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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22502

FusionGeneSummary for MRPL42_NTN4

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL42_NTN4
Fusion gene ID: 22502
HgeneTgene
Gene symbol

MRPL42

NTN4

Gene ID

28977

59277

Gene namemitochondrial ribosomal protein L42netrin 4
SynonymsHSPC204|L31MT|L42MT|MRP-L31|MRP-L42|MRP-S32|MRPL31|MRPS32|PTD007|RPML31|S32MTPRO3091
Cytomap

12q22

12q22

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L42, mitochondrial28S ribosomal protein S32, mitochondrial39S ribosomal protein L31, mitochondrialmitochondrial large ribosomal subunit protein mL42netrin-4beta-netrinhepar-derived netrin-like protein
Modification date2018052320180519
UniProtAcc

Q9Y6G3

Q9HB63

Ensembl transtripts involved in fusion geneENST00000549982, ENST00000361630, 
ENST00000552217, ENST00000393128, 
ENST00000547098, ENST00000548545, 
ENST00000552938, 
ENST00000343702, 
ENST00000344911, ENST00000538383, 
ENST00000553059, ENST00000552603, 
Fusion gene scores* DoF score5 X 4 X 4=806 X 5 X 3=90
# samples 56
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL42 [Title/Abstract] AND NTN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3M1-01AMRPL42chr12

93861330

+NTN4chr12

96131922

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000549982ENST00000343702MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000549982ENST00000344911MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000549982ENST00000538383MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000549982ENST00000553059MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-5UTRENST00000549982ENST00000552603MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000361630ENST00000343702MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000361630ENST00000344911MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000361630ENST00000538383MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000361630ENST00000553059MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-5UTRENST00000361630ENST00000552603MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000552217ENST00000343702MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000552217ENST00000344911MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000552217ENST00000538383MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000552217ENST00000553059MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-5UTRENST00000552217ENST00000552603MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000393128ENST00000343702MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000393128ENST00000344911MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000393128ENST00000538383MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000393128ENST00000553059MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-5UTRENST00000393128ENST00000552603MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000547098ENST00000343702MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000547098ENST00000344911MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000547098ENST00000538383MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-3CDSENST00000547098ENST00000553059MRPL42chr12

93861330

+NTN4chr12

96131922

-
5UTR-5UTRENST00000547098ENST00000552603MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000548545ENST00000343702MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000548545ENST00000344911MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000548545ENST00000538383MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000548545ENST00000553059MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-5UTRENST00000548545ENST00000552603MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000552938ENST00000343702MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000552938ENST00000344911MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000552938ENST00000538383MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-3CDSENST00000552938ENST00000553059MRPL42chr12

93861330

+NTN4chr12

96131922

-
intron-5UTRENST00000552938ENST00000552603MRPL42chr12

93861330

+NTN4chr12

96131922

-

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FusionProtFeatures for MRPL42_NTN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL42

Q9Y6G3

NTN4

Q9HB63


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPL42_NTN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPL42_NTN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRPL42IKBKAP, EEF1A1, MRPL40, MRPL32, MRPL13, MRPS9, MRPL23, MRPL3, MRPS26, MRPL41, MRPL12, MRPL37, MRPL44, MRPS35, MRPS28, ILF3, HNRNPR, HNRNPU, CYB5B, ICT1, DDX28, FUBP1, HNRNPC, ATP5F1, DLD, MRPL43, RPL13, RPL6, MRPL4, MRPL39, CASQ2, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, MRPL10, MRPL51, MRPL21, GATC, MRPL45, GADD45GIP1, MRPL11, MRPL38, MRPL27, MRPL30, MRPL49, MRPL28, MRPL55, MRPL24, MRPL20, MRPL35, SIRT3, MRPL22, MRPL57, MRPL2, MALSU1, MRPL17, RNMTL1, MRPL33, MRPL16, MRPS18A, MRPL15, MRPL19, MRPL48, NGRN, MRPL34, MRPL18, MRPL46, ACAA1NTN4PLSCR1, ADAMTSL4, CDKN1A, KRTAP5-9, ENO1, SHMT2, MOV10, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPL42_NTN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPL42_NTN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource