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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22786

FusionGeneSummary for MTMR1_FATE1

check button Fusion gene summary
Fusion gene informationFusion gene name: MTMR1_FATE1
Fusion gene ID: 22786
HgeneTgene
Gene symbol

MTMR1

FATE1

Gene ID

8776

89885

Gene namemyotubularin related protein 1fetal and adult testis expressed 1
Synonyms-CT43|FATE
Cytomap

Xq28

Xq28

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phosphatasefetal and adult testis-expressed transcript proteinBJ-HCC-2 antigencancer/testis antigen 43tumor antigen BJ-HCC-2
Modification date2018051920180523
UniProtAcc

Q13613

Q969F0

Ensembl transtripts involved in fusion geneENST00000541925, ENST00000542156, 
ENST00000370390, ENST00000451863, 
ENST00000544228, ENST00000445323, 
ENST00000538506, 
ENST00000370350, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: MTMR1 [Title/Abstract] AND FATE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTMR1

GO:0046856

phosphatidylinositol dephosphorylation

11733541|27018598

HgeneMTMR1

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938

TgeneFATE1

GO:0043066

negative regulation of apoptotic process

12865919|26567849

TgeneFATE1

GO:0051562

negative regulation of mitochondrial calcium ion concentration

12865919


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A08G-01AMTMR1chrX

149887172

+FATE1chrX

150889867

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000541925ENST00000370350MTMR1chrX

149887172

+FATE1chrX

150889867

+
Frame-shitENST00000542156ENST00000370350MTMR1chrX

149887172

+FATE1chrX

150889867

+
Frame-shitENST00000370390ENST00000370350MTMR1chrX

149887172

+FATE1chrX

150889867

+
Frame-shitENST00000451863ENST00000370350MTMR1chrX

149887172

+FATE1chrX

150889867

+
Frame-shitENST00000544228ENST00000370350MTMR1chrX

149887172

+FATE1chrX

150889867

+
Frame-shitENST00000445323ENST00000370350MTMR1chrX

149887172

+FATE1chrX

150889867

+
5UTR-3CDSENST00000538506ENST00000370350MTMR1chrX

149887172

+FATE1chrX

150889867

+

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FusionProtFeatures for MTMR1_FATE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTMR1

Q13613

FATE1

Q969F0

Lipid phosphatase that has high specificity forphosphatidylinositol 3-phosphate and has no activity withphosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate(PubMed:11733541, PubMed:27018598). Activity withphosphatidylinositol (3,5)-bisphosphate is controversial; it hasbeen shown by PubMed:27018598, while PubMed:11733541 find noactivity with this substrate. {ECO:0000269|PubMed:11733541,ECO:0000269|PubMed:27018598}. Involved in the regulation of endoplasmic reticulum(ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondriapossibly implicating it in the regulation of apoptosis(PubMed:27402544). May collaborate with RNF183 to restrain BIKprotein levels thus regulating apoptotic signaling(PubMed:26567849). {ECO:0000269|PubMed:27402544,ECO:0000305|PubMed:26567849}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTMR1_FATE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTMR1_FATE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTMR1AURKB, CEP250, TUBGCP3, EFNB2, SKAP1, TRIM10, PSMC2, FBXW11, FOS, SLC4A1AP, MTMR2, SBF1, SBF2, GMNN, RPGR, LIPC, RAB6B, HAVCR2, PIP4K2A, SELE, LRRC4C, TMEM52B, ERBB3, ROR2, PTK7FATE1EMD, RNF183, USHBP1, TRAF2, TBP, AQP9, BCL2L2, BIK, BNIP2, BNIP3, BNIP3L, CD79A, CSF2RA, GPR25, MR1, KCNS2, LNPEP, PIN4, PRRG2, SLC7A1, TM4SF4, BSND, SEC22C, SYNGR1, CD302, BTN2A2, SEC23B, USP20, SEC22A, MARCH2, TIMMDC1, INPP5K, NDUFB11, MARCH5, RPRM, AGTRAP, SYNDIG1, TRAF3IP3, SLC38A1, CCDC70, YIPF4, DCTN5, SNAP47, SYNPR, NRSN1, NRG4, CCDC155, TMEM74, SYNE4, SMIM14, OCLN, YIPF2, TMEM11, SYNGR2, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTMR1_FATE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTMR1_FATE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFATE1C2239176Liver carcinoma1CTD_human