FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22588

FusionGeneSummary for MRRF_KIAA0368

check button Fusion gene summary
Fusion gene informationFusion gene name: MRRF_KIAA0368
Fusion gene ID: 22588
HgeneTgene
Gene symbol

MRRF

KIAA0368

Gene ID

92399

Gene namemitochondrial ribosome recycling factor
SynonymsMRFF|MTRRF|RRF
Cytomap

9q33.2

Type of geneprotein-coding
Descriptionribosome-recycling factor, mitochondrialribosome-releasing factor, mitochondrial
Modification date20180523
UniProtAcc

Q96E11

Ensembl transtripts involved in fusion geneENST00000546115, ENST00000373730, 
ENST00000297908, ENST00000344641, 
ENST00000373723, ENST00000373729, 
ENST00000373724, ENST00000394315, 
ENST00000338205, ENST00000259335, 
ENST00000374378, ENST00000465499, 
Fusion gene scores* DoF score3 X 2 X 3=183 X 4 X 2=24
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MRRF [Title/Abstract] AND KIAA0368 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMRRF

GO:0032790

ribosome disassembly

19716793


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2754-01AMRRFchr9

125054119

+KIAA0368chr9

114206774

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000546115ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-3CDSENST00000546115ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-intronENST00000546115ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-intronENST00000546115ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-3CDSENST00000373730ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-3CDSENST00000373730ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-intronENST00000373730ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-intronENST00000373730ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000297908ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000297908ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000297908ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000297908ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000344641ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000344641ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000344641ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000344641ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000373723ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000373723ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000373723ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000373723ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000373729ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000373729ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000373729ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000373729ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-3CDSENST00000373724ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-3CDSENST00000373724ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-intronENST00000373724ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
intron-intronENST00000373724ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000394315ENST00000338205MRRFchr9

125054119

+KIAA0368chr9

114206774

-
Frame-shiftENST00000394315ENST00000259335MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000394315ENST00000374378MRRFchr9

125054119

+KIAA0368chr9

114206774

-
5CDS-intronENST00000394315ENST00000465499MRRFchr9

125054119

+KIAA0368chr9

114206774

-

Top

FusionProtFeatures for MRRF_KIAA0368


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRRF

Q96E11

KIAA0368

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MRRF_KIAA0368


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MRRF_KIAA0368


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRRFICT1, APP, CDV3, MRPL53, RPS19, NDUFA7, SARNP, TSFM, PPIF, SLIRP, PPIB, NDUFA2, RBMS1, SRPRB, SCP2, HCCS, MRRFP1, DBT, MMAB, NFS1, LYRM7, IBA57, MED4, BANP, MKNK2, ANAPC15, TUBA1C, FBXO18, ARX, SKA1, CT55KIAA0368PCM1, ARF6, PTP4A3, HNRNPA1, CLN3, SIRT7, CCDC57, PCYT1B, FBXO2, GOLGB1, SPECC1L, KIF5B, MYH7, MYH10, SYNE1, ANK2, DST, CKS1B, CPD, DNAJB9, RNF168, HNRNPM, CEP170B, ANKRD17, GAREML, MKI67, MYO10, RABEP1, RAB11FIP4, UIMC1, SF3B2, UBE2G2, UBE2Q1, VPS11, ZNF483, PSMC4, PSMD4, TUBA1A, TUBB4B, TUBB, MYO1B, KIF1B, HSPA1A, VPS36, VPS26A, TMED4, RNF217, MARCH5, KDM2B, KDM2A, FBXO44, CEP152, RCN2, PSMC2, PSMD1, PSMC6, DCTN1, DYNC1I1, PSMA6, FLOT1, FLOT2, PSMA2, SPTAN1, FN1, ADRB2, LATS2, MOB4, PSMC5, PSMD11, PSMD12, PSMD13, PSMD14, PSMD3, PSMD8, RPS23, RPS26, TSR1, TXNL1, UBR4, UCHL5, WDR26, SHFM1, AGTRAP, CMTM5, EGFR, BSG, SPACA1, GNAI2, LYPD3, RP2, HSPB1, CDKN2AIP, DDX1, DNAJB1, DNAJB4, EIF4H, FARSA, HNRNPH1, BAG1, C14orf166, CCT4, EEF1A1, EIF4E, KDM3A, LDHB, NHP2L1, PSMA5, RABIF, RAD23B, RTCB, SMCHD1, TATDN1, XPO1, MAN2B1, TIMM8B, NTRK1, ATP1A1, SLC1A5, USP9X, NOP14, SH3PXD2A, ICE1, HNRNPD, TSNAX, SLC33A1, SGTB, TMEM132A, THOC2, HIGD1A, SPICE1, PLBD2, FOXB1, FOXL1, NANOG, POU5F1, NPY2R, SLC39A9, IL13RA2, C5orf28, SLC18A1, CHRM4, APLNR, OPRM1, SLC10A7, EDNRB, TMEM199, HTR2C, MAS1, SLC2A5, EDEM3, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MRRF_KIAA0368


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MRRF_KIAA0368


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource