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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22625

FusionGeneSummary for MSI2_BRD7

check button Fusion gene summary
Fusion gene informationFusion gene name: MSI2_BRD7
Fusion gene ID: 22625
HgeneTgene
Gene symbol

MSI2

BRD7

Gene ID

124540

29117

Gene namemusashi RNA binding protein 2bromodomain containing 7
SynonymsMSI2HBP75|CELTIX1|NAG4
Cytomap

17q22

16q12.1

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein Musashi homolog 2musashi homolog 2musashi-2bromodomain-containing protein 775 kDa bromodomain proteinprotein CELTIX-1
Modification date2018052320180519
UniProtAcc

Q96DH6

Q9NPI1

Ensembl transtripts involved in fusion geneENST00000416426, ENST00000284073, 
ENST00000322684, ENST00000442934, 
ENST00000579180, ENST00000579505, 
ENST00000394688, ENST00000394689, 
ENST00000401491, 
Fusion gene scores* DoF score29 X 8 X 12=27842 X 2 X 2=8
# samples 292
** MAII scorelog2(29/2784*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MSI2 [Title/Abstract] AND BRD7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD7

GO:0006357

regulation of transcription by RNA polymerase II

12489984

TgeneBRD7

GO:0008285

negative regulation of cell proliferation

20228809

TgeneBRD7

GO:0035066

positive regulation of histone acetylation

20228809

TgeneBRD7

GO:0045892

negative regulation of transcription, DNA-templated

16265664

TgeneBRD7

GO:0045893

positive regulation of transcription, DNA-templated

20228809

TgeneBRD7

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

16265664


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-AA76-01AMSI2chr17

55607085

+BRD7chr16

50355949

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000416426ENST00000394688MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000416426ENST00000394689MSI2chr17

55607085

+BRD7chr16

50355949

-
5CDS-intronENST00000416426ENST00000401491MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000284073ENST00000394688MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000284073ENST00000394689MSI2chr17

55607085

+BRD7chr16

50355949

-
5CDS-intronENST00000284073ENST00000401491MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000322684ENST00000394688MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000322684ENST00000394689MSI2chr17

55607085

+BRD7chr16

50355949

-
5CDS-intronENST00000322684ENST00000401491MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000442934ENST00000394688MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000442934ENST00000394689MSI2chr17

55607085

+BRD7chr16

50355949

-
5CDS-intronENST00000442934ENST00000401491MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000579180ENST00000394688MSI2chr17

55607085

+BRD7chr16

50355949

-
Frame-shitENST00000579180ENST00000394689MSI2chr17

55607085

+BRD7chr16

50355949

-
5CDS-intronENST00000579180ENST00000401491MSI2chr17

55607085

+BRD7chr16

50355949

-
3UTR-3CDSENST00000579505ENST00000394688MSI2chr17

55607085

+BRD7chr16

50355949

-
3UTR-3CDSENST00000579505ENST00000394689MSI2chr17

55607085

+BRD7chr16

50355949

-
3UTR-intronENST00000579505ENST00000401491MSI2chr17

55607085

+BRD7chr16

50355949

-

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FusionProtFeatures for MSI2_BRD7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSI2

Q96DH6

BRD7

Q9NPI1

RNA binding protein that regulates the expression oftarget mRNAs at the translation level. May play a role in theproliferation and maintenance of stem cells in the central nervoussystem (By similarity). {ECO:0000250}. Acts both as coactivator and as corepressor. May play arole in chromatin remodeling. Activator of the Wnt signalingpathway in a DVL1-dependent manner by negatively regulating theGSK3B phosphotransferase activity. Induces dephosphorylation ofGSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation oftranscriptional activation by AR (By similarity). Transcriptionalcorepressor that down-regulates the expression of target genes.Binds to target promoters, leading to increased histone H3acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter.Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator forTP53-mediated activation of transcription of a set of targetgenes. Required for TP53-mediated cell-cycle arrest in response tooncogene activation. Promotes acetylation of TP53 at 'Lys-382',and thereby promotes efficient recruitment of TP53 to targetpromoters. Inhibits cell cycle progression from G1 to S phase.{ECO:0000250, ECO:0000269|PubMed:16265664,ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511,ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MSI2_BRD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MSI2_BRD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MSI2GRB2, H2AFX, CUL3, VCAM1, SOX2, TARDBP, RPA3, RPA2, RPA1, HNRNPH2, MEOX2, SUZ12, RNF2, BMI1, MRPL4, ICK, ANXA13, TIMM10B, RBFOX2, FKBP1A, CRIP1, CTSB, EIF3G, HNRNPA1, PABPC1, PABPC4, PIN1, STIP1, UFM1, WDR1, RAB7A, UBE2L3, NTRK1, CDK1, KIF21A, RHOBTB2, MDM2, TP53, ANKRD40, LOXL3, G3BP1, RNF157BRD7HNRNPUL1, AGR2, BHLHE40, FTH1, LAMA4, BTBD2, PAFAH1B3, PSMD11, RPLP1, SERPINB9, IRF2, BRCA1, POU2F1, PCBD1, RBFOX2, SMARCE1, BCL7C, ARID2, SMARCA4, SMARCC1, CHD7, SMARCC2, SMARCD1, TRIM24, TFAP4, BARD1, HAP1, LRIF1, NEFL, BRD2, HIST2H3C, DPF3, NUP50, TP53, EP300, GTF3C3, GTF3C5, PBRM1, MX1, HIST1H3E, REEP5, CDC5L, BCL7A, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSI2_BRD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSI2_BRD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource