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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22627

FusionGeneSummary for MSI2_CCDC178

check button Fusion gene summary
Fusion gene informationFusion gene name: MSI2_CCDC178
Fusion gene ID: 22627
HgeneTgene
Gene symbol

MSI2

CCDC178

Gene ID

124540

374864

Gene namemusashi RNA binding protein 2coiled-coil domain containing 178
SynonymsMSI2HC18orf34
Cytomap

17q22

18q12.1

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein Musashi homolog 2musashi homolog 2musashi-2coiled-coil domain-containing protein 178
Modification date2018052320180329
UniProtAcc

Q96DH6

Q5BJE1

Ensembl transtripts involved in fusion geneENST00000416426, ENST00000284073, 
ENST00000322684, ENST00000442934, 
ENST00000579180, ENST00000579505, 
ENST00000581852, ENST00000403303, 
ENST00000383096, ENST00000300227, 
ENST00000579916, ENST00000406524, 
ENST00000583930, ENST00000402325, 
ENST00000579947, ENST00000583550, 
Fusion gene scores* DoF score29 X 8 X 12=27847 X 5 X 6=210
# samples 299
** MAII scorelog2(29/2784*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSI2 [Title/Abstract] AND CCDC178 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-5507-01AMSI2chr17

55339553

+CCDC178chr18

31020045

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000416426ENST00000581852MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000416426ENST00000403303MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000416426ENST00000383096MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000416426ENST00000300227MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000416426ENST00000579916MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000416426ENST00000406524MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000416426ENST00000583930MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000416426ENST00000402325MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000416426ENST00000579947MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000416426ENST00000583550MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000284073ENST00000581852MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000284073ENST00000403303MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000284073ENST00000383096MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000284073ENST00000300227MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000284073ENST00000579916MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000284073ENST00000406524MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000284073ENST00000583930MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000284073ENST00000402325MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000284073ENST00000579947MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000284073ENST00000583550MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000322684ENST00000581852MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000322684ENST00000403303MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000322684ENST00000383096MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000322684ENST00000300227MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000322684ENST00000579916MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000322684ENST00000406524MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000322684ENST00000583930MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-intronENST00000322684ENST00000402325MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000322684ENST00000579947MSI2chr17

55339553

+CCDC178chr18

31020045

-
5CDS-5UTRENST00000322684ENST00000583550MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000442934ENST00000581852MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000442934ENST00000403303MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000442934ENST00000383096MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000442934ENST00000300227MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000442934ENST00000579916MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000442934ENST00000406524MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000442934ENST00000583930MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000442934ENST00000402325MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000442934ENST00000579947MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000442934ENST00000583550MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579180ENST00000581852MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579180ENST00000403303MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579180ENST00000383096MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579180ENST00000300227MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579180ENST00000579916MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579180ENST00000406524MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579180ENST00000583930MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579180ENST00000402325MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579180ENST00000579947MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579180ENST00000583550MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579505ENST00000581852MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579505ENST00000403303MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579505ENST00000383096MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579505ENST00000300227MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579505ENST00000579916MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579505ENST00000406524MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579505ENST00000583930MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-intronENST00000579505ENST00000402325MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579505ENST00000579947MSI2chr17

55339553

+CCDC178chr18

31020045

-
intron-5UTRENST00000579505ENST00000583550MSI2chr17

55339553

+CCDC178chr18

31020045

-

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FusionProtFeatures for MSI2_CCDC178


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSI2

Q96DH6

CCDC178

Q5BJE1

RNA binding protein that regulates the expression oftarget mRNAs at the translation level. May play a role in theproliferation and maintenance of stem cells in the central nervoussystem (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MSI2_CCDC178


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MSI2_CCDC178


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MSI2GRB2, H2AFX, CUL3, VCAM1, SOX2, TARDBP, RPA3, RPA2, RPA1, HNRNPH2, MEOX2, SUZ12, RNF2, BMI1, MRPL4, ICK, ANXA13, TIMM10B, RBFOX2, FKBP1A, CRIP1, CTSB, EIF3G, HNRNPA1, PABPC1, PABPC4, PIN1, STIP1, UFM1, WDR1, RAB7A, UBE2L3, NTRK1, CDK1, KIF21A, RHOBTB2, MDM2, TP53, ANKRD40, LOXL3, G3BP1, RNF157CCDC178


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSI2_CCDC178


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSI2_CCDC178


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource