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Fusion gene ID: 22473 |
FusionGeneSummary for MRPL21_SHANK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPL21_SHANK2 | Fusion gene ID: 22473 | Hgene | Tgene | Gene symbol | MRPL21 | SHANK2 | Gene ID | 219927 | 22941 |
| Gene name | mitochondrial ribosomal protein L21 | SH3 and multiple ankyrin repeat domains 2 | |
| Synonyms | L21mt|MRP-L21 | AUTS17|CORTBP1|CTTNBP1|ProSAP1|SHANK|SPANK-3 | |
| Cytomap | 11q13.3 | 11q13.3-q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 39S ribosomal protein L21, mitochondrialmitochondrial large ribosomal subunit protein bL21m | SH3 and multiple ankyrin repeat domains protein 2GKAP/SAPAP interacting proteincortactin SH3 domain-binding proteincortactin-binding protein 1proline-rich synapse associated protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z2W9 | Q9UPX8 | |
| Ensembl transtripts involved in fusion gene | ENST00000450904, ENST00000362034, ENST00000567045, | ENST00000449833, ENST00000409161, ENST00000423696, ENST00000338508, ENST00000409530, ENST00000449116, ENST00000357171, ENST00000468619, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 27 X 15 X 8=3240 |
| # samples | 8 | 30 | |
| ** MAII score | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(30/3240*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MRPL21 [Title/Abstract] AND SHANK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-F7-7848-01A | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000450904 | ENST00000449833 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| In-frame | ENST00000450904 | ENST00000409161 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| Frame-shift | ENST00000450904 | ENST00000423696 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| Frame-shift | ENST00000450904 | ENST00000338508 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000450904 | ENST00000409530 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000450904 | ENST00000449116 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000450904 | ENST00000357171 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000450904 | ENST00000468619 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| Frame-shift | ENST00000362034 | ENST00000449833 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| Frame-shift | ENST00000362034 | ENST00000409161 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| In-frame | ENST00000362034 | ENST00000423696 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| In-frame | ENST00000362034 | ENST00000338508 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000362034 | ENST00000409530 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000362034 | ENST00000449116 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000362034 | ENST00000357171 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| 5CDS-intron | ENST00000362034 | ENST00000468619 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-3CDS | ENST00000567045 | ENST00000449833 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-3CDS | ENST00000567045 | ENST00000409161 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-3CDS | ENST00000567045 | ENST00000423696 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-3CDS | ENST00000567045 | ENST00000338508 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-intron | ENST00000567045 | ENST00000409530 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-intron | ENST00000567045 | ENST00000449116 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-intron | ENST00000567045 | ENST00000357171 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
| intron-intron | ENST00000567045 | ENST00000468619 | MRPL21 | chr11 | 68660358 | - | SHANK2 | chr11 | 70319544 | - |
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FusionProtFeatures for MRPL21_SHANK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPL21 | SHANK2 |
| Seems to be an adapter protein in the postsynapticdensity (PSD) of excitatory synapses that interconnects receptorsof the postsynaptic membrane including NMDA-type and metabotropicglutamate receptors, and the actin-based cytoskeleton. May play arole in the structural and functional organization of thedendritic spine and synaptic junction. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000423696 | - | 14 | 16 | 1407_1470 | 1280 | 1471 | Domain | SAM |
| Tgene | >SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000449833 | - | 8 | 10 | 1407_1470 | 1064 | 1255 | Domain | SAM |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000423696 | - | 14 | 16 | 509_535 | 1280 | 1471 | Compositional bias | Note=Pro-rich |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000449833 | - | 8 | 10 | 509_535 | 1064 | 1255 | Compositional bias | Note=Pro-rich |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000423696 | - | 14 | 16 | 147_206 | 1280 | 1471 | Domain | SH3 |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000423696 | - | 14 | 16 | 247_341 | 1280 | 1471 | Domain | PDZ |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000449833 | - | 8 | 10 | 147_206 | 1064 | 1255 | Domain | SH3 |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000449833 | - | 8 | 10 | 247_341 | 1064 | 1255 | Domain | PDZ |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000423696 | - | 14 | 16 | 948_954 | 1280 | 1471 | Motif | SH3-binding |
| Tgene | SHANK2 | chr11:68660358 | chr11:70319544 | ENST00000449833 | - | 8 | 10 | 948_954 | 1064 | 1255 | Motif | SH3-binding |
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FusionGeneSequence for MRPL21_SHANK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MRPL21_ENST00000450904_chr11_68660358_-_SHANK2_ENST00000449833_chr11_70319544_-_190aa KPGDHEHHLRYTEHDGHLHCSPRHLPAHHPAEPAPRLXKQDLRNKTCPKPCGLANRDEQRDPARPPVCCHRLSFSRSLRCLXPSKPAPFW GSIWLEPSGTQXVAIPLDTATANLKXAFYNXTCPPVDXTRCGRLAGKSKLGXTXRGLHGQXDRWQSLTKPAEGGPHRSWGNSSRAQNEHR >In-frame_MRPL21_ENST00000450904_chr11_68660358_-_SHANK2_ENST00000409161_chr11_70319544_-_190aa KPGDHEHHLRYTEHDGHLHCSPRHLPAHHPAEPAPRLXKQDLRNKTCPKPCGLANRDEQRDPARPPVCCHRLSFSRSLRCLXPSKPAPFW GSIWLEPSGTQXVAIPLDTATANLKXAFYNXTCPPVDXTRCGRLAGKSKLGXTXRGLHGQXDRWQSLTKPAEGGPHRSWGNSSRAQNEHR >In-frame_MRPL21_ENST00000362034_chr11_68660358_-_SHANK2_ENST00000423696_chr11_70319544_-_374aa MAASSLTVTLGRLASACSHSILRPSGPGAASLWSASRRFNSQSTSYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTG QYGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKVLLVGADNFTLLGKPLLGKDLVRVEATVIEKTESWPRIIMRFRKRKNF KKKRKARRSXAPSQVHGARRSPSLFAPAPPSPSPCRAGPPTMKAGPQEQDVPQALWSRQQRXTKRPCPPPCLLPPPLLLPLSQMSLAFQA SPLLGIYLAXTQRDAVGRHPPRYCNSQSQISLLQLNLSTCGLNQMWPIGWKVXTWVNIKRPSWTMRSMAVTYQTCRRRTSSILGXLESGT >In-frame_MRPL21_ENST00000362034_chr11_68660358_-_SHANK2_ENST00000338508_chr11_70319544_-_374aa MAASSLTVTLGRLASACSHSILRPSGPGAASLWSASRRFNSQSTSYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTG QYGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKVLLVGADNFTLLGKPLLGKDLVRVEATVIEKTESWPRIIMRFRKRKNF KKKRKARRSXAPSQVHGARRSPSLFAPAPPSPSPCRAGPPTMKAGPQEQDVPQALWSRQQRXTKRPCPPPCLLPPPLLLPLSQMSLAFQA SPLLGIYLAXTQRDAVGRHPPRYCNSQSQISLLQLNLSTCGLNQMWPIGWKVXTWVNIKRPSWTMRSMAVTYQTCRRRTSSILGXLESGT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MRPL21_ENST00000450904_chr11_68660358_-_SHANK2_ENST00000449833_chr11_70319544_-_571nt AAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACCCT GCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAAGA GACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCTGG GGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACAAC TAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGACAA TGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATAGA >In-frame_MRPL21_ENST00000450904_chr11_68660358_-_SHANK2_ENST00000409161_chr11_70319544_-_571nt AAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACCCT GCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAAGA GACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCTGG GGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACAAC TAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGACAA TGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATAGA >In-frame_MRPL21_ENST00000362034_chr11_68660358_-_SHANK2_ENST00000423696_chr11_70319544_-_1124nt ATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCC TCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAGTTCACCACCT TGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGG CAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTA GACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGTCCTGCTGGTTGGGGCAGACAACTTCACGCTGCTTGGCAAGCCACTCCTCGGA AAGGATCTTGTTCGAGTAGAAGCCACAGTCATTGAAAAGACAGAATCATGGCCAAGAATCATTATGAGATTCAGGAAAAGGAAAAACTTC AAGAAGAAAAGAAAAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCC AGCCCATCACCCTGCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAG AGATGAACAAAGAGACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCC AGCCCCCTTCTGGGGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATA AGCCTTTTACAACTAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGG CCTTCATGGACAATGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACA >In-frame_MRPL21_ENST00000362034_chr11_68660358_-_SHANK2_ENST00000338508_chr11_70319544_-_1124nt ATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCC TCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAGTTCACCACCT TGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGG CAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTA GACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGTCCTGCTGGTTGGGGCAGACAACTTCACGCTGCTTGGCAAGCCACTCCTCGGA AAGGATCTTGTTCGAGTAGAAGCCACAGTCATTGAAAAGACAGAATCATGGCCAAGAATCATTATGAGATTCAGGAAAAGGAAAAACTTC AAGAAGAAAAGAAAAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCC AGCCCATCACCCTGCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAG AGATGAACAAAGAGACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCC AGCCCCCTTCTGGGGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATA AGCCTTTTACAACTAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGG CCTTCATGGACAATGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MRPL21_ENST00000450904_chr11_68660358_-_SHANK2_ENST00000449833_chr11_70319544_-_6126nt ACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGG TTCAATTCACAGAGCACTTCATATCTACCAGGGTAATATCAAAATATATGTTCCTAAAACATCCCTGAGTTCACCACCTTGGCCAGAAGT TGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGGCAGTATGGCAG GCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTAGACCTTGCGTG TGGAGAGAGAATTCGACTGGAGAAGGTCCTGCTGGTTGGGGCAGACAACTTCACGCTGCTTGGCAAGCCACTCCTCGGAAAGGATCTTGT TCGAGTAGAAGCCACAGTCATTGAAAAGACAGAATCATGGCCAAGAATCATTATGAGATTCAGGAAAAGGAAAAACTTCAAGAAGAAAAG AAAAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACC CTGCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAA GAGACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCT GGGGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACA ACTAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGAC AATGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATA GAAAGGGCTTTGAAACAGCTGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTTATAAGTAGAGATGGGCTCGTG CTGAAACATCTGAATGCCAAGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTACCCAAAGAAATACTGAGTTGTG TCCACAACATGGCTGGGTCTTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACACATGGGACAAGGGGAGGGAGTT TTTCTAACATGGAAAAAGATTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGAGAGGCTCCCCGTCAATTTTGC ACGGGATCCTAGCTCTTGTAGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGCTTTCCGGGCAGCTCTCACCAC CCCAGGCCCCGGCATGAGGCCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCCCCTCTTTCTCCTGCACTTGGC TTGCAGTGAGATGCTCCCAGATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTTTTCCTACACAGATTCTTTTCC CCATCTCCTCCTGTGGTTTGCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGGATGGGATCGTGCCCAGCTTTG CTTAGCTTTCTTTATTTCTGCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAGTTAGTCAAAGCACAAAGTCAC GATTCCACAATGGAGGGGAGACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCTCCAGGACAAGAGCAGTTGTCT GCCATGAGCACCCATCCAGGATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGATGTCTTGAGCTCTGCAAAGAT CAGAGCAGGTGAGCATCCACTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGGCTGCCAGTGAGACAGCGTCTC CTCTGGGAGCTGGGCGGGCACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGACAGTCCTTTTGCTCTCGGAGG CCAGGGAAGATGGTACTTAGAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTCTTAACAGTACAACAGCTTCTT TGAGGACCCAGTGGGTATGGAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCAGAGTGAAAGCAGAGGCGTGAG GAGAGGAAAGCAGGGAGGTCTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGCCCCTTTCTTTCCCCGGAGTCC CTCCACCCCATAACAATACCTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACACAGTCAGGCTTCCAGCACATTC TCCCCCATTTGGAGGATACTCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCCATCTCTAATTATAAAACATGG TTTTGTTTTTTTTTTTTCCTTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATTTAGCAATTTAAAATCTTTCTT TACTGCAAGTTTAAATAGTTGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGTCTACTAGGCAGCCTTTGTGCC ACTTCAGTGCTAGAAAGTTAAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAATTATAAAAGTATGACCTTTTTA AATCAACCTTATTTGGATGCATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTCGTCATTGAAGGACAATTTCTT CAAAGTGGTTACAATTCATAATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACGCGCTTTTCCAGTCACACACCC CTGATGTTGGAACCAAGTTTTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAAATGATCCAATCCAACTTGAAG TCAATTGAATATTAAGGCGCTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATTACTCTAGATAAATTTCAAGAC AGGATACTACAGGTGGCCTGCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCATTAATTTGTCTTCCATTTGATG ATACCGCAAAATTCCGTGAGTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACCTCTGTGCTCAGTGCCAGGCAA AACACTAGCTCAAAGGAGAGTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGGTTTGTTGAACTTTGGCAGCCA GTTGGTGAGGGCCAGATGTTATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCAAGCTGGCTGCAAGACTAAAGA GCTGATAACATAGTTTATTTTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACTGACCAACAAATAAACACATGT TGCCAAGATGAATCGGTCTCTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAAATCACCACCCACTGTTCTCCC CCTTTGGGACATGTTAGGACGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTGCTCATCTAAAGATCATGTTGA TATTATTCCAGGTTTTAAGATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCTAGTTTCTGTAATATTGTGTAT ACAAAACCCAAATCTCTCAAAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCGCACATTTTAAGTTAATTCACA TAATATAAAAATTACTCAATGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGTGATACTTTAGTTAATAAAATG GTAAATTTTTTTCTCAGTTATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTGTGGGCCACAATATTGATTTTC CCATTAACAATTTTTTTTTGTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGTGTTCGCATTATCTATGTTGCT GTTACTTTTGTGCTTTTATTCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTTCTCCCAATCCTTAAATCTCTT GTATGGCAACCAAAATTACTGTAAAAAAATAAATATACTATTGCACTAAGGTTGTGGTTCTGATTGCAAACAAACAGTGAACACTGTCTG AATTAAACAAAAAGCTGCCCGACTTGCAATCTAATGTAGATTATCTCAGGCATTGTGGCCAGCTCTGCCTCTCTAAAACTGACCAGAAAA ATCTCTCTCATCGAGTAAACAGGCTCCTGTCACTGAGCTAATCTGCCTTGGTTCCATTTCCTTATTCTCAATTTATCAATGGATACGTGC ATGTTATTTCAGAATTATGCAAAACGTCAAAATCTGCTTCTGTGACCGCTGCTATAGGCGTGGAGCTGAGGCTCGGCTTTTCCTTTTGTT CTGGGTGGAAGCAGCGGTGCCGCGGAGGGCCAGCCAGATCCGGACCCTTCCCTTAGGGTCCAGTCTCCCCACACCCCAGCAGGGTGTCTT CTAGCCATAAGGCCAAGGGAGTGGCAGAACTGGGCCGCCTCTCTGGTTGACAAGCAAACCACATGCTAAGGCTTGGAGCAAGAGAGAATT TGTGTCTATTGGCAAAGAACTAAGCCAGGAAGACATGGGCCATCCCTCCGCTTTAGGGAAGCATATTTTAAACCTAAACGTTGAACTTCT TCTTTGGCCTCACCAGTGAAAACTTGTTGTCTTTAGTTCCTAAAGTTTCTTCTACTTTGGCACATTCCCCAGTTGAGCAGCAGCCTCTAT GCTTCCACGTTCAGGAAAAATTCCAGTCCTCATATCTTTTGTAGTTCACCCTCAAGCTCTCCCGCTTCACCATCCAATAGTTTCTCCCAA ACCTTGGCACCCCCCTAGACTTTGCTTCCAATGGTTTCTTCCAGACCACTTTTCCTAGATGAATATATTCGTTTACCTTACTAGGAAAAT TATTGGAAGATTTTTTCTTTTACTTGAAATTGGAGGCATTTTAATAACTGGCGAACTGGAATGTGTTTCTGTATTTGTAGACAACCATGA ACCCATGCAAGTAGGTGAACATTCCACAGTGGCTGGGTGACCACAGCAGCTGCATGCAGACAGGACTGCCCGTGCTTTGTGGGGAATCAG AGAATTTCCAAACTTGTTTCTCAGACTTCCGCAGATCTCATCACTTTGATTTCTAATCCATGCTGTATTGGTGATTTTGTTTATCGTTCC TGTAACTTGTTCTACATTCCACAGTCTTTACCGTTTTATGTTCAAAATTACAