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Fusion gene ID: 22744 |
FusionGeneSummary for MTF2_FAM69A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTF2_FAM69A | Fusion gene ID: 22744 | Hgene | Tgene | Gene symbol | MTF2 | FAM69A | Gene ID | 22823 | 388650 |
| Gene name | metal response element binding transcription factor 2 | family with sequence similarity 69 member A | |
| Synonyms | M96|PCL2|TDRD19A|dJ976O13.2 | - | |
| Cytomap | 1p22.1 | 1p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metal-response element-binding transcription factor 2hPCl2metal regulatory transcription factor 2metal-response element DNA-binding protein M96polycomb-like 2polycomb-like protein 2putative DNA binding proteintudor domain containing 19A | protein FAM69A | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y483 | Q5T7M9 | |
| Ensembl transtripts involved in fusion gene | ENST00000545708, ENST00000540243, ENST00000370298, ENST00000471953, ENST00000370303, | ENST00000370310, | |
| Fusion gene scores | * DoF score | 7 X 3 X 4=84 | 2 X 1 X 2=4 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MTF2 [Title/Abstract] AND FAM69A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1NA-01A | MTF2 | chr1 | 93545088 | + | FAM69A | chr1 | 93341987 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000545708 | ENST00000370310 | MTF2 | chr1 | 93545088 | + | FAM69A | chr1 | 93341987 | - |
| 5UTR-3CDS | ENST00000540243 | ENST00000370310 | MTF2 | chr1 | 93545088 | + | FAM69A | chr1 | 93341987 | - |
| Frame-shift | ENST00000370298 | ENST00000370310 | MTF2 | chr1 | 93545088 | + | FAM69A | chr1 | 93341987 | - |
| 3UTR-3CDS | ENST00000471953 | ENST00000370310 | MTF2 | chr1 | 93545088 | + | FAM69A | chr1 | 93341987 | - |
| Frame-shift | ENST00000370303 | ENST00000370310 | MTF2 | chr1 | 93545088 | + | FAM69A | chr1 | 93341987 | - |
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FusionProtFeatures for MTF2_FAM69A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTF2 | FAM69A |
| Polycomb group (PcG) that specifically binds histone H3trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2complex. Acts by binding to H3K36me3, a mark for transcriptionalactivation, and recruiting the PRC2 complex, leading to enhancePRC2 H3K27me3 methylation activity. Regulates the transcriptionalnetworks during embryonic stem cell self-renewal anddifferentiation. Promotes recruitment of the PRC2 complex to theinactive X chromosome in differentiating XX ES cells and PRC2recruitment to target genes in undifferentiated ES cells. Requiredto repress Hox genes by enhancing H3K27me3 methylation of the PRC2complex. In some conditions may act as an inhibitor of PRC2activity: able to activate the CDKN2A gene and promote cellularsenescence by suppressing the catalytic activity of the PRC2complex locally. Binds to the metal-regulating-element (MRE) ofMT1A gene promoter (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MTF2_FAM69A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MTF2_FAM69A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTF2 | EZH2, SUZ12, JARID2, CREB1, GSK3B, ELAVL1, SMAD3, PRKD2, TMED9, KDM1A, PRMT6, SUV39H1, SUV39H2, RBBP7, PIK3R3, JAK3, KIF2A, EED, TGDS, ADAM30 | FAM69A | CD1B, HSD11B1, A4GNT, POMK, ZACN, PLTP, HTR3C, CLEC2D, MPPE1, HTR3A, ST8SIA4, CD79B, PNLDC1, CD1E, CHRNA3, GRIA3, ASIC4, GGT7, C1orf85, NCEH1, IL17RC, TMED6, TMPRSS11B, B4GAT1, LYPD4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTF2_FAM69A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTF2_FAM69A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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