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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 2257

FusionGeneSummary for APPL2_NR0B1

check button Fusion gene summary
Fusion gene informationFusion gene name: APPL2_NR0B1
Fusion gene ID: 2257
HgeneTgene
Gene symbol

APPL2

NR0B1

Gene ID

55198

190

Gene nameadaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2nuclear receptor subfamily 0 group B member 1
SynonymsDIP13BAHC|AHCH|AHX|DAX-1|DAX1|DSS|GTD|HHG|NROB1|SRXY2
Cytomap

12q23.3

Xp21.2

Type of geneprotein-codingprotein-coding
DescriptionDCC-interacting protein 13-betaDIP13 betaadapter protein containing PH domain, PTB domain and leucine zipper motif 2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2nuclear receptor subfamily 0 group B member 1DSS-AHC critical region on the X chromosome protein 1nuclear hormone receptornuclear receptor DAX-1truncated nuclear receptor subfamily 0 group B member 1
Modification date2018052320180523
UniProtAcc

Q8NEU8

P51843

Ensembl transtripts involved in fusion geneENST00000258530, ENST00000539978, 
ENST00000546731, ENST00000551662, 
ENST00000549573, 		ENST00000378970, 
ENST00000378963, ENST00000453287, 
Fusion gene scores* DoF score5 X 5 X 4=1001 X 1 X 1=1
# samples 51
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: APPL2 [Title/Abstract] AND NR0B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPPL2

GO:0008283

cell proliferation

15016378

TgeneNR0B1

GO:0006694

steroid biosynthetic process

9384387

TgeneNR0B1

GO:0008104

protein localization

11875111

TgeneNR0B1

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

11875111

TgeneNR0B1

GO:0045892

negative regulation of transcription, DNA-templated

7990953|9384387


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AJ-A3BD-01AAPPL2chr12

105597481

-NR0B1chrX

30322940

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000258530ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000258530ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000258530ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
In-frameENST00000539978ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000539978ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000539978ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
intron-3CDSENST00000546731ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
intron-intronENST00000546731ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
intron-intronENST00000546731ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
In-frameENST00000551662ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000551662ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000551662ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
5UTR-3CDSENST00000549573ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
5UTR-intronENST00000549573ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5UTR-intronENST00000549573ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-

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FusionProtFeatures for APPL2_NR0B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APPL2

Q8NEU8

NR0B1

P51843

Required for the regulation of cell proliferation inresponse to extracellular signals mediated by an early endosomalcompartment. Links Rab5 to nuclear signal transduction.{ECO:0000269|PubMed:15016378}. Orphan nuclear receptor. Component of a cascade requiredfor the development of the hypothalamic-pituitary-adrenal-gonadalaxis. Acts as a coregulatory protein that inhibits thetranscriptional activity of other nuclear receptors throughheterodimeric interactions. May also have a role in thedevelopment of the embryo and in the maintenance of embryonic stemcell pluripotency (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-02205_469-5401DomainNR LBD
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-02461_466389471MotifNote=AF-2 motif
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-0213_17-5401MotifNote=LXXLL motif 1
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-02146_150-5401MotifNote=LXXLL motif 3
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-02461_466-5401MotifNote=AF-2 motif
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-0280_84-5401MotifNote=LXXLL motif 2
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-021_253-5401RegionNote=4 X 67 AA tandem repeats
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-02134_200-5401RepeatNote=3
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-021_67-5401RepeatNote=1
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-02201_253-5401RepeatNote=4%3B truncated
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287-0268_133-5401RepeatNote=2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPL2chr12:105597481chrX:30322940ENST00000258530-921277_375234665DomainPH
HgeneAPPL2chr12:105597481chrX:30322940ENST00000258530-921488_637234665DomainPID
HgeneAPPL2chr12:105597481chrX:30322940ENST00000539978-921277_375191622DomainPH
HgeneAPPL2chr12:105597481chrX:30322940ENST00000539978-921488_637191622DomainPID
HgeneAPPL2chr12:105597481chrX:30322940ENST00000551662-921277_375240671DomainPH
HgeneAPPL2chr12:105597481chrX:30322940ENST00000551662-921488_637240671DomainPID
HgeneAPPL2chr12:105597481chrX:30322940ENST00000258530-9211_428234665RegionRequired for RAB5A binding
HgeneAPPL2chr12:105597481chrX:30322940ENST00000539978-9211_428191622RegionRequired for RAB5A binding
HgeneAPPL2chr12:105597481chrX:30322940ENST00000551662-9211_428240671RegionRequired for RAB5A binding
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-02205_469389471DomainNR LBD
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-0213_17389471MotifNote=LXXLL motif 1
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-02146_150389471MotifNote=LXXLL motif 3
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-0280_84389471MotifNote=LXXLL motif 2
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-021_253389471RegionNote=4 X 67 AA tandem repeats
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-02134_200389471RepeatNote=3
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-021_67389471RepeatNote=1
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-02201_253389471RepeatNote=4%3B truncated
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970-0268_133389471RepeatNote=2


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FusionGeneSequence for APPL2_NR0B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_APPL2_ENST00000258530_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_316aa
MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFS
KVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQ
YYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQRRAGPAVREVHSGTPVGNSANTQXTHQDDAPRAPXQ

>In-frame_APPL2_ENST00000539978_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_273aa
MQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLF
GLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMD
SFLSSVADMVQRRAGPAVREVHSGTPVGNSANTQXTHQDDAPRAPXQIHRTXXYPFPAEIHQCQCHCXTVLQAHHRHSQHGXYDAGNALY

