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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22556

FusionGeneSummary for MRPS23_TRIM37

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPS23_TRIM37
Fusion gene ID: 22556
HgeneTgene
Gene symbol

MRPS23

TRIM37

Gene ID

51649

4591

Gene namemitochondrial ribosomal protein S23tripartite motif containing 37
SynonymsCGI-138|HSPC329|MRP-S23MUL|POB1|TEF3
Cytomap

17q22

17q22

Type of geneprotein-codingprotein-coding
Description28S ribosomal protein S23, mitochondrialS23mtmitochondrial small ribosomal subunit protein mS23E3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein
Modification date2018052320180522
UniProtAcc

Q9Y3D9

O94972

Ensembl transtripts involved in fusion geneENST00000313608, ENST00000578444, 
ENST00000393066, ENST00000262294, 
ENST00000376149, ENST00000393065, 
ENST00000584889, 
Fusion gene scores* DoF score4 X 2 X 3=247 X 6 X 7=294
# samples 57
** MAII scorelog2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPS23 [Title/Abstract] AND TRIM37 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM37

GO:0000122

negative regulation of transcription by RNA polymerase II

25470042

TgeneTRIM37

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

TgeneTRIM37

GO:0035518

histone H2A monoubiquitination

25470042

TgeneTRIM37

GO:0036353

histone H2A-K119 monoubiquitination

25470042

TgeneTRIM37

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

TgeneTRIM37

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300

TgeneTRIM37

GO:0051865

protein autoubiquitination

15885686

TgeneTRIM37

GO:0070842

aggresome assembly

15885686


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-BL-A0C8-01AMRPS23chr17

55926601

-TRIM37chr17

57076820

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313608ENST00000393066MRPS23chr17

55926601

-TRIM37chr17

57076820

-
Frame-shiftENST00000313608ENST00000262294MRPS23chr17

55926601

-TRIM37chr17

57076820

-
Frame-shiftENST00000313608ENST00000376149MRPS23chr17

55926601

-TRIM37chr17

57076820

-
Frame-shiftENST00000313608ENST00000393065MRPS23chr17

55926601

-TRIM37chr17

57076820

-
5CDS-intronENST00000313608ENST00000584889MRPS23chr17

55926601

-TRIM37chr17

57076820

-
Frame-shiftENST00000578444ENST00000393066MRPS23chr17

55926601

-TRIM37chr17

57076820

-
Frame-shiftENST00000578444ENST00000262294MRPS23chr17

55926601

-TRIM37chr17

57076820

-
Frame-shiftENST00000578444ENST00000376149MRPS23chr17

55926601

-TRIM37chr17

57076820

-
Frame-shiftENST00000578444ENST00000393065MRPS23chr17

55926601

-TRIM37chr17

57076820

-
5CDS-intronENST00000578444ENST00000584889MRPS23chr17

55926601

-TRIM37chr17

57076820

-

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FusionProtFeatures for MRPS23_TRIM37


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPS23

Q9Y3D9

TRIM37

O94972


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPS23_TRIM37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPS23_TRIM37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRPS23SRRM2, ICT1, CUL3, CUL1, COPS5, DCUN1D1, CAND1, MRPS27, QARS, SMURF1, FN1, VCAM1, C1QBP, ITGA4, PARK2, SMURF2, CEP250, CEP57, CEP76, TP53, TUBGCP3, TUBGCP4, VCP, USHBP1, MOV10, FBXW11, HSD17B8, TRA2A, RPL6, MRPS2, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS5, HSPB1, DAP3, MRPS22, MRPS35, MRPS9, PTCD3, AP4M1, ERBB3, ZNF746, CDC14B, MRPS34, MRPS15, E4F1, ZFC3H1, ZNF331, MRPS11, PPAN, ZNF133, ZNF324BTRIM37FAM124B, MAGEB18, TCEB3B, APEX2, FXR2, FAM107A, RIBC2, RHPN1, BYSL, ZNF655, DLGAP5, PNKP, PRC1, COPB1, KIAA0408, ZNF417, MCM10, EWSR1, MCRS1, NUDT18, PBK, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRIM37, TNFRSF1B, LTBR, NGFR, UBE2U, UBE2H, ELAVL1, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, APTX, HSP90AA1, CCDC33, CDK5RAP2, LATS2, ANKRD11, ARNT2, CEP250, DDX6, RPL9, KAT5, FAM50B, RASD1, UBASH3A, KIF9, SCNM1, ZNF329, FAM161A, SSX2IP, CWF19L2, ZMAT2, CDC20B, C17orf59, CEP192, KIAA0753, CCDC14, RPGRIP1L, CNTROB, SPICE1, CEP128, CEP63, CEP89, RPGRIP1, XPO1, HIST2H2AC, EZH2, SUZ12, BMI1, HIST3H3, ZNF816, ZNF610, ZNF550, NCAPH2, ZNF263, ZNF211, ZNF214, CDC16, TPTE2, ZNF416, BBS7, CTNNB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPS23_TRIM37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPS23_TRIM37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMRPS23C1458155Mammary Neoplasms1CTD_human
TgeneTRIM37C0524582Mulibrey Nanism4CTD_human;ORPHANET;UNIPROT
TgeneTRIM37C0016063Osteitis Fibrosa Disseminata1CTD_human
TgeneTRIM37C0019209Hepatomegaly1CTD_human;HPO
TgeneTRIM37C0376634Craniofacial Abnormalities1CTD_human