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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22518

FusionGeneSummary for MRPL48_SUGP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL48_SUGP2
Fusion gene ID: 22518
HgeneTgene
Gene symbol

MRPL48

SUGP2

Gene ID

51642

10147

Gene namemitochondrial ribosomal protein L48SURP and G-patch domain containing 2
SynonymsCGI-118|HSPC290|L48MT|MRP-L48SFRS14|SRFS14
Cytomap

11q13.4

19p13.11

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L48, mitochondrialmitochondrial large ribosomal subunit protein mL48SURP and G-patch domain-containing protein 2arginine/serine-rich-splicing factor 14splicing factor, arginine/serine-rich 14
Modification date2018052320180519
UniProtAcc

Q96GC5

Q8IX01

Ensembl transtripts involved in fusion geneENST00000310614, ENST00000535529, 
ENST00000411840, ENST00000398483, 
ENST00000542303, ENST00000314282, 
ENST00000337018, ENST00000452918, 
ENST00000601879, ENST00000600377, 
ENST00000456085, ENST00000598202, 
Fusion gene scores* DoF score11 X 4 X 8=35211 X 10 X 6=660
# samples 1711
** MAII scorelog2(17/352*10)=-1.0500406824996
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL48 [Title/Abstract] AND SUGP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-WE-A8K1-06AMRPL48chr11

73519395

+SUGP2chr19

19121151

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000310614ENST00000337018MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000310614ENST00000452918MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000310614ENST00000601879MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000310614ENST00000600377MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000310614ENST00000456085MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5CDS-intronENST00000310614ENST00000598202MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000535529ENST00000337018MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000535529ENST00000452918MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000535529ENST00000601879MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000535529ENST00000600377MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000535529ENST00000456085MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-intronENST00000535529ENST00000598202MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000411840ENST00000337018MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000411840ENST00000452918MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000411840ENST00000601879MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000411840ENST00000600377MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-3CDSENST00000411840ENST00000456085MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5UTR-intronENST00000411840ENST00000598202MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000398483ENST00000337018MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000398483ENST00000452918MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000398483ENST00000601879MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000398483ENST00000600377MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000398483ENST00000456085MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-intronENST00000398483ENST00000598202MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000542303ENST00000337018MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000542303ENST00000452918MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000542303ENST00000601879MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000542303ENST00000600377MRPL48chr11

73519395

+SUGP2chr19

19121151

-
Frame-shiftENST00000542303ENST00000456085MRPL48chr11

73519395

+SUGP2chr19

19121151

-
5CDS-intronENST00000542303ENST00000598202MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000314282ENST00000337018MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000314282ENST00000452918MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000314282ENST00000601879MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000314282ENST00000600377MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-3CDSENST00000314282ENST00000456085MRPL48chr11

73519395

+SUGP2chr19

19121151

-
intron-intronENST00000314282ENST00000598202MRPL48chr11

73519395

+SUGP2chr19

19121151

-

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FusionProtFeatures for MRPL48_SUGP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL48

Q96GC5

SUGP2

Q8IX01

May play a role in mRNA splicing. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPL48_SUGP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPL48_SUGP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRPL48OXA1L, ICT1, APP, HNRNPU, EXOSC2, LSM8, TARDBP, GRSF1, RNF2, BTRC, RPL13, NIFK, MRPL46, MRPL4, MRPL39, MRPS30, MRPL47, HNRNPA1, MRPL9, MRPL55, SDHB, CRK, RPL10, AP4M1, EXOSC4, MRPL50, CDC14B, MRPL10, MRPL41, RPL18, MRPL12, MRPL42, MRPL35SUGP2LZTR1, SIRT7, HNRNPA1, ATXN1, ATXN1L, TIMM10, SLC25A3, TIMM10B, TMEM126B, NONO, DHX9, MOV10, NDUFAF2, SOX2, HIPK4, OBSL1, CCDC8, RNF2, BMI1, EGFR, RAB3IL1, CLEC11A, B9D2, MATR3, FOXB1, FOXL1, FOXL2, FOXP3, FOXQ1, USP37, ELAVL2, NXF2, RUVBL2, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPL48_SUGP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPL48_SUGP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource