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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22660

FusionGeneSummary for MSL2_UBASH3B

check button Fusion gene summary
Fusion gene informationFusion gene name: MSL2_UBASH3B
Fusion gene ID: 22660
HgeneTgene
Gene symbol

MSL2

UBASH3B

Gene ID

55167

84959

Gene nameMSL complex subunit 2ubiquitin associated and SH3 domain containing B
SynonymsMSL-2|MSL2L1|RNF184STS-1|STS1|TULA-2|TULA2|p70
Cytomap

3q22.3

11q24.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MSL2E3 ubiquitin-protein transferase MSL2MSL2-like 1male-specific lethal 2 homologmale-specific lethal 2-like 1male-specific lethal-2 homolog 1ring finger protein 184ubiquitin-associated and SH3 domain-containing protein BCbl-interacting protein Sts-1SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrateT-cell ubiquitin ligand 2cbl-interacting protein
Modification date2018052320180523
UniProtAcc

Q9HCI7

Q8TF42

Ensembl transtripts involved in fusion geneENST00000309993, ENST00000434835, 
ENST00000284273, ENST00000525711, 
Fusion gene scores* DoF score7 X 3 X 8=1682 X 2 X 2=8
# samples 92
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MSL2 [Title/Abstract] AND UBASH3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSL2

GO:0043984

histone H4-K16 acetylation

20018852


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-AA6A-01AMSL2chr3

135913814

-UBASH3Bchr11

122669650

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000309993ENST00000284273MSL2chr3

135913814

-UBASH3Bchr11

122669650

+
5CDS-intronENST00000309993ENST00000525711MSL2chr3

135913814

-UBASH3Bchr11

122669650

+
intron-3CDSENST00000434835ENST00000284273MSL2chr3

135913814

-UBASH3Bchr11

122669650

+
intron-intronENST00000434835ENST00000525711MSL2chr3

135913814

-UBASH3Bchr11

122669650

+

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FusionProtFeatures for MSL2_UBASH3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSL2

Q9HCI7

UBASH3B

Q8TF42

Component of histone acetyltransferase complexresponsible for the majority of histone H4 acetylation at lysine16 which is implicated in the formation of higher-order chromatinstructure. Acts as an E3 ubiquitin ligase that promotesmonoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but notthat of H2A. This activity is greatly enhanced byheterodimerization with MSL1. H2B ubiquitination in turnstimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79'(H3K79me) and leads to gene activation, including that of HOXA9and MEIS1. {ECO:0000269|PubMed:21726816}. Interferes with CBL-mediated down-regulation anddegradation of receptor-type tyrosine kinases. Promotesaccumulation of activated target receptors, such as T-cellreceptors and EGFR, on the cell surface. Exhibits tyrosinephosphatase activity toward several substrates including EGFR,FAK, SYK, and ZAP70. Down-regulates proteins that are duallymodified by both protein tyrosine phosphorylation andubiquitination. {ECO:0000269|PubMed:15159412,ECO:0000269|PubMed:17880946}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MSL2_UBASH3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MSL2_UBASH3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MSL2YWHAG, YWHAE, YWHAZ, KAT8, MSL1, MSL3, TP53, HIST2H2AC, HIST2H2AA3, HIST2H2BE, HIST2H3C, HIST1H4A, UBE2D3, MMS19, TRIM8, RNF40, RNF20, PAF1, CDK9, FAM96B, HBB, HBA2, IGHG2, TRIM25UBASH3BUBE2D1, UBE2D3, UBE2H, UBE2E1, UBE2C, UBE2D2, CBL, EGFR, UBC, SAP30, HDAC1, CHD4, ELAVL1, KHDRBS1, SYK, NCK1, INPP5D, GRB2, PARK2, ABL1, KRT10, KRT1, KRT2, CSK, KRT9, SPTBN1, KRT5, KRT14, KRT6B, HSPA8, KRT6A, ACTB, ARAP1, TUBB, KRT16, BCR, HSP90AB1, CRK, IQGAP1, KRT17, INPPL1, TUBA1B, MYH10, HSP90AA1, MYO1D, SPTA1, SPTAN1, KRT79, CCT3, ACTN4, CCT8, KRT8, HSPA1L, HSPA1B, KRT73, EEF1A1P5, ACACA, HSPA5, DSC1, KRT4, CCT7, CORO1C, DDX6, TCP1, UBASH3A, HSPA7, DCD, CCT6A, MCCC2, DNAJA1, MYH9, CCT6B, SHC1, ACTG1, ERRFI1, GFAP, HNRNPH1, HNRNPH2, HNRNPF, HNRNPU, HNRNPA2B1, RPS27A, S100A8, UBASH3B, DOC2A, CBLB, DAZAP2, SPRY2, FAM168A, RCHY1, DMRT3, VPS37B, SLC25A48, MAPT, MAP3K1, TMEM255A, FAM209A, PKP4, AURKB, CUL3, KIF20A, EWSR1, HIST1H1A, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H1T, LGALS3BP, ESRRB, RNF41, CCDC33, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSL2_UBASH3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSL2_UBASH3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource