|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22560 |
FusionGeneSummary for MRPS25_VAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPS25_VAT1 | Fusion gene ID: 22560 | Hgene | Tgene | Gene symbol | MRPS25 | VAT1 | Gene ID | 64432 | 10493 |
| Gene name | mitochondrial ribosomal protein S25 | vesicle amine transport 1 | |
| Synonyms | MRP-S25|RPMS25 | VATI | |
| Cytomap | 3p25.1 | 17q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 28S ribosomal protein S25, mitochondrialS25mtmitochondrial 28S ribosomal protein S25mitochondrial small ribosomal subunit protein mS25 | synaptic vesicle membrane protein VAT-1 homologmembrane protein of cholinergic synaptic vesiclesvesicle amine transport protein 1 homolog (T. californica) | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P82663 | Q99536 | |
| Ensembl transtripts involved in fusion gene | ENST00000496484, ENST00000253686, ENST00000449354, ENST00000444840, | ENST00000355653, ENST00000587173, ENST00000420567, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 5 X 6 X 2=60 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/9*10)=2.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/60*10)=0 | |
| Context | PubMed: MRPS25 [Title/Abstract] AND VAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA642154 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000496484 | ENST00000355653 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| intron-3CDS | ENST00000496484 | ENST00000587173 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| intron-3CDS | ENST00000496484 | ENST00000420567 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000253686 | ENST00000355653 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000253686 | ENST00000587173 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000253686 | ENST00000420567 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000449354 | ENST00000355653 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000449354 | ENST00000587173 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000449354 | ENST00000420567 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000444840 | ENST00000355653 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000444840 | ENST00000587173 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
| In-frame | ENST00000444840 | ENST00000420567 | MRPS25 | chr3 | 15100875 | - | VAT1 | chr17 | 41170225 | - |
Top |
FusionProtFeatures for MRPS25_VAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPS25 | VAT1 |
| Possesses ATPase activity (By similarity). Plays a partin calcium-regulated keratinocyte activation in epidermal repairmechanisms. Has no effect on cell proliferation. Negativelyregulates mitochondrial fusion in cooperation with mitofusinproteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150,ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MRPS25_VAT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MRPS25_ENST00000253686_chr3_15100875_-_VAT1_ENST00000355653_chr17_41170225_-_2425nt