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Fusion gene ID: 22691 |
FusionGeneSummary for MST1_SRRD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MST1_SRRD | Fusion gene ID: 22691 | Hgene | Tgene | Gene symbol | MST1 | SRRD | Gene ID | 6789 | 402055 |
| Gene name | serine/threonine kinase 4 | SRR1 domain containing | |
| Synonyms | KRS2|MST1|YSK3 | HC/HCC|SRR1L | |
| Cytomap | 20q13.12 | 22q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase 4STE20-like kinase MST1kinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2 | SRR1-like proteinSRR1 domain-containing proteinhepatocellular carcinoma complicating hemochromatosis | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P26927 | Q9UH36 | |
| Ensembl transtripts involved in fusion gene | ENST00000449682, ENST00000383728, ENST00000545762, ENST00000494828, | ENST00000215917, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MST1 [Title/Abstract] AND SRRD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MST1 | GO:0000902 | cell morphogenesis | 11805089 |
| Hgene | MST1 | GO:0001934 | positive regulation of protein phosphorylation | 19962960 |
| Hgene | MST1 | GO:0006468 | protein phosphorylation | 8566796|11805089 |
| Hgene | MST1 | GO:0006915 | apoptotic process | 21212262 |
| Hgene | MST1 | GO:0018105 | peptidyl-serine phosphorylation | 16751106 |
| Hgene | MST1 | GO:0032092 | positive regulation of protein binding | 22292086 |
| Hgene | MST1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19962960 |
| Hgene | MST1 | GO:0035329 | hippo signaling | 20412773 |
| Hgene | MST1 | GO:0035556 | intracellular signal transduction | 8566796 |
| Hgene | MST1 | GO:0043065 | positive regulation of apoptotic process | 15109305 |
| Hgene | MST1 | GO:0046777 | protein autophosphorylation | 11805089 |
| Hgene | MST1 | GO:0050821 | protein stabilization | 19962960 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0D2-01A | MST1 | chr3 | 49721747 | - | SRRD | chr22 | 26883995 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000449682 | ENST00000215917 | MST1 | chr3 | 49721747 | - | SRRD | chr22 | 26883995 | + |
| intron-3CDS | ENST00000383728 | ENST00000215917 | MST1 | chr3 | 49721747 | - | SRRD | chr22 | 26883995 | + |
| intron-3CDS | ENST00000545762 | ENST00000215917 | MST1 | chr3 | 49721747 | - | SRRD | chr22 | 26883995 | + |
| intron-3CDS | ENST00000494828 | ENST00000215917 | MST1 | chr3 | 49721747 | - | SRRD | chr22 | 26883995 | + |
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FusionProtFeatures for MST1_SRRD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MST1 | SRRD |
| May be involved in a circadian clock input pathway.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MST1_SRRD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MST1_SRRD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MST1 | FOXO1, RASSF1 | SRRD | MOV10, NXF1, XPO1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MST1_SRRD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MST1_SRRD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MST1 | C0009324 | Ulcerative Colitis | 2 | CTD_human |
| Hgene | MST1 | C0008313 | Cholangitis, Sclerosing | 1 | CTD_human |
| Hgene | MST1 | C0010346 | Crohn Disease | 1 | CTD_human |
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