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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22716

FusionGeneSummary for MTAP_PTPRD

check button Fusion gene summary
Fusion gene informationFusion gene name: MTAP_PTPRD
Fusion gene ID: 22716
HgeneTgene
Gene symbol

MTAP

PTPRD

Gene ID

4507

5789

Gene namemethylthioadenosine phosphorylaseprotein tyrosine phosphatase, receptor type D
SynonymsBDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fusHPTP|HPTPD|HPTPDELTA|PTPD|RPTPDELTA
Cytomap

9p21.3

9p24.1-p23

Type of geneprotein-codingprotein-coding
DescriptionS-methyl-5'-thioadenosine phosphorylase5'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPaseMeSAdo phosphorylaseepididymis luminal protein 249receptor-type tyrosine-protein phosphatase deltaR-PTP-deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase delta
Modification date2018052320180522
UniProtAcc

Q13126

P23468

Ensembl transtripts involved in fusion geneENST00000580900, ENST00000380172, 
ENST00000460874, ENST00000427788, 
ENST00000381196, ENST00000360074, 
ENST00000537002, ENST00000397617, 
ENST00000358503, ENST00000397611, 
ENST00000355233, ENST00000356435, 
ENST00000540109, ENST00000486161, 
ENST00000397606, ENST00000463477, 
ENST00000471274, 
Fusion gene scores* DoF score7 X 6 X 7=29413 X 12 X 8=1248
# samples 913
** MAII scorelog2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1248*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTAP [Title/Abstract] AND PTPRD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTAP

GO:0006738

nicotinamide riboside catabolic process

19001417


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-US-A779-01AMTAPchr9

21838009

+PTPRDchr9

9766851

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000580900ENST00000381196MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000360074MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000537002MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000397617MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000358503MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000397611MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000355233MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000356435MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000540109MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000486161MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000397606MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-5UTRENST00000580900ENST00000463477MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000580900ENST00000471274MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-5UTRENST00000380172ENST00000381196MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000360074MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000537002MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000397617MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000358503MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000397611MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000355233MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000356435MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000540109MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000486161MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000397606MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-5UTRENST00000380172ENST00000463477MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000380172ENST00000471274MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-5UTRENST00000460874ENST00000381196MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000360074MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000537002MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000397617MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000358503MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000397611MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000355233MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000356435MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000540109MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000486161MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000397606MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-5UTRENST00000460874ENST00000463477MTAPchr9

21838009

+PTPRDchr9

9766851

-
5CDS-intronENST00000460874ENST00000471274MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-5UTRENST00000427788ENST00000381196MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000360074MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000537002MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000397617MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000358503MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000397611MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000355233MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000356435MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000540109MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000486161MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000397606MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-5UTRENST00000427788ENST00000463477MTAPchr9

21838009

+PTPRDchr9

9766851

-
intron-intronENST00000427788ENST00000471274MTAPchr9

21838009

+PTPRDchr9

9766851

-

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FusionProtFeatures for MTAP_PTPRD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTAP

Q13126

PTPRD

P23468

Can bidirectionally induce pre- and post-synapticdifferentiation of neurons by mediating interaction with IL1RAPand IL1RAPL1 trans-synaptically. Involved in pre-synapticdifferentiation through interaction with SLITRK2.{ECO:0000250|UniProtKB:Q64487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTAP_PTPRD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTAP_PTPRD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTAPELAVL1, FOLH1, CDC25A, RELB, LYRM1, ANXA6, ATP6V1A, CUTA, CFL1, GOT1, UBE2H, CHRAC1, GMPS, HPRT1, PNP, UROD, MTPN, PDIA3, RAB1A, FUS, CENPH, ARF4, ASS1, CARKD, CSE1L, EIF2B1, FAM49B, GLRX, GNPDA2, HINT1, LYPLA2, CNN2, DAZAP1, PCMT1, PPIL3, RBM12, SNX12, SNX3, SUMO3, SUMO4, TAGLN2, TAGLN3, TALDO1, UBE2D2, UFM1, CEP170, SCLT1, MCM2, TRIM25PTPRDPPFIA1, PTPRS, LPAR6, IL2RG, SCN2B, LRRTM2, PPFIA2, PPFIA3, EGFR, COPG2, HADHA, HADHB, TPP2, DSC3, TRIO, LRRN1, PCDHB16, PIANP, LITAF, CD83, ICOSLG, PMEL, PCDH20, IZUMO1, GPR37, ABCG8, PCDHGB4, LILRB4, C19orf45, ARHGAP36, IL17RD, LINGO2, FYN, STMN4, MILR1, TMEM52B, RPL28, TPCN2, TMEM223, NLGN3, IL20RA, MTNR1A, MTNR1B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MTAP_PTPRD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTAP_PTPRD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTAPC0025202melanoma1CTD_human
HgeneMTAPC0027960Nevus1CTD_human
HgeneMTAPC0033578Prostatic Neoplasms1CTD_human
TgenePTPRDC0009404Colorectal Neoplasms2CTD_human
TgenePTPRDC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePTPRDC0035258Restless Legs Syndrome1CTD_human
TgenePTPRDC1263846Attention deficit hyperactivity disorder1CTD_human
TgenePTPRDC1458155Mammary Neoplasms1CTD_human