FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22559

FusionGeneSummary for MRPS25_SEC23B

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPS25_SEC23B
Fusion gene ID: 22559
HgeneTgene
Gene symbol

MRPS25

SEC23B

Gene ID

64432

10483

Gene namemitochondrial ribosomal protein S25Sec23 homolog B, coat complex II component
SynonymsMRP-S25|RPMS25CDA-II|CDAII|CDAN2|CWS7|HEMPAS|hSec23B
Cytomap

3p25.1

20p11.23

Type of geneprotein-codingprotein-coding
Description28S ribosomal protein S25, mitochondrialS25mtmitochondrial 28S ribosomal protein S25mitochondrial small ribosomal subunit protein mS25protein transport protein Sec23BSEC23-like protein BSEC23-related protein BSec23 homolog B, COPII coat complex componenttransport protein SEC23B
Modification date2018052320180523
UniProtAcc

P82663

Q15437

Ensembl transtripts involved in fusion geneENST00000496484, ENST00000253686, 
ENST00000449354, ENST00000444840, 
ENST00000262544, ENST00000336714, 
ENST00000377475, ENST00000377465, 
ENST00000494645, 
Fusion gene scores* DoF score3 X 3 X 1=94 X 5 X 3=60
# samples 68
** MAII scorelog2(6/9*10)=2.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MRPS25 [Title/Abstract] AND SEC23B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI332698MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
ChiTaRS3.1AI399751MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
ChiTaRS3.1N22743MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
ChiTaRS3.1N34493MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000496484ENST00000262544MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000496484ENST00000336714MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000496484ENST00000377475MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000496484ENST00000377465MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-intronENST00000496484ENST00000494645MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000253686ENST00000262544MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000253686ENST00000336714MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000253686ENST00000377475MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000253686ENST00000377465MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-intronENST00000253686ENST00000494645MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000449354ENST00000262544MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000449354ENST00000336714MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000449354ENST00000377475MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000449354ENST00000377465MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-intronENST00000449354ENST00000494645MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000444840ENST00000262544MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000444840ENST00000336714MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000444840ENST00000377475MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-3CDSENST00000444840ENST00000377465MRPS25chr3

15093835

+SEC23Bchr20

18505655

-
intron-intronENST00000444840ENST00000494645MRPS25chr3

15093835

+SEC23Bchr20

18505655

-

Top

FusionProtFeatures for MRPS25_SEC23B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPS25

P82663

SEC23B

Q15437

Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex. {ECO:0000250|UniProtKB:Q15436}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MRPS25_SEC23B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MRPS25_SEC23B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MRPS25_SEC23B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MRPS25_SEC23B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSEC23BC1306589Congenital dyserythropoietic anemia, type II2ORPHANET;UNIPROT
TgeneSEC23BC0002876Congenital dyserythropoietic anemia1CTD_human
TgeneSEC23BC4225179COWDEN SYNDROME 71UNIPROT