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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22749

FusionGeneSummary for MTFR1L_BROX

check button Fusion gene summary
Fusion gene informationFusion gene name: MTFR1L_BROX
Fusion gene ID: 22749
HgeneTgene
Gene symbol

MTFR1L

BROX

Gene ID

56181

148362

Gene namemitochondrial fission regulator 1 likeBRO1 domain and CAAX motif containing
SynonymsFAM54B|HYST1888|MST116|MSTP116C1orf58
Cytomap

1p36.11

1q41

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial fission regulator 1-likefamily with sequence similarity 54 member Bprotein FAM54BBRO1 domain-containing protein BROX
Modification date2018052320180519
UniProtAcc

Q9H019

Q5VW32

Ensembl transtripts involved in fusion geneENST00000374303, ENST00000474295, 
ENST00000469815, ENST00000526894, 
ENST00000524618, ENST00000374307, 
ENST00000374301, ENST00000374300, 
ENST00000466284, 
ENST00000340934, 
ENST00000496267, ENST00000537020, 
ENST00000539697, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: MTFR1L [Title/Abstract] AND BROX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF089900MTFR1Lchr1

26156304

-BROXchr1

222906016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000374303ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-intronENST00000374303ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374303ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374303ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3CDSENST00000474295ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-intronENST00000474295ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000474295ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000474295ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3CDSENST00000469815ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-intronENST00000469815ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000469815ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000469815ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3CDSENST00000526894ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-intronENST00000526894ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000526894ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000526894ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
In-frameENST00000524618ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-intronENST00000524618ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000524618ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000524618ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
In-frameENST00000374307ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-intronENST00000374307ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374307ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374307ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
In-frameENST00000374301ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-intronENST00000374301ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374301ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374301ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
In-frameENST00000374300ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-intronENST00000374300ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374300ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
5CDS-3UTRENST00000374300ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3CDSENST00000466284ENST00000340934MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-intronENST00000466284ENST00000496267MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000466284ENST00000537020MTFR1Lchr1

26156304

-BROXchr1

222906016

-
3UTR-3UTRENST00000466284ENST00000539697MTFR1Lchr1

26156304

-BROXchr1

222906016

-

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FusionProtFeatures for MTFR1L_BROX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTFR1L

Q9H019

BROX

Q5VW32


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTFR1L_BROX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MTFR1L_ENST00000374303_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0aa

>In-frame_MTFR1L_ENST00000524618_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0aa

>In-frame_MTFR1L_ENST00000374307_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0aa

>In-frame_MTFR1L_ENST00000374301_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0aa

>In-frame_MTFR1L_ENST00000374300_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MTFR1L_ENST00000374303_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000524618_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000374307_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000374301_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000374300_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_MTFR1L_ENST00000374303_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000524618_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000374307_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000374301_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt

>In-frame_MTFR1L_ENST00000374300_chr1_26156304_-_BROX_ENST00000340934_chr1_222906016_-_0nt


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FusionGenePPI for MTFR1L_BROX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTFR1L_BROX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTFR1L_BROX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource