title/Abstract] AND ZNRF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTMR3

GO:0006470

protein dephosphorylation

10733931

HgeneMTMR3

GO:0046856

phosphatidylinositol dephosphorylation

10900271|11676921

HgeneMTMR3

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938

HgeneMTMR3

GO:1904562

phosphatidylinositol 5-phosphate metabolic process

11676921

TgeneZNRF3

GO:0016567

protein ubiquitination

22575959


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A118-01AMTMR3chr22

30279348

+ZNRF3chr22

29383064

+
TCGALDOVTCGA-36-1575-01AMTMR3chr22

30279348

+ZNRF3chr22

29383064

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000401950ENST00000544604MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000401950ENST00000332811MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000401950ENST00000402174MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000401950ENST00000406323MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000333027ENST00000544604MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000333027ENST00000332811MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000333027ENST00000402174MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000333027ENST00000406323MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000323630ENST00000544604MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000323630ENST00000332811MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000323630ENST00000402174MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000323630ENST00000406323MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000351488ENST00000544604MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000351488ENST00000332811MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000351488ENST00000402174MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
5UTR-3CDSENST00000351488ENST00000406323MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
intron-3CDSENST00000406629ENST00000544604MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
intron-3CDSENST00000406629ENST00000332811MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
intron-3CDSENST00000406629ENST00000402174MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
intron-3CDSENST00000406629ENST00000406323MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
3UTR-3CDSENST00000415511ENST00000544604MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
3UTR-3CDSENST00000415511ENST00000332811MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
3UTR-3CDSENST00000415511ENST00000402174MTMR3chr22

30279348

+ZNRF3chr22

29383064

+
3UTR-3CDSENST00000415511ENST00000406323MTMR3chr22

30279348

+ZNRF3chr22

29383064

+

Top

FusionProtFeatures for MTMR3_ZNRF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTMR3

Q13615

ZNRF3

Q9ULT6

Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol3-phosphate and phosphatidylinositol 3,5-bisphosphate. May alsodephosphorylate proteins phosphorylated on Ser, Thr, and Tyrresidues (PubMed:10733931). {ECO:0000269|PubMed:10733931,ECO:0000269|PubMed:11676921}. E3 ubiquitin-protein ligase that acts as a negativeregulator of the Wnt signaling pathway by mediating theubiquitination and subsequent degradation of Wnt receptor complexcomponents Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in theintestinal stem cell zone by inhibiting the Wnt signaling pathway,thereby resticting the size of the intestinal stem cell zone.{ECO:0000269|PubMed:22575959}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MTMR3_ZNRF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MTMR3_ZNRF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTMR3CUL3, HIVEP1, ANKRD28, PNO1, WRAP73, AURKA, HERC2, ATM, THOC2, MTOR, MTMR4, MLST8, RPTOR, PLK1, EYA3, MTMR3, ORC4, HEATR1, MAPK1IP1L, IPO5, SSBP1, NUP205, MED18, ALOX5, HDAC11, TULP3, DNAJC10, FGFR2, TRIM25ZNRF3UBE2N, FZD4, RSPO1, LGR4, LRP6, GFI1B, DVL2, HSPB1, RSPO2, RSPO3, LGR5, FZD7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MTMR3_ZNRF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MTMR3_ZNRF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZNRF3C0030297Pancreatic Neoplasm2CTD_human
TgeneZNRF3C0206686Adrenocortical carcinoma1CTD_human