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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22644

FusionGeneSummary for MSI2_TOB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MSI2_TOB1
Fusion gene ID: 22644
HgeneTgene
Gene symbol

MSI2

TOB1

Gene ID

124540

10140

Gene namemusashi RNA binding protein 2transducer of ERBB2, 1
SynonymsMSI2HAPRO5|APRO6|PIG49|TOB|TROB|TROB1
Cytomap

17q22

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein Musashi homolog 2musashi homolog 2musashi-2protein Tob1proliferation-inducing gene 49transducer of erbB-2 1
Modification date2018052320180523
UniProtAcc

Q96DH6

P50616

Ensembl transtripts involved in fusion geneENST00000416426, ENST00000284073, 
ENST00000322684, ENST00000442934, 
ENST00000579180, ENST00000579505, 
ENST00000499247, ENST00000268957, 
ENST00000509385, 
Fusion gene scores* DoF score29 X 8 X 12=27843 X 3 X 2=18
# samples 293
** MAII scorelog2(29/2784*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MSI2 [Title/Abstract] AND TOB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTOB1

GO:0008285

negative regulation of cell proliferation

8632892|19276069

TgeneTOB1

GO:0017148

negative regulation of translation

23236473

TgeneTOB1

GO:0060212

negative regulation of nuclear-transcribed mRNA poly(A) tail shortening

18377426

TgeneTOB1

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

21336257

TgeneTOB1

GO:1900153

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

21336257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LD-A9QF-01AMSI2chr17

55704664

+TOB1chr17

48944963

-
TCGALDBRCATCGA-LD-A9QF-01AMSI2chr17

55704664

+TOB1chr17

48941524

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000416426ENST00000499247MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-5UTRENST00000416426ENST00000268957MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000416426ENST00000509385MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000284073ENST00000499247MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-5UTRENST00000284073ENST00000268957MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000284073ENST00000509385MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000322684ENST00000499247MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-5UTRENST00000322684ENST00000268957MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000322684ENST00000509385MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000442934ENST00000499247MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-5UTRENST00000442934ENST00000268957MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000442934ENST00000509385MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000579180ENST00000499247MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-5UTRENST00000579180ENST00000268957MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-intronENST00000579180ENST00000509385MSI2chr17

55704664

+TOB1chr17

48944963

-
3UTR-intronENST00000579505ENST00000499247MSI2chr17

55704664

+TOB1chr17

48944963

-
3UTR-5UTRENST00000579505ENST00000268957MSI2chr17

55704664

+TOB1chr17

48944963

-
3UTR-intronENST00000579505ENST00000509385MSI2chr17

55704664

+TOB1chr17

48944963

-
5CDS-5UTRENST00000416426ENST00000499247MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000416426ENST00000268957MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-intronENST00000416426ENST00000509385MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000284073ENST00000499247MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000284073ENST00000268957MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-intronENST00000284073ENST00000509385MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000322684ENST00000499247MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000322684ENST00000268957MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-intronENST00000322684ENST00000509385MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000442934ENST00000499247MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000442934ENST00000268957MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-intronENST00000442934ENST00000509385MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000579180ENST00000499247MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-5UTRENST00000579180ENST00000268957MSI2chr17

55704664

+TOB1chr17

48941524

-
5CDS-intronENST00000579180ENST00000509385MSI2chr17

55704664

+TOB1chr17

48941524

-
3UTR-5UTRENST00000579505ENST00000499247MSI2chr17

55704664

+TOB1chr17

48941524

-
3UTR-5UTRENST00000579505ENST00000268957MSI2chr17

55704664

+TOB1chr17

48941524

-
3UTR-intronENST00000579505ENST00000509385MSI2chr17

55704664

+TOB1chr17

48941524

-

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FusionProtFeatures for MSI2_TOB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSI2

Q96DH6

TOB1

P50616

RNA binding protein that regulates the expression oftarget mRNAs at the translation level. May play a role in theproliferation and maintenance of stem cells in the central nervoussystem (By similarity). {ECO:0000250}. Anti-proliferative protein; the function is mediated byassociation with deadenylase subunits of the CCR4-NOT complex(PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNAdeadenylation by binding to CPEB3 and recruiting CNOT7 which leadsto target mRNA deadenylation and decay (PubMed:21336257).{ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473,ECO:0000269|PubMed:8632892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MSI2_TOB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MSI2_TOB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MSI2GRB2, H2AFX, CUL3, VCAM1, SOX2, TARDBP, RPA3, RPA2, RPA1, HNRNPH2, MEOX2, SUZ12, RNF2, BMI1, MRPL4, ICK, ANXA13, TIMM10B, RBFOX2, FKBP1A, CRIP1, CTSB, EIF3G, HNRNPA1, PABPC1, PABPC4, PIN1, STIP1, UFM1, WDR1, RAB7A, UBE2L3, NTRK1, CDK1, KIF21A, RHOBTB2, MDM2, TP53, ANKRD40, LOXL3, G3BP1, RNF157TOB1PABPC1, CNOT7, SCMH1, SETDB1, SMAD4, SMAD5, SMAD1, SMAD9, MARCKS, MAPK1, MAPK9, RPS6KA1, SKP2, CTNNB1, SMAD3, CORO7, ELAVL1, UBR5, CHAF1A, PAN2, CDC7, DTL, APP, NXF1, CNOT1, CNOT6, CNOT6L, CNOT2, TNKS1BP1, CNOT3, RQCD1, CNOT11, CNOT8, CNOT10, RAVER1, FHL2, RNF219, ATE1, FBXL13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSI2_TOB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSI2_TOB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTOB1C0014175Endometriosis1CTD_human
TgeneTOB1C0027659Neoplasms, Experimental1CTD_human
TgeneTOB1C0263454Chloracne1CTD_human