>In-frame_APPL2_ENST00000551662_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_322aa
MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFS
KVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNDVCLFLEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQ
HLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQRRAGPAVREVHSGTPVGNSANTQXTHQDDA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_APPL2_ENST00000258530_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_949nt
ATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCT
GGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAG
CTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCC
AAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAA
AAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTG
CCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAG
TACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTT
TTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCA
GTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAG
ATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCAC

>In-frame_APPL2_ENST00000539978_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_820nt
ATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTT
GCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTG
GCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTT
GGACTCGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTC
GGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAA
ATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGAC
AGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCA
GCAAATACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATT
CATCAATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTCTGTAC

>In-frame_APPL2_ENST00000551662_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_967nt
ATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCT
GGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAG
CTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCC
AAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAA
AAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGATGTCTGTTTATTTTTAGAGCATGACCTCTCAATG
GCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAG
CACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCC
CATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAA
AGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGAACACACCAGGATGACGCA
CCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGTCATTGCTGAACTGTTCTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_APPL2_ENST00000258530_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_1548nt
TTTCCCTGCCGGGCGCGCCACACTTCCTGTTGATCCGGCTCGGCCGGGGGCTGGGCCGGCGGGCAGGCGGCGGCGGCCACTGGCCAGGCG
TGGACGCGCGCGGGGCCGCCGCGGGCACGGAGTGGCCGCCGCGTCGCCTGAGCCCAGAGCCGGGGAGTGCTCTCGGCCGCCGCGTCTCCT
GCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGA
CAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCA
GCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCT
TGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAA
ACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACT
CGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAA
AGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGC
CATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTT
TTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAA
TACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCA
ATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGA
TATAAAGTCATGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATGAGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTT
TAAAATAAACTTTCTTAATATTTTTACATGCAGAGTATTTTTGTATTCAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTC
TGTTCCATAGTTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTGTACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAG
CTATTTTCACAAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAATTTGTACATATTGTTATAATAAATTTTAAGGTCTTAACTATTAA

>In-frame_APPL2_ENST00000539978_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_1628nt
TCTATTCATGGACTCCTTTTTAGTTTGCAGTGCTGCACGATGCATTGTAAAACTAGTCTGTGTGCATACACATGCGTTATTTCTGCTTAC
CTCTCATATGTGGGAAGCTGAACATTTTAGGGATTAAGAAATCTGCCTCCATTGTTGTTTAGAAGCCTCTGCTCCTTGCCTGGCACTACT
GGCTGTTGGGAATGTGAAGATAAATAAGAGTGACTACCCTTGACTGGTTCACAGTTTGTTCCAGAGACAGATAATGAGGCAACAGTTCCA
GTACAGTGTGAATCCTGCTGCGATAGGAACACAAATGCAGCTTTGAGCTCCTGCAGCTTGTACTTCTTCAGGGGCTTATTCTCTTGTCCT
ACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTAT
GGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGT
GATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCA
GACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAAT
GAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCC
GCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAG
CCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCC
GTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGA
ACACACCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGT
CATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGATATAAAGTCA
TGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATGAGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTTTAAAATAAAC
TTTCTTAATATTTTTACATGCAGAGTATTTTTGTATTCAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTCTGTTCCATAG
TTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTGTACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAGCTATTTTCAC
AAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAATTTGTACATATTGTTATAATAAATTTTAAGGTCTTAACTATTAACTTGATTGAA

>In-frame_APPL2_ENST00000551662_chr12_105597481_-_NR0B1_ENST00000378970_chrX_30322940_-_1411nt
AGTGCTCTCGGCCGCCGCGTCTCCTGCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGC
TCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATA
CCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGG
CATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTA
ATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAA
GCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGATGTCTGTTTATTTTTAGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGC
CTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGT
ACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTT
TTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAG
TGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAGA
TTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACA
GTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGATATAAAGTCATGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATG
AGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTTTAAAATAAACTTTCTTAATATTTTTACATGCAGAGTATTTTTGTATT
CAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTCTGTTCCATAGTTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTG
TACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAGCTATTTTCACAAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAAT


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FusionGenePPI for APPL2_NR0B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
APPL2APPL1, RAB22A, RUVBL2, RAB5A, RBBP7, MTA2, TINF2, POT1, FSHR, SUV39H2, ABI2, FAM65A, TPM1, RAB5C, CRADD, NTRK1, MLST8, LGALS9C, LIX1, KMT2C, MAPRE3, C17orf82, DOK3, LDHAL6B, PINK1, RBP7, ATF3, CRBN, CRLF3, LECT1, RAI2, TSC1NR0B1NRIP1, NR5A1, SREBF1, COPS2, AR, PGR, POU5F1, SNW1, ESRRA, PPARG, ESRRG, NR3C1, RNF31, RORA, NR1I3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APPL2_NR0B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNR0B1P51843DB00755TretinoinNuclear receptor subfamily 0 group B member 1small moleculeapproved|investigational|nutraceutical
TgeneNR0B1P51843DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1small moleculeapproved|investigational|vet_approved

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RelatedDiseases for APPL2_NR0B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPPL2C0033578Prostatic Neoplasms1CTD_human
HgeneAPPL2C0236969Substance-Related Disorders1CTD_human
TgeneNR0B1C0220766Congenital hypoplasia of adrenal gland13CTD_human;ORPHANET;UNIPROT