AGCGTCTCCTGTGCGTCTGCGCGGGAAGTGGAACCTGGCTCTGGGGAGAAGCCGCGTGAGATCCGCGCGGGTGCTAGCTAGTCCTTTCTC GTCGCTGCTCGGCTCGCGGCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCCATCCGCCGCACCCTG CAATATCTGAGCCAGGGGAACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGGGAGCTGGGCGAGGGC GCCAGGAAGTTTGTGTTTTTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAGAACATGACGCCGTCA CCCTTCCTGCGATTCTACTTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACAGTGTTCGGAACGGCC TCGGCCAGCAAGCACGAGGCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTGGATGAGATCAAGAAG ATTTCCCCTAAAGGAGTGGACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTGAAACCCATGGGCAAA GTCGTCACCTATGGAATGGCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGGAATCAGTTCAGCGTG ACAGCTCTGCAGCTGCTGCAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAGCTGGTCAGTGGTGTG GTGGCCCGCCTCCTGGCTCTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAGGTGGCTGATGCCATG AAACAGATGCAGGAGAAGAAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAGTGGCTGTGAGACCCT AGAGACCAGCGAAGGGAGAAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAATGCTCTGCCCTCCCT CCCCCGAAGGTCTCTGTGGTGATGACCGCTCTCCCCTGCCCCTCCCCGCTTCCTGACCTCTGAAGAGGTTGGGAAGTGACCATTTGGATG TCTGGGCCCTGCCAAGGCGACAGGGAGGGTCAGAGGGAGGCCGGCTGCTTCCTGCCCCCACCCTTTCCCCGGGCCTGCTGTGCTGCTTTT GTGCCAAGGTTAGCCAGTCCCCCCTGTTGTGTTCCATGTGCTTTCACCTCTGCCTCATCTTTCCTCCCGTCCCTGCCCCGCCACCTCCCC AAAGAATTGAAACGTCAGCTCAGGATATGGGGCCAATCTCTGTGAGTCCAGCATGTACCTGTCTCTCCCTAGTGTCCCTTCAGCCTGGGC TGACCAGTGCCCGCCTCTGGGCTTGACCAGTTCCCAATCTCGTCCTCTGTCCCCAACTTCTTAAGCACAATTGGGCTTCTTCCATCTCCA GGTTTTCTGCCATTCTTAACCAAGGCTGCCTCTTCCAACAGGGCGGGAATCAGACCTACTCCCCTAGGTCACAACTCTGGGAAGGATACA GAGCCCCCACCCTTCACTGAGTTCTCTGGATTTGTTCTCAGTGCCTTAGCAACGAAAACCTGTGCTTGTGTGTGTGTGGCGGCGGGGAGG GAGGATCCTGTTTCCCACCTCCTTCTCCTCCCCTGTACTCCCCAGTGCCTTCCTTGTTCTGGTGGAGCTGGGGTTTCTCTCCTCCCCAGT CCCACAACACTGCCAAAAATCTGTGTATGTGCCATTGGGTGGGGCAGCCCCAAGCCTCCTGGGGAGGCAGGGCAAAAACAGGTGCCCTCA TCGTGGTCTGTGCCATGTCCCGTCTCTATGGTGGTTGAGGAGAAAGGCGGGGAAGCTTCCTCAGCCTTGCAGATATGTGTGGCATTTACT AGCCAGAGCTCTGAAAGGCAGTGCTGTCTGTTTCTTGTACTGGGACCAAAGTAAAAATCCAAGCACATTCCCCTTGCAGTTAGGGGAGGC CCTACTGCCTTCTCAAAGCAGAGAGGCAGCTTATCAAACTCAGCCCAAAACTCTGTTTACATGGGTGGGGAGATGGAGCAGGGAAGTACA GAGTGGGATGGTCAGGACCTGGGCCATTGCAACCAAAATGGGGACTTCCTGGGTAGGGAGGTCACTCCCTCTACTCACTGAGCTAGGATT AGGGAGGGTTATTGCCCCAACCATTGCAATGGGAGGTGGAGGGACAGGCTCAGCCTCCTCATTGTCTAAATGAGGCCTAAATGTGTGAAG >In-frame_MRPS25_ENST00000253686_chr3_15100875_-_VAT1_ENST00000587173_chr17_41170225_-_1131nt AGCGTCTCCTGTGCGTCTGCGCGGGAAGTGGAACCTGGCTCTGGGGAGAAGCCGCGTGAGATCCGCGCGGGTGCTAGCTAGTCCTTTCTC GTCGCTGCTCGGCTCGCGGCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCCATCCGCCGCACCCTG CAATATCTGAGCCAGGGGAACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGGGAGCTGGGCGAGGGC GCCAGGAAGTTTGTGTTTTTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAGAACATGACGCCGTCA CCCTTCCTGCGATTCTACTTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACAGTGTTCGGAACGGCC TCGGCCAGCAAGCACGAGGCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTGGATGAGATCAAGAAG ATTTCCCCTAAAGGAGTGGACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTGAAACCCATGGGCAAA GTCGTCACCTATGGAATGGCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGGAATCAGTTCAGCGTG ACAGCTCTGCAGCTGCTGCAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAGCTGGTCAGTGGTGTG GTGGCCCGCCTCCTGGCTCTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAGGTGGCTGATGCCATG AAACAGATGCAGGAGAAGAAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAGTGGCTGTGAGACCCT AGAGACCAGCGAAGGGAGAAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAATGCTCTGCCCTCCCT >In-frame_MRPS25_ENST00000253686_chr3_15100875_-_VAT1_ENST00000420567_chr17_41170225_-_1112nt AGCGTCTCCTGTGCGTCTGCGCGGGAAGTGGAACCTGGCTCTGGGGAGAAGCCGCGTGAGATCCGCGCGGGTGCTAGCTAGTCCTTTCTC GTCGCTGCTCGGCTCGCGGCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCCATCCGCCGCACCCTG CAATATCTGAGCCAGGGGAACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGGGAGCTGGGCGAGGGC GCCAGGAAGTTTGTGTTTTTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAGAACATGACGCCGTCA CCCTTCCTGCGATTCTACTTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACAGTGTTCGGAACGGCC TCGGCCAGCAAGCACGAGGCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTGGATGAGATCAAGAAG ATTTCCCCTAAAGGAGTGGACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTGAAACCCATGGGCAAA GTCGTCACCTATGGAATGGCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGGAATCAGTTCAGCGTG ACAGCTCTGCAGCTGCTGCAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAGCTGGTCAGTGGTGTG GTGGCCCGCCTCCTGGCTCTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAGGTGGCTGATGCCATG AAACAGATGCAGGAGAAGAAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAGTGGCTGTGAGACCCT AGAGACCAGCGAAGGGAGAAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAATGCTCTGCCCTCCCT >In-frame_MRPS25_ENST00000449354_chr3_15100875_-_VAT1_ENST00000355653_chr17_41170225_-_2350nt AGCTAGTCCTTTCTCGTCGCTGCTCGGCTCGCGGCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCC ATCCGCCGCACCCTGCAATATCTGAGCCAGGGGAACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGG GAGCTGGGCGAGGGCGCCAGGAAGTTTGTGTTTTTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAG AACATGACGCCGTCACCCTTCCTGCGATTCTACTTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACA GTGTTCGGAACGGCCTCGGCCAGCAAGCACGAGGCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTG GATGAGATCAAGAAGATTTCCCCTAAAGGAGTGGACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTG AAACCCATGGGCAAAGTCGTCACCTATGGAATGGCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGG AATCAGTTCAGCGTGACAGCTCTGCAGCTGCTGCAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAG CTGGTCAGTGGTGTGGTGGCCCGCCTCCTGGCTCTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAG GTGGCTGATGCCATGAAACAGATGCAGGAGAAGAAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAG TGGCTGTGAGACCCTAGAGACCAGCGAAGGGAGAAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAA TGCTCTGCCCTCCCTCCCCCGAAGGTCTCTGTGGTGATGACCGCTCTCCCCTGCCCCTCCCCGCTTCCTGACCTCTGAAGAGGTTGGGAA GTGACCATTTGGATGTCTGGGCCCTGCCAAGGCGACAGGGAGGGTCAGAGGGAGGCCGGCTGCTTCCTGCCCCCACCCTTTCCCCGGGCC