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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22527

FusionGeneSummary for MRPL52_C14orf93

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL52_C14orf93
Fusion gene ID: 22527
HgeneTgene
Gene symbol

MRPL52

C14orf93

Gene ID

122704

60686

Gene namemitochondrial ribosomal protein L52chromosome 14 open reading frame 93
Synonyms-RTFC
Cytomap

14q11.2

14q11.2

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L52, mitochondrialL52mtMRP-L52mitochondrial large ribosomal subunit protein mL52uncharacterized protein C14orf93regulator of thyroid function and cancer
Modification date2018052320180519
UniProtAcc

Q86TS9

Q9H972

Ensembl transtripts involved in fusion geneENST00000355151, ENST00000397496, 
ENST00000555345, ENST00000432849, 
ENST00000553711, ENST00000397505, 
ENST00000557221, ENST00000311892, 
ENST00000556840, ENST00000461594, 
ENST00000555536, 		ENST00000299088, 
ENST00000341470, ENST00000397379, 
ENST00000397382, ENST00000397377, 
ENST00000406429, ENST00000557513, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MRPL52 [Title/Abstract] AND C14orf93 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EE-A29V-06AMRPL52chr14

23299463

+C14orf93chr14

23468365

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355151ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000355151ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000355151ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000355151ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000355151ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000355151ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000355151ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397496ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397496ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397496ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397496ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397496ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397496ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397496ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555345ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555345ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555345ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555345ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555345ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555345ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555345ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000432849ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000432849ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000432849ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000432849ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000432849ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000432849ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000432849ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000553711ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000553711ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000553711ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000553711ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000553711ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000553711ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000553711ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397505ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397505ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397505ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397505ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397505ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397505ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000397505ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000557221ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000557221ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000557221ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000557221ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000557221ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000557221ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5CDS-5UTRENST00000557221ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000311892ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000311892ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000311892ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000311892ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000311892ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000311892ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000311892ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000556840ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000556840ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000556840ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000556840ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000556840ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000556840ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000556840ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
3UTR-5UTRENST00000461594ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
3UTR-5UTRENST00000461594ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
3UTR-5UTRENST00000461594ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
3UTR-5UTRENST00000461594ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
3UTR-5UTRENST00000461594ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
3UTR-5UTRENST00000461594ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
3UTR-5UTRENST00000461594ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555536ENST00000299088MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555536ENST00000341470MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555536ENST00000397379MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555536ENST00000397382MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555536ENST00000397377MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555536ENST00000406429MRPL52chr14

23299463

+C14orf93chr14

23468365

-
5UTR-5UTRENST00000555536ENST00000557513MRPL52chr14

23299463

+C14orf93chr14

23468365

-

Top

FusionProtFeatures for MRPL52_C14orf93


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL52

Q86TS9

C14orf93

Q9H972


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPL52_C14orf93


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MRPL52_C14orf93


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRPL52APP, MRPL51, MRPL41, MRPL55, MRPL23, MRPL32, MRPL12, MRPL13, MRPL40, MRPL3, MRPL39, MRPL38, MRPL49, TMEM177, HNRNPU, TSR1, ICT1, DDX28, RPS18, CUL7, ERLEC1, NPM1, RPS2, MRPL4, HNRNPA1, MRPS30, KIF2C, MRPL50, MRPL9, MRPL1, FGF8, RRS1, LUC7L, ZNF2, RBM3C14orf93APP, MRFAP1, MOV10, POU5F1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MRPL52_C14orf93


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPL52_C14orf93


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource