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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22594

FusionGeneSummary for MRS2_FAM65B

check button Fusion gene summary
Fusion gene informationFusion gene name: MRS2_FAM65B
Fusion gene ID: 22594
HgeneTgene
Gene symbol

MRS2

FAM65B

Gene ID

57380

Gene nameMRS2, magnesium transporter
SynonymsHPT|MRS2L
Cytomap

6p22.3

Type of geneprotein-coding
Descriptionmagnesium transporter MRS2 homolog, mitochondrialMRS2-like proteinMRS2-like, magnesium homeostasis factorputative magnesium transporter
Modification date20180523
UniProtAcc

Q9HD23

Ensembl transtripts involved in fusion geneENST00000274747, ENST00000543597, 
ENST00000535061, ENST00000483634, 
ENST00000378353, ENST00000378386, 
ENST00000443868, 		ENST00000259698, 
ENST00000538035, ENST00000510784, 
ENST00000378023, ENST00000540914, 
ENST00000473070, 
Fusion gene scores* DoF score6 X 6 X 5=1805 X 3 X 4=60
# samples 65
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRS2 [Title/Abstract] AND FAM65B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1II-01AMRS2chr6

24403464

+FAM65Bchr6

24876045

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000274747ENST00000259698MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000274747ENST00000538035MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000274747ENST00000510784MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000274747ENST00000378023MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000274747ENST00000540914MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-intronENST00000274747ENST00000473070MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5UTR-5UTRENST00000543597ENST00000259698MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5UTR-5UTRENST00000543597ENST00000538035MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5UTR-5UTRENST00000543597ENST00000510784MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5UTR-5UTRENST00000543597ENST00000378023MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5UTR-5UTRENST00000543597ENST00000540914MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5UTR-intronENST00000543597ENST00000473070MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000535061ENST00000259698MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000535061ENST00000538035MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000535061ENST00000510784MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000535061ENST00000378023MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000535061ENST00000540914MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-intronENST00000535061ENST00000473070MRS2chr6

24403464

+FAM65Bchr6

24876045

-
3UTR-5UTRENST00000483634ENST00000259698MRS2chr6

24403464

+FAM65Bchr6

24876045

-
3UTR-5UTRENST00000483634ENST00000538035MRS2chr6

24403464

+FAM65Bchr6

24876045

-
3UTR-5UTRENST00000483634ENST00000510784MRS2chr6

24403464

+FAM65Bchr6

24876045

-
3UTR-5UTRENST00000483634ENST00000378023MRS2chr6

24403464

+FAM65Bchr6

24876045

-
3UTR-5UTRENST00000483634ENST00000540914MRS2chr6

24403464

+FAM65Bchr6

24876045

-
3UTR-intronENST00000483634ENST00000473070MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378353ENST00000259698MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378353ENST00000538035MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378353ENST00000510784MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378353ENST00000378023MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378353ENST00000540914MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-intronENST00000378353ENST00000473070MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378386ENST00000259698MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378386ENST00000538035MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378386ENST00000510784MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378386ENST00000378023MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000378386ENST00000540914MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-intronENST00000378386ENST00000473070MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000443868ENST00000259698MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000443868ENST00000538035MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000443868ENST00000510784MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000443868ENST00000378023MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-5UTRENST00000443868ENST00000540914MRS2chr6

24403464

+FAM65Bchr6

24876045

-
5CDS-intronENST00000443868ENST00000473070MRS2chr6

24403464

+FAM65Bchr6

24876045

-

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FusionProtFeatures for MRS2_FAM65B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRS2

Q9HD23

FAM65B

Magnesium transporter that mediates the influx ofmagnesium into the mitochondrial matrix (PubMed:11401429,PubMed:18384665). Required for normal expression of themitochondrial respiratory complex I subunits (PubMed:18384665).{ECO:0000269|PubMed:11401429, ECO:0000269|PubMed:18384665}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRS2_FAM65B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRS2_FAM65B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRS2RIC3, RSRP1, CACNG4, SLC39A4, P2RY12, LUC7L, KCMF1, B3GALT2, CHST8, INTS4P2, LPAR1, UBR5, ZNF133, SYP, NOL9, TSPYL1, TBC1D15, MRPL35, ZNF747, TBC1D9, VTN, MINPP1, SPPL2B, BZW2, AURKAIP1, FEZ1, JPH4, NGEF, IPPK, HTR2C, DFNA5, SLC39A5FAM65BYWHAG, YWHAZ, RHOA, PER1, MAP2K2, RHOC, HDAC6, DYSF, MYOF, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRS2_FAM65B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRS2_FAM65B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource