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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22713

FusionGeneSummary for MTAP_LINGO2

check button Fusion gene summary
Fusion gene informationFusion gene name: MTAP_LINGO2
Fusion gene ID: 22713
HgeneTgene
Gene symbol

MTAP

LINGO2

Gene ID

4507

158038

Gene namemethylthioadenosine phosphorylaseleucine rich repeat and Ig domain containing 2
SynonymsBDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fusLERN3|LRRN6C
Cytomap

9p21.3

9p21.2-p21.1

Type of geneprotein-codingprotein-coding
DescriptionS-methyl-5'-thioadenosine phosphorylase5'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPaseMeSAdo phosphorylaseepididymis luminal protein 249leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2leucine rich repeat neuronal 6Cleucine-rich repeat neuronal protein 3leucine-rich repeat neuronal protein 6C
Modification date2018052320180523
UniProtAcc

Q13126

Q7L985

Ensembl transtripts involved in fusion geneENST00000580900, ENST00000380172, 
ENST00000460874, ENST00000427788, 
ENST00000379992, ENST00000493941, 
ENST00000308675, 
Fusion gene scores* DoF score7 X 6 X 7=2947 X 4 X 6=168
# samples 99
** MAII scorelog2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTAP [Title/Abstract] AND LINGO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTAP

GO:0006738

nicotinamide riboside catabolic process

19001417


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FJ-A871-01AMTAPchr9

21838009

+LINGO2chr9

27950704

-
TCGALDBLCATCGA-FJ-A871-01AMTAPchr9

21838009

+LINGO2chr9

28080976

-
TCGARVMESOTCGA-LK-A4O5-01AMTAPchr9

21854869

+LINGO2chr9

28476023

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000580900ENST00000379992MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-intronENST00000580900ENST00000493941MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-5UTRENST00000580900ENST00000308675MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-5UTRENST00000380172ENST00000379992MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-intronENST00000380172ENST00000493941MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-5UTRENST00000380172ENST00000308675MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-5UTRENST00000460874ENST00000379992MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-intronENST00000460874ENST00000493941MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-5UTRENST00000460874ENST00000308675MTAPchr9

21838009

+LINGO2chr9

27950704

-
intron-5UTRENST00000427788ENST00000379992MTAPchr9

21838009

+LINGO2chr9

27950704

-
intron-intronENST00000427788ENST00000493941MTAPchr9

21838009

+LINGO2chr9

27950704

-
intron-5UTRENST00000427788ENST00000308675MTAPchr9

21838009

+LINGO2chr9

27950704

-
5CDS-intronENST00000580900ENST00000379992MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-5UTRENST00000580900ENST00000493941MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-intronENST00000580900ENST00000308675MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-intronENST00000380172ENST00000379992MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-5UTRENST00000380172ENST00000493941MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-intronENST00000380172ENST00000308675MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-intronENST00000460874ENST00000379992MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-5UTRENST00000460874ENST00000493941MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-intronENST00000460874ENST00000308675MTAPchr9

21838009

+LINGO2chr9

28080976

-
intron-intronENST00000427788ENST00000379992MTAPchr9

21838009

+LINGO2chr9

28080976

-
intron-5UTRENST00000427788ENST00000493941MTAPchr9

21838009

+LINGO2chr9

28080976

-
intron-intronENST00000427788ENST00000308675MTAPchr9

21838009

+LINGO2chr9

28080976

-
5CDS-5UTRENST00000580900ENST00000379992MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-intronENST00000580900ENST00000493941MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-intronENST00000580900ENST00000308675MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-5UTRENST00000380172ENST00000379992MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-intronENST00000380172ENST00000493941MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-intronENST00000380172ENST00000308675MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-5UTRENST00000460874ENST00000379992MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-intronENST00000460874ENST00000493941MTAPchr9

21854869

+LINGO2chr9

28476023

-
5CDS-intronENST00000460874ENST00000308675MTAPchr9

21854869

+LINGO2chr9

28476023

-
intron-5UTRENST00000427788ENST00000379992MTAPchr9

21854869

+LINGO2chr9

28476023

-
intron-intronENST00000427788ENST00000493941MTAPchr9

21854869

+LINGO2chr9

28476023

-
intron-intronENST00000427788ENST00000308675MTAPchr9

21854869

+LINGO2chr9

28476023

-

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FusionProtFeatures for MTAP_LINGO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTAP

Q13126

LINGO2

Q7L985


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTAP_LINGO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTAP_LINGO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTAPELAVL1, FOLH1, CDC25A, RELB, LYRM1, ANXA6, ATP6V1A, CUTA, CFL1, GOT1, UBE2H, CHRAC1, GMPS, HPRT1, PNP, UROD, MTPN, PDIA3, RAB1A, FUS, CENPH, ARF4, ASS1, CARKD, CSE1L, EIF2B1, FAM49B, GLRX, GNPDA2, HINT1, LYPLA2, CNN2, DAZAP1, PCMT1, PPIL3, RBM12, SNX12, SNX3, SUMO3, SUMO4, TAGLN2, TAGLN3, TALDO1, UBE2D2, UFM1, CEP170, SCLT1, MCM2, TRIM25LINGO2APP, LINGO1, SMURF2, LGALS1, SLC34A2, GAPDHS, PTPRD, STK11IP, LMAN2L, TRIM11, CNPY3, CARKD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTAP_LINGO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTAP_LINGO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTAPC0025202melanoma1CTD_human
HgeneMTAPC0027960Nevus1CTD_human
HgeneMTAPC0033578Prostatic Neoplasms1CTD_human
TgeneLINGO2C0023903Liver neoplasms1CTD_human
TgeneLINGO2C0236733Amphetamine-Related Disorders1CTD_human