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Fusion gene ID: 22665 |
FusionGeneSummary for MSMB_KLK3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MSMB_KLK3 | Fusion gene ID: 22665 | Hgene | Tgene | Gene symbol | MSMB | KLK3 | Gene ID | 4477 | 354 |
Gene name | microseminoprotein beta | kallikrein related peptidase 3 | |
Synonyms | HPC13|IGBF|MSP|MSPB|PN44|PRPS|PSP|PSP-94|PSP57|PSP94 | APS|KLK2A1|PSA|hK3 | |
Cytomap | 10q11.22 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | beta-microseminoproteinimmunoglobulin binding factorprostate secreted seminal plasma proteinprostate secretory protein of 94 amino acidsseminal plasma beta-inhibin | prostate-specific antigenP-30 antigengamma-seminoproteinkallikrein-3semenogelaseseminin | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P08118 | P07288 | |
Ensembl transtripts involved in fusion gene | ENST00000358559, ENST00000474170, ENST00000298239, | ENST00000326003, ENST00000597483, ENST00000593997, ENST00000595952, ENST00000360617, | |
Fusion gene scores | * DoF score | 3 X 2 X 1=6 | 11 X 8 X 2=176 |
# samples | 4 | 13 | |
** MAII score | log2(4/6*10)=2.73696559416621 | log2(13/176*10)=-0.437063805608843 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MSMB [Title/Abstract] AND KLK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KLK3 | GO:0002778 | antibacterial peptide production | 18714013 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-J9-A52B-01A | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
TCGA | RV | PRAD | TCGA-J4-A67O-01A | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000358559 | ENST00000326003 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000358559 | ENST00000597483 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000358559 | ENST00000593997 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000358559 | ENST00000595952 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000358559 | ENST00000360617 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
intron-3CDS | ENST00000474170 | ENST00000326003 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
intron-intron | ENST00000474170 | ENST00000597483 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
intron-intron | ENST00000474170 | ENST00000593997 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
intron-intron | ENST00000474170 | ENST00000595952 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
intron-intron | ENST00000474170 | ENST00000360617 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
In-frame | ENST00000298239 | ENST00000326003 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000298239 | ENST00000597483 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000298239 | ENST00000593997 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000298239 | ENST00000595952 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
5CDS-intron | ENST00000298239 | ENST00000360617 | MSMB | chr10 | 51562517 | + | KLK3 | chr19 | 51361285 | + |
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FusionProtFeatures for MSMB_KLK3 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MSMB | KLK3 |
Hydrolyzes semenogelin-1 thus leading to theliquefaction of the seminal coagulum. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MSMB_KLK3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MSMB_ENST00000298239_chr10_51562517_+_KLK3_ENST00000326003_chr19_51361285_+_310aa MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRMFLHLWVMTKTTAKESSRRRTASISWWRRRTQKRPVLSVNGXSNVLLVGTGLPG QASFSSGLXXSMIVXPCLSVKRFLSKHKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAEL TDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGV |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MSMB_ENST00000298239_chr10_51562517_+_KLK3_ENST00000326003_chr19_51361285_+_930nt ATGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTT CCAGGAGATTCAACCAGGATGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATA TCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGC CAGGCCTCATTCTCCTCTGGCCTCTAATAGTCAATGATTGTGTAGCCATGCCTATCAGTAAAAAGATTTTTGAGCAAACACAAAAGCGTG ATCTTGCTGGGTCGGCACAGCCTGTTTCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTCTACGAT ATGAGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTC ACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCA GAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTG ACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTGATTCTGGGGGCCCACTTGTCTGTAATGGTGTG CTTCAAGGTATCACGTCATGGGGCAGTGAACCATGTGCCCTGCCCGAAAGGCCTTCCCTGTACACCAAGGTGGTGCATTACCGGAAGTGG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MSMB_ENST00000298239_chr10_51562517_+_KLK3_ENST00000326003_chr19_51361285_+_1598nt GTACCTGTCTATAAGGAGTCCTGCTTATCACAATGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTATGCAATG CATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGATGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCA AAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTA ATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTAATAGTCAATGATTGTGTAGCCATGCCTATCAG TAAAAAGATTTTTGAGCAAACACAAAAGCGTGATCTTGCTGGGTCGGCACAGCCTGTTTCATCCTGAAGACACAGGCCAGGTATTTCAGG TCAGCCACAGCTTCCCACACCCGCTCTACGATATGAGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCA TGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCT GCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATG ACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTG ATTCTGGGGGCCCACTTGTCTGTAATGGTGTGCTTCAAGGTATCACGTCATGGGGCAGTGAACCATGTGCCCTGCCCGAAAGGCCTTCCC TGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGGACACCATCGTGGCCAACCCCTGAGCACCCCTATCAACCCCCTATTGTAGTA AACTTGGAACCTTGGAAATGACCAGGCCAAGACTCAAGCCTCCCCAGTTCTACTGACCTTTGTCCTTAGGTGTGAGGTCCAGGGTTGCTA GGAAAAGAAATCAGCAGACACAGGTGTAGACCAGAGTGTTTCTTAAATGGTGTAATTTTGTCCTCTCTGTGTCCTGGGGAATACTGGCCA TGCCTGGAGACATATCACTCAATTTCTCTGAGGACACAGATAGGATGGGGTGTCTGTGTTATTTGTGGGGTACAGAGATGAAAGAGGGGT GGGATCCACACTGAGAGAGTGGAGAGTGACATGTGCTGGACACTGTCCATGAAGCACTGAGCAGAAGCTGGAGGCACAACGCACCAGACA CTCACAGCAAGGATGGAGCTGAAAACATAACCCACTCTGTCCTGGAGGCACTGGGAAGCCTAGAGAAGGCTGTGAGCCAAGGAGGGAGGG TCTTCCTTTGGCATGGGATGGGGATGAAGTAAGGAGAGGGACTGGACCCCCTGGAAGCTGATTCACTATGGGGGGAGGTGTATTGAAGTC |
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FusionGenePPI for MSMB_KLK3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MSMB | APP, SGTA | KLK3 | SERPINA1, A2M, SERPINA5, ALB, UBA52, HSPA5, MIF4GD, AR, FN1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSMB_KLK3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | KLK3 | P07288 | DB00834 | Mifepristone | Prostate-specific antigen | small molecule | approved|investigational |
Tgene | KLK3 | P07288 | DB04839 | Cyproterone acetate | Prostate-specific antigen | small molecule | approved|investigational |
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RelatedDiseases for MSMB_KLK3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MSMB | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
Tgene | KLK3 | C0033578 | Prostatic Neoplasms | 10 | CTD_human |
Tgene | KLK3 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | KLK3 | C1334615 | Malignant Phyllodes Tumor of Prostate | 1 | CTD_human |
Tgene | KLK3 | C2937421 | Prostatic Hyperplasia | 1 | CTD_human |