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Fusion gene ID: 22732 |
FusionGeneSummary for MTDH_MTDH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTDH_MTDH | Fusion gene ID: 22732 | Hgene | Tgene | Gene symbol | MTDH | MTDH | Gene ID | 92140 | 92140 |
| Gene name | metadherin | metadherin | |
| Synonyms | 3D3|AEG-1|AEG1|LYRIC|LYRIC/3D3 | 3D3|AEG-1|AEG1|LYRIC|LYRIC/3D3 | |
| Cytomap | 8q22.1 | 8q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein LYRIC3D3/LYRICastrocyte elevated gene 1astrocyte elevated gene-1 proteinlysine-rich CEACAM1 co-isolated proteinmetastasis adhesion protein | protein LYRIC3D3/LYRICastrocyte elevated gene 1astrocyte elevated gene-1 proteinlysine-rich CEACAM1 co-isolated proteinmetastasis adhesion protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86UE4 | Q86UE4 | |
| Ensembl transtripts involved in fusion gene | ENST00000336273, ENST00000519934, | ENST00000336273, ENST00000519934, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 3 X 4 X 1=12 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MTDH [Title/Abstract] AND MTDH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTDH | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15927426 |
| Hgene | MTDH | GO:0010508 | positive regulation of autophagy | 21127263 |
| Hgene | MTDH | GO:0043066 | negative regulation of apoptotic process | 17704808 |
| Hgene | MTDH | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 16452207|18316612 |
| Hgene | MTDH | GO:0045766 | positive regulation of angiogenesis | 19940250 |
| Hgene | MTDH | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 16452207|18316612 |
| Hgene | MTDH | GO:0051897 | positive regulation of protein kinase B signaling | 17704808 |
| Tgene | MTDH | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15927426 |
| Tgene | MTDH | GO:0010508 | positive regulation of autophagy | 21127263 |
| Tgene | MTDH | GO:0043066 | negative regulation of apoptotic process | 17704808 |
| Tgene | MTDH | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 16452207|18316612 |
| Tgene | MTDH | GO:0045766 | positive regulation of angiogenesis | 19940250 |
| Tgene | MTDH | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 16452207|18316612 |
| Tgene | MTDH | GO:0051897 | positive regulation of protein kinase B signaling | 17704808 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA171915 | MTDH | chr8 | 98735263 | + | MTDH | chr8 | 98703180 | + | ||
| ChiTaRS3.1 | BG166673 | MTDH | chr8 | 98738042 | - | MTDH | chr8 | 98738111 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336273 | ENST00000336273 | MTDH | chr8 | 98735263 | + | MTDH | chr8 | 98703180 | + |
| In-frame | ENST00000336273 | ENST00000519934 | MTDH | chr8 | 98735263 | + | MTDH | chr8 | 98703180 | + |
| In-frame | ENST00000519934 | ENST00000336273 | MTDH | chr8 | 98735263 | + | MTDH | chr8 | 98703180 | + |
| In-frame | ENST00000519934 | ENST00000519934 | MTDH | chr8 | 98735263 | + | MTDH | chr8 | 98703180 | + |
| 3UTR-3UTR | ENST00000336273 | ENST00000336273 | MTDH | chr8 | 98738042 | - | MTDH | chr8 | 98738111 | + |
| 3UTR-intron | ENST00000336273 | ENST00000519934 | MTDH | chr8 | 98738042 | - | MTDH | chr8 | 98738111 | + |
| intron-3UTR | ENST00000519934 | ENST00000336273 | MTDH | chr8 | 98738042 | - | MTDH | chr8 | 98738111 | + |
| intron-intron | ENST00000519934 | ENST00000519934 | MTDH | chr8 | 98738042 | - | MTDH | chr8 | 98738111 | + |
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FusionProtFeatures for MTDH_MTDH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTDH | MTDH |
| Downregulates SLC1A2/EAAT2 promoter activity whenexpressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independentgrowth of immortalized melanocytes and astrocytes which is a keycomponent in tumor cell expansion. Promotes lung metastasis andalso has an effect on bone and brain metastasis, possibly byenhancing the seeding of tumor cells to the target organendothelium. Induces chemoresistance.{ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207,ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. | Downregulates SLC1A2/EAAT2 promoter activity whenexpressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independentgrowth of immortalized melanocytes and astrocytes which is a keycomponent in tumor cell expansion. Promotes lung metastasis andalso has an effect on bone and brain metastasis, possibly byenhancing the seeding of tumor cells to the target organendothelium. Induces chemoresistance.{ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207,ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 441_451 | 559 | 583 | Compositional bias | Note=Poly-Lys |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 59_67 | 559 | 583 | Compositional bias | Note=Poly-Leu |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 1_71 | 559 | 583 | Region | Note=Activation of NF-kappa-B |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 381_443 | 559 | 583 | Region | Lung-homing for mammary tumors |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 1_48 | 559 | 583 | Topological domain | Lumenal |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 49_69 | 559 | 583 | Transmembrane | Helical |
| Tgene | >MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 441_451 | 270 | 583 | Compositional bias | Note=Poly-Lys |
| Tgene | >MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 573_577 | 270 | 583 | Compositional bias | Note=Poly-Lys |
| Tgene | >MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 381_443 | 270 | 583 | Region | Lung-homing for mammary tumors |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 573_577 | 559 | 583 | Compositional bias | Note=Poly-Lys |
| Hgene | >MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 70_582 | 559 | 583 | Topological domain | Cytoplasmic |
| Tgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 59_67 | 270 | 583 | Compositional bias | Note=Poly-Leu |
| Tgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 1_71 | 270 | 583 | Region | Note=Activation of NF-kappa-B |
| Tgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 1_48 | 270 | 583 | Topological domain | Lumenal |
| Tgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 70_582 | 270 | 583 | Topological domain | Cytoplasmic |
| Tgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 49_69 | 270 | 583 | Transmembrane | Helical |
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FusionGeneSequence for MTDH_MTDH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MTDH_MTDH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTDH | OTUD6B, MME, CUL3, ZBTB16, PLEC, ESR1, RELA, CREBBP, CSNK2A1, LMNA, TARDBP, TOPORS, CCDC8, RNF2, SIRT2, NR2E1, ACTL6A, NTRK1, TMEM237, TMEM216, EXOSC4, BTRC, SNN, SND1, MTUS2, ZYG11B, JUN, EP300 | MTDH | OTUD6B, MME, CUL3, ZBTB16, PLEC, ESR1, RELA, CREBBP, CSNK2A1, LMNA, TARDBP, TOPORS, CCDC8, RNF2, SIRT2, NR2E1, ACTL6A, NTRK1, TMEM237, TMEM216, EXOSC4, BTRC, SNN, SND1, MTUS2, ZYG11B, JUN, EP300 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 72_169 | 559 | 583 | BCCIP |
| Hgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 11 | 12 | 101_205 | 559 | 583 | RELA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 72_169 | 270 | 583 | BCCIP |
| Tgene | MTDH | chr8:98735263 | chr8:98703180 | ENST00000336273 | + | 4 | 12 | 101_205 | 270 | 583 | RELA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTDH_MTDH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTDH_MTDH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MTDH | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | MTDH | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | MTDH | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | MTDH | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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