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Fusion gene ID: 22625 |
FusionGeneSummary for MSI2_BRD7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSI2_BRD7 | Fusion gene ID: 22625 | Hgene | Tgene | Gene symbol | MSI2 | BRD7 | Gene ID | 124540 | 29117 |
| Gene name | musashi RNA binding protein 2 | bromodomain containing 7 | |
| Synonyms | MSI2H | BP75|CELTIX1|NAG4 | |
| Cytomap | 17q22 | 16q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2 | bromodomain-containing protein 775 kDa bromodomain proteinprotein CELTIX-1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96DH6 | Q9NPI1 | |
| Ensembl transtripts involved in fusion gene | ENST00000416426, ENST00000284073, ENST00000322684, ENST00000442934, ENST00000579180, ENST00000579505, | ENST00000394688, ENST00000394689, ENST00000401491, | |
| Fusion gene scores | * DoF score | 29 X 8 X 12=2784 | 2 X 2 X 2=8 |
| # samples | 29 | 2 | |
| ** MAII score | log2(29/2784*10)=-3.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MSI2 [Title/Abstract] AND BRD7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BRD7 | GO:0006357 | regulation of transcription by RNA polymerase II | 12489984 |
| Tgene | BRD7 | GO:0008285 | negative regulation of cell proliferation | 20228809 |
| Tgene | BRD7 | GO:0035066 | positive regulation of histone acetylation | 20228809 |
| Tgene | BRD7 | GO:0045892 | negative regulation of transcription, DNA-templated | 16265664 |
| Tgene | BRD7 | GO:0045893 | positive regulation of transcription, DNA-templated | 20228809 |
| Tgene | BRD7 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | 16265664 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-AA76-01A | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000416426 | ENST00000394688 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000416426 | ENST00000394689 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 5CDS-intron | ENST00000416426 | ENST00000401491 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000284073 | ENST00000394688 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000284073 | ENST00000394689 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 5CDS-intron | ENST00000284073 | ENST00000401491 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000322684 | ENST00000394688 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000322684 | ENST00000394689 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 5CDS-intron | ENST00000322684 | ENST00000401491 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000442934 | ENST00000394688 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000442934 | ENST00000394689 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 5CDS-intron | ENST00000442934 | ENST00000401491 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000579180 | ENST00000394688 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| Frame-shift | ENST00000579180 | ENST00000394689 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 5CDS-intron | ENST00000579180 | ENST00000401491 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 3UTR-3CDS | ENST00000579505 | ENST00000394688 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 3UTR-3CDS | ENST00000579505 | ENST00000394689 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
| 3UTR-intron | ENST00000579505 | ENST00000401491 | MSI2 | chr17 | 55607085 | + | BRD7 | chr16 | 50355949 | - |
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FusionProtFeatures for MSI2_BRD7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSI2 | BRD7 |
| RNA binding protein that regulates the expression oftarget mRNAs at the translation level. May play a role in theproliferation and maintenance of stem cells in the central nervoussystem (By similarity). {ECO:0000250}. | Acts both as coactivator and as corepressor. May play arole in chromatin remodeling. Activator of the Wnt signalingpathway in a DVL1-dependent manner by negatively regulating theGSK3B phosphotransferase activity. Induces dephosphorylation ofGSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation oftranscriptional activation by AR (By similarity). Transcriptionalcorepressor that down-regulates the expression of target genes.Binds to target promoters, leading to increased histone H3acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter.Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator forTP53-mediated activation of transcription of a set of targetgenes. Required for TP53-mediated cell-cycle arrest in response tooncogene activation. Promotes acetylation of TP53 at 'Lys-382',and thereby promotes efficient recruitment of TP53 to targetpromoters. Inhibits cell cycle progression from G1 to S phase.{ECO:0000250, ECO:0000269|PubMed:16265664,ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511,ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MSI2_BRD7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MSI2_BRD7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MSI2 | GRB2, H2AFX, CUL3, VCAM1, SOX2, TARDBP, RPA3, RPA2, RPA1, HNRNPH2, MEOX2, SUZ12, RNF2, BMI1, MRPL4, ICK, ANXA13, TIMM10B, RBFOX2, FKBP1A, CRIP1, CTSB, EIF3G, HNRNPA1, PABPC1, PABPC4, PIN1, STIP1, UFM1, WDR1, RAB7A, UBE2L3, NTRK1, CDK1, KIF21A, RHOBTB2, MDM2, TP53, ANKRD40, LOXL3, G3BP1, RNF157 | BRD7 | HNRNPUL1, AGR2, BHLHE40, FTH1, LAMA4, BTBD2, PAFAH1B3, PSMD11, RPLP1, SERPINB9, IRF2, BRCA1, POU2F1, PCBD1, RBFOX2, SMARCE1, BCL7C, ARID2, SMARCA4, SMARCC1, CHD7, SMARCC2, SMARCD1, TRIM24, TFAP4, BARD1, HAP1, LRIF1, NEFL, BRD2, HIST2H3C, DPF3, NUP50, TP53, EP300, GTF3C3, GTF3C5, PBRM1, MX1, HIST1H3E, REEP5, CDC5L, BCL7A, DLST |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSI2_BRD7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MSI2_BRD7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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