	FusionGeneSummary
	FusionProtFeature
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	FusionGenePPI
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Fusion gene ID: 22750

FusionGeneSummary for MTFR1L_MTFR1L

Fusion gene summary

Fusion gene information	Fusion gene name: MTFR1L_MTFR1L
	Fusion gene ID: 22750
		Hgene	Tgene
	Gene symbol	MTFR1L	MTFR1L
	Gene ID	56181	56181
	Gene name	mitochondrial fission regulator 1 like	mitochondrial fission regulator 1 like
	Synonyms	FAM54B\|HYST1888\|MST116\|MSTP116	FAM54B\|HYST1888\|MST116\|MSTP116
	Cytomap	1p36.11	1p36.11
	Type of gene	protein-coding	protein-coding
	Description	mitochondrial fission regulator 1-likefamily with sequence similarity 54 member Bprotein FAM54B	mitochondrial fission regulator 1-likefamily with sequence similarity 54 member Bprotein FAM54B
	Modification date	20180523	20180523
	UniProtAcc	Q9H019	Q9H019
	Ensembl transtripts involved in fusion gene	ENST00000374303, ENST00000474295, ENST00000469815, ENST00000526894, ENST00000524618, ENST00000374307, ENST00000374301, ENST00000374300, ENST00000466284,	ENST00000374303, ENST00000474295, ENST00000469815, ENST00000526894, ENST00000524618, ENST00000374307, ENST00000374301, ENST00000374300, ENST00000466284,
Fusion gene scores	* DoF score	2 X 2 X 1=4	2 X 2 X 2=8
	# samples	2	2
	** MAII score	log2(2/4*10)=2.32192809488736	log2(2/8*10)=1.32192809488736
Context	PubMed: MTFR1L [Title/Abstract] AND MTFR1L [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF336776	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000374303	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374303	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374303	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374303	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374303	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374303	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374303	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374303	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374303	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000474295	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000474295	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000474295	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000474295	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000474295	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000474295	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000474295	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000474295	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000474295	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-3UTR	ENST00000469815	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-3UTR	ENST00000469815	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-intron	ENST00000469815	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-intron	ENST00000469815	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-intron	ENST00000469815	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-3UTR	ENST00000469815	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-3UTR	ENST00000469815	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-3UTR	ENST00000469815	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
3UTR-3UTR	ENST00000469815	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000526894	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000526894	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000526894	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000526894	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000526894	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000526894	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000526894	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000526894	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000526894	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000524618	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000524618	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000524618	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000524618	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000524618	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000524618	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000524618	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000524618	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000524618	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374307	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374307	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374307	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374307	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374307	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374307	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374307	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374307	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374307	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374301	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374301	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374301	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374301	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374301	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374301	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374301	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374301	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374301	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374300	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374300	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374300	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374300	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000374300	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374300	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374300	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374300	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000374300	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000466284	ENST00000374303	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000466284	ENST00000474295	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000466284	ENST00000469815	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000466284	ENST00000526894	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-intron	ENST00000466284	ENST00000524618	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000466284	ENST00000374307	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000466284	ENST00000374301	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000466284	ENST00000374300	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+
5CDS-3UTR	ENST00000466284	ENST00000466284	MTFR1L	chr1	26156224	-	MTFR1L	chr1	26159163	+

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FusionProtFeatures for MTFR1L_MTFR1L

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTFR1L Q9H019	MTFR1L Q9H019

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MTFR1L_MTFR1L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTFR1L_MTFR1L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MTFR1L_MTFR1L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MTFR1L_MTFR1L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 22750

FusionGeneSummary for MTFR1L_MTFR1L

FusionProtFeatures for MTFR1L_MTFR1L

FusionGeneSequence for MTFR1L_MTFR1L

FusionGenePPI for MTFR1L_MTFR1L

RelatedDrugs for MTFR1L_MTFR1L

RelatedDiseases for MTFR1L_MTFR1L