TGCTGTGCTGCTTTTGTGCCAAGGTTAGCCAGTCCCCCCTGTTGTGTTCCATGTGCTTTCACCTCTGCCTCATCTTTCCTCCCGTCCCTG CCCCGCCACCTCCCCAAAGAATTGAAACGTCAGCTCAGGATATGGGGCCAATCTCTGTGAGTCCAGCATGTACCTGTCTCTCCCTAGTGT CCCTTCAGCCTGGGCTGACCAGTGCCCGCCTCTGGGCTTGACCAGTTCCCAATCTCGTCCTCTGTCCCCAACTTCTTAAGCACAATTGGG CTTCTTCCATCTCCAGGTTTTCTGCCATTCTTAACCAAGGCTGCCTCTTCCAACAGGGCGGGAATCAGACCTACTCCCCTAGGTCACAAC TCTGGGAAGGATACAGAGCCCCCACCCTTCACTGAGTTCTCTGGATTTGTTCTCAGTGCCTTAGCAACGAAAACCTGTGCTTGTGTGTGT GTGGCGGCGGGGAGGGAGGATCCTGTTTCCCACCTCCTTCTCCTCCCCTGTACTCCCCAGTGCCTTCCTTGTTCTGGTGGAGCTGGGGTT TCTCTCCTCCCCAGTCCCACAACACTGCCAAAAATCTGTGTATGTGCCATTGGGTGGGGCAGCCCCAAGCCTCCTGGGGAGGCAGGGCAA AAACAGGTGCCCTCATCGTGGTCTGTGCCATGTCCCGTCTCTATGGTGGTTGAGGAGAAAGGCGGGGAAGCTTCCTCAGCCTTGCAGATA TGTGTGGCATTTACTAGCCAGAGCTCTGAAAGGCAGTGCTGTCTGTTTCTTGTACTGGGACCAAAGTAAAAATCCAAGCACATTCCCCTT GCAGTTAGGGGAGGCCCTACTGCCTTCTCAAAGCAGAGAGGCAGCTTATCAAACTCAGCCCAAAACTCTGTTTACATGGGTGGGGAGATG GAGCAGGGAAGTACAGAGTGGGATGGTCAGGACCTGGGCCATTGCAACCAAAATGGGGACTTCCTGGGTAGGGAGGTCACTCCCTCTACT CACTGAGCTAGGATTAGGGAGGGTTATTGCCCCAACCATTGCAATGGGAGGTGGAGGGACAGGCTCAGCCTCCTCATTGTCTAAATGAGG CCTAAATGTGTGAAGTGCGATTTCTGCTTTTGTGTACCCCACCACCCCATTACCACAGCTGCCTTTGTGTGTTTGTGTCAATAAAAAGCC >In-frame_MRPS25_ENST00000449354_chr3_15100875_-_VAT1_ENST00000587173_chr17_41170225_-_1056nt AGCTAGTCCTTTCTCGTCGCTGCTCGGCTCGCGGCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCC ATCCGCCGCACCCTGCAATATCTGAGCCAGGGGAACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGG GAGCTGGGCGAGGGCGCCAGGAAGTTTGTGTTTTTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAG AACATGACGCCGTCACCCTTCCTGCGATTCTACTTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACA GTGTTCGGAACGGCCTCGGCCAGCAAGCACGAGGCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTG GATGAGATCAAGAAGATTTCCCCTAAAGGAGTGGACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTG AAACCCATGGGCAAAGTCGTCACCTATGGAATGGCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGG AATCAGTTCAGCGTGACAGCTCTGCAGCTGCTGCAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAG CTGGTCAGTGGTGTGGTGGCCCGCCTCCTGGCTCTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAG GTGGCTGATGCCATGAAACAGATGCAGGAGAAGAAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAG TGGCTGTGAGACCCTAGAGACCAGCGAAGGGAGAAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAA >In-frame_MRPS25_ENST00000449354_chr3_15100875_-_VAT1_ENST00000420567_chr17_41170225_-_1037nt AGCTAGTCCTTTCTCGTCGCTGCTCGGCTCGCGGCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCC ATCCGCCGCACCCTGCAATATCTGAGCCAGGGGAACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGG GAGCTGGGCGAGGGCGCCAGGAAGTTTGTGTTTTTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAG AACATGACGCCGTCACCCTTCCTGCGATTCTACTTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACA GTGTTCGGAACGGCCTCGGCCAGCAAGCACGAGGCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTG GATGAGATCAAGAAGATTTCCCCTAAAGGAGTGGACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTG AAACCCATGGGCAAAGTCGTCACCTATGGAATGGCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGG AATCAGTTCAGCGTGACAGCTCTGCAGCTGCTGCAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAG CTGGTCAGTGGTGTGGTGGCCCGCCTCCTGGCTCTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAG GTGGCTGATGCCATGAAACAGATGCAGGAGAAGAAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAG TGGCTGTGAGACCCTAGAGACCAGCGAAGGGAGAAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAA >In-frame_MRPS25_ENST00000444840_chr3_15100875_-_VAT1_ENST00000355653_chr17_41170225_-_2407nt GCGCGGGAAGTGGAACCTGGCTCTGGGGAGAAGCCGCGTGAGATCCGCGCGGGTGCTAGCTAGTCCTTTCTCGTCGCTGCTCGGCTCGCG GCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCCATCCGCCGCACCCTGCAATATCTGAGCCAGGGG AACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGGGAGCTGGGCGAGGGCGCCAGGAAGTTTGTGTTT TTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAGAACATGACGCCGTCACCCTTCCTGCGATTCTAC TTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACAGTGTTCGGAACGGCCTCGGCCAGCAAGCACGAG GCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTGGATGAGATCAAGAAGATTTCCCCTAAAGGAGTG GACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTGAAACCCATGGGCAAAGTCGTCACCTATGGAATG GCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGGAATCAGTTCAGCGTGACAGCTCTGCAGCTGCTG CAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAGCTGGTCAGTGGTGTGGTGGCCCGCCTCCTGGCT CTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAGGTGGCTGATGCCATGAAACAGATGCAGGAGAAG AAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAGTGGCTGTGAGACCCTAGAGACCAGCGAAGGGAG AAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAATGCTCTGCCCTCCCTCCCCCGAAGGTCTCTGTG GTGATGACCGCTCTCCCCTGCCCCTCCCCGCTTCCTGACCTCTGAAGAGGTTGGGAAGTGACCATTTGGATGTCTGGGCCCTGCCAAGGC GACAGGGAGGGTCAGAGGGAGGCCGGCTGCTTCCTGCCCCCACCCTTTCCCCGGGCCTGCTGTGCTGCTTTTGTGCCAAGGTTAGCCAGT CCCCCCTGTTGTGTTCCATGTGCTTTCACCTCTGCCTCATCTTTCCTCCCGTCCCTGCCCCGCCACCTCCCCAAAGAATTGAAACGTCAG CTCAGGATATGGGGCCAATCTCTGTGAGTCCAGCATGTACCTGTCTCTCCCTAGTGTCCCTTCAGCCTGGGCTGACCAGTGCCCGCCTCT GGGCTTGACCAGTTCCCAATCTCGTCCTCTGTCCCCAACTTCTTAAGCACAATTGGGCTTCTTCCATCTCCAGGTTTTCTGCCATTCTTA ACCAAGGCTGCCTCTTCCAACAGGGCGGGAATCAGACCTACTCCCCTAGGTCACAACTCTGGGAAGGATACAGAGCCCCCACCCTTCACT GAGTTCTCTGGATTTGTTCTCAGTGCCTTAGCAACGAAAACCTGTGCTTGTGTGTGTGTGGCGGCGGGGAGGGAGGATCCTGTTTCCCAC CTCCTTCTCCTCCCCTGTACTCCCCAGTGCCTTCCTTGTTCTGGTGGAGCTGGGGTTTCTCTCCTCCCCAGTCCCACAACACTGCCAAAA ATCTGTGTATGTGCCATTGGGTGGGGCAGCCCCAAGCCTCCTGGGGAGGCAGGGCAAAAACAGGTGCCCTCATCGTGGTCTGTGCCATGT CCCGTCTCTATGGTGGTTGAGGAGAAAGGCGGGGAAGCTTCCTCAGCCTTGCAGATATGTGTGGCATTTACTAGCCAGAGCTCTGAAAGG CAGTGCTGTCTGTTTCTTGTACTGGGACCAAAGTAAAAATCCAAGCACATTCCCCTTGCAGTTAGGGGAGGCCCTACTGCCTTCTCAAAG CAGAGAGGCAGCTTATCAAACTCAGCCCAAAACTCTGTTTACATGGGTGGGGAGATGGAGCAGGGAAGTACAGAGTGGGATGGTCAGGAC CTGGGCCATTGCAACCAAAATGGGGACTTCCTGGGTAGGGAGGTCACTCCCTCTACTCACTGAGCTAGGATTAGGGAGGGTTATTGCCCC AACCATTGCAATGGGAGGTGGAGGGACAGGCTCAGCCTCCTCATTGTCTAAATGAGGCCTAAATGTGTGAAGTGCGATTTCTGCTTTTGT >In-frame_MRPS25_ENST00000444840_chr3_15100875_-_VAT1_ENST00000587173_chr17_41170225_-_1113nt GCGCGGGAAGTGGAACCTGGCTCTGGGGAGAAGCCGCGTGAGATCCGCGCGGGTGCTAGCTAGTCCTTTCTCGTCGCTGCTCGGCTCGCG GCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCCATCCGCCGCACCCTGCAATATCTGAGCCAGGGG AACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGGGAGCTGGGCGAGGGCGCCAGGAAGTTTGTGTTT TTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAGAACATGACGCCGTCACCCTTCCTGCGATTCTAC TTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACAGTGTTCGGAACGGCCTCGGCCAGCAAGCACGAG GCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTGGATGAGATCAAGAAGATTTCCCCTAAAGGAGTG GACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTGAAACCCATGGGCAAAGTCGTCACCTATGGAATG GCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGGAATCAGTTCAGCGTGACAGCTCTGCAGCTGCTG CAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAGCTGGTCAGTGGTGTGGTGGCCCGCCTCCTGGCT CTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAGGTGGCTGATGCCATGAAACAGATGCAGGAGAAG AAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAGTGGCTGTGAGACCCTAGAGACCAGCGAAGGGAG AAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAATGCTCTGCCCTCCCTCCCCCGAAGGTCTCTGTG >In-frame_MRPS25_ENST00000444840_chr3_15100875_-_VAT1_ENST00000420567_chr17_41170225_-_1094nt GCGCGGGAAGTGGAACCTGGCTCTGGGGAGAAGCCGCGTGAGATCCGCGCGGGTGCTAGCTAGTCCTTTCTCGTCGCTGCTCGGCTCGCG GCCCGTGGGGTCGGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCCATCCGCCGCACCCTGCAATATCTGAGCCAGGGG AACGTGGTGTTCAAGGACTCCGTGAAGGTCATGACAGTGAATTACAACACGCATGGGGAGCTGGGCGAGGGCGCCAGGAAGTTTGTGTTT TTCAACATACCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAGAACATGACGCCGTCACCCTTCCTGCGATTCTAC TTAGGGGGTGTGGGTATGGCTGCCGTGCAGCTGTGCCGTACAGTGGAGAATGTGACAGTGTTCGGAACGGCCTCGGCCAGCAAGCACGAG GCACTGAAGGAGAATGGGGTCACACATCCCATCGACTATCACACGACTGACTACGTGGATGAGATCAAGAAGATTTCCCCTAAAGGAGTG GACATTGTCATGGACCCTCTGGGTGGGTCAGATACTGCCAAGGGCTACAACCTCCTGAAACCCATGGGCAAAGTCGTCACCTATGGAATG GCCAACCTGCTGACGGGCCCCAAACGGAACCTGATGGCCCTGGCCCGGACATGGTGGAATCAGTTCAGCGTGACAGCTCTGCAGCTGCTG CAGGCCAACCGGGCTGTGTGTGGCTTCCACCTGGGCTACCTGGATGGTGAGGTGGAGCTGGTCAGTGGTGTGGTGGCCCGCCTCCTGGCT CTGTACAACCAGGGCCACATCAAGCCCCACATTGACTCAGTCTGGCCCTTCGAGAAGGTGGCTGATGCCATGAAACAGATGCAGGAGAAG AAGAATGTGGGCAAGGTCCTCCTGGTTCCAGGGCCAGAGAAGGAGAACTAGGGCAAGTGGCTGTGAGACCCTAGAGACCAGCGAAGGGAG AAGTTGGGAAGCTACGTTCTGTTGGCCACCAGACTTGCATTTCAGCCTCTGTCATAATGCTCTGCCCTCCCTCCCCCGAAGGTCTCTGTG |
Top |
FusionGenePPI for MRPS25_VAT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRPS25 | DDX56, ICT1, MME, COPS5, CAND1, MRPS9, MRPS7, MRPS22, MRPS18B, MRPS16, MRPS35, HNRNPAB, C1QBP, GRSF1, CEP76, TP53, TUBGCP3, NOL12, TRA2A, ZC3H3, RPS8, TRMT10B, ZNF707, MRPS31, MRPS5, HNRNPU, PCNA, PCDHB15, ZFC3H1, ERBB3, CDC14B, DUSP11, MRPS34, MRPS27, MRPS15, MRPS11, KIFAP3, TRIM25 | VAT1 | PHLPP2, H2AFX, CDK2, WDR12, NRAS, ZFYVE21, WDR74, ATP4A, PARK2, MVP, S100A13, TTC1, GARS, SETSIP, NCBP1, PFKP, PLIN3, TP53, NTRK1, TMEM216, EIF2S2, DLD, SOD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MRPS25_VAT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MRPS25_VAT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|