|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22760 |
FusionGeneSummary for MTHFD1L_THEMIS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTHFD1L_THEMIS | Fusion gene ID: 22760 | Hgene | Tgene | Gene symbol | MTHFD1L | THEMIS | Gene ID | 25902 | 387357 |
| Gene name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | thymocyte selection associated | |
| Synonyms | FTHFSDC1|MTC1THFS|dJ292B18.2 | C6orf190|C6orf207|GASP|SPOT|TSEPA | |
| Cytomap | 6q25.1 | 6q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | monofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1 | protein THEMISGRB2-associated proteinsignaling phosphoprotein specific for T cellsthymocyte selection pathway associatedthymocyte-expressed molecule involved in selection | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6UB35 | Q8N1K5 | |
| Ensembl transtripts involved in fusion gene | ENST00000367321, ENST00000367307, ENST00000478643, | ENST00000368250, ENST00000368248, ENST00000543064, ENST00000537166, | |
| Fusion gene scores | * DoF score | 6 X 8 X 4=192 | 3 X 3 X 3=27 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/192*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MTHFD1L [Title/Abstract] AND THEMIS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTHFD1L | GO:0006760 | folic acid-containing compound metabolic process | 12937168 |
| Hgene | MTHFD1L | GO:0015942 | formate metabolic process | 16171773 |
| Hgene | MTHFD1L | GO:0046653 | tetrahydrofolate metabolic process | 12937168 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A13Z-01A | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| TCGA | LD | BRCA | TCGA-E9-A248-01A | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000367321 | ENST00000368250 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| In-frame | ENST00000367321 | ENST00000368248 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| In-frame | ENST00000367321 | ENST00000543064 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| In-frame | ENST00000367321 | ENST00000537166 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000367307 | ENST00000368250 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000367307 | ENST00000368248 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000367307 | ENST00000543064 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000367307 | ENST00000537166 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000478643 | ENST00000368250 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000478643 | ENST00000368248 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000478643 | ENST00000543064 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| intron-3CDS | ENST00000478643 | ENST00000537166 | MTHFD1L | chr6 | 151355736 | + | THEMIS | chr6 | 128040968 | - |
| 5CDS-5UTR | ENST00000367321 | ENST00000368250 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| 5CDS-5UTR | ENST00000367321 | ENST00000368248 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| 5CDS-5UTR | ENST00000367321 | ENST00000543064 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| 5CDS-5UTR | ENST00000367321 | ENST00000537166 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| 5CDS-5UTR | ENST00000367307 | ENST00000368250 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| 5CDS-5UTR | ENST00000367307 | ENST00000368248 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| 5CDS-5UTR | ENST00000367307 | ENST00000543064 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| 5CDS-5UTR | ENST00000367307 | ENST00000537166 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| intron-5UTR | ENST00000478643 | ENST00000368250 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| intron-5UTR | ENST00000478643 | ENST00000368248 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| intron-5UTR | ENST00000478643 | ENST00000543064 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
| intron-5UTR | ENST00000478643 | ENST00000537166 | MTHFD1L | chr6 | 151187185 | + | THEMIS | chr6 | 128176333 | - |
Top |
FusionProtFeatures for MTHFD1L_THEMIS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTHFD1L | THEMIS |
| May provide the missing metabolic reaction required tolink the mitochondria and the cytoplasm in the mammalian model ofone-carbon folate metabolism in embryonic an transformed cellscomplementing thus the enzymatic activities of MTHFD2.{ECO:0000250, ECO:0000269|PubMed:16171773}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367321 | + | 25 | 28 | 34_42 | 898 | 932 | Compositional bias | Note=Poly-Gly |
| Hgene | MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367321 | + | 25 | 28 | 423_430 | 898 | 932 | Nucleotide binding | ATP |
| Hgene | MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367321 | + | 25 | 28 | 31_348 | 898 | 932 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367307 | + | 1 | 8 | 34_42 | -90 | 276 | Compositional bias | Note=Poly-Gly |
| Hgene | >MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367307 | + | 1 | 8 | 423_430 | -90 | 276 | Nucleotide binding | ATP |
| Hgene | >MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367307 | + | 1 | 8 | 31_348 | -90 | 276 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase |
| Hgene | >MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367307 | + | 1 | 8 | 349_978 | -90 | 276 | Region | Note=Formyltetrahydrofolate synthetase |
| Hgene | >MTHFD1L | chr6:151355736 | chr6:128040968 | ENST00000367321 | + | 25 | 28 | 349_978 | 898 | 932 | Region | Note=Formyltetrahydrofolate synthetase |
| Tgene | THEMIS | chr6:151355736 | chr6:128040968 | ENST00000368248 | - | 3 | 6 | 1_259 | 586 | 642 | Region | Note=CABIT 1 |
| Tgene | THEMIS | chr6:151355736 | chr6:128040968 | ENST00000368248 | - | 3 | 6 | 260_518 | 586 | 642 | Region | Note=CABIT 2 |
| Tgene | THEMIS | chr6:151355736 | chr6:128040968 | ENST00000537166 | - | 3 | 6 | 1_259 | 551 | 607 | Region | Note=CABIT 1 |
| Tgene | THEMIS | chr6:151355736 | chr6:128040968 | ENST00000537166 | - | 3 | 6 | 260_518 | 551 | 607 | Region | Note=CABIT 2 |
Top |
FusionGeneSequence for MTHFD1L_THEMIS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000368250_chr6_128040968_-_954aa MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQ EKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD GVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLG SPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFA CLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARL KKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLG RMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGM EKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEI DLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRH >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000368248_chr6_128040968_-_954aa MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQ EKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD GVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLG SPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFA CLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARL KKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLG RMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGM EKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEI DLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRH >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000543064_chr6_128040968_-_954aa MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQ EKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD GVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLG SPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFA CLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARL KKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLG RMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGM EKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEI DLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRH >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000537166_chr6_128040968_-_954aa MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQ EKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD GVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLG SPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFA CLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARL KKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLG RMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGM EKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEI DLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000368250_chr6_128040968_-_2862nt ATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGC GCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGC TGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAA GAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAG GAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGAT ACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGAT GGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTT CTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTC CAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGC TCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTT GGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATG GTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCA AGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATC TATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATC ACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCC TGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAG TTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAA AACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTA AAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACC ATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGG CAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGA AGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGAT GCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCT TCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATG GAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCAT GGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAAC CTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATT GACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGAC TTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGG ACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCGTCAT CACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGATGAA >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000368248_chr6_128040968_-_2862nt ATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGC GCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGC TGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAA GAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAG GAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGAT ACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGAT GGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTT CTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTC CAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGC TCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTT GGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATG GTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCA AGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATC TATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATC ACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCC TGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAG TTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAA AACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTA AAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACC ATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGG CAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGA AGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGAT GCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCT TCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATG GAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCAT GGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAAC CTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATT GACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGAC TTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGG ACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCGTCAT CACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGATGAA >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000543064_chr6_128040968_-_2862nt ATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGC GCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGC TGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAA GAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAG GAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGAT ACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGAT GGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTT CTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTC CAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGC TCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTT GGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATG GTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCA AGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATC TATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATC ACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCC TGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAG TTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAA AACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTA AAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACC ATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGG CAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGA AGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGAT GCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCT TCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATG GAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCAT GGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAAC CTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATT GACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGAC TTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGG ACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCGTCAT CACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGATGAA >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000537166_chr6_128040968_-_2862nt ATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGC GCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGC TGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAA GAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAG GAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGAT ACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGAT GGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTT CTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTC CAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGC TCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTT GGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATG GTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCA AGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATC TATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATC ACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCC TGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAG TTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAA AACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTA AAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACC ATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGG CAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGA AGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGAT GCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCT TCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATG GAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCAT GGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAAC CTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATT GACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGAC TTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGG ACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCGTCAT CACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGATGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000368250_chr6_128040968_-_5049nt TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA TAAACTTCATGCTCACCTATTGGAGATTTGGGAAGGTTGAAAATAAACTTCCTAATTTTTATTTGTATGTGTTCTCTTCTATGTTTAACT CTAGAATAACTATCTTCCTGTAACGATTAAGTTAAAATATTCTTTAACTAGAATTGAAATAAATTGTTCACTAAGGAGGGGGCTGCTTGT >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000368248_chr6_128040968_-_4927nt TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000543064_chr6_128040968_-_4927nt TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA >In-frame_MTHFD1L_ENST00000367321_chr6_151355736_+_THEMIS_ENST00000537166_chr6_128040968_-_4927nt TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA |
Top |
FusionGenePPI for MTHFD1L_THEMIS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTHFD1L | CASP4, MAGED1, WRAP73, HGS, USP50, SIRT7, CUL3, COPS5, ADRB2, HECW2, ASB12, BPHL, CNN1, CNN3, ISOC1, TAGLN2, PAPOLA, PAPOLB, XPNPEP1, NTRK1, CEP152, NPM1, LRPPRC, NFATC1, MTMR7, CYLD | THEMIS | PRMT6, PTPN11, GRB2, POTEF |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MTHFD1L_THEMIS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MTHFD1L_THEMIS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | THEMIS | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | THEMIS | C0007570 | Celiac Disease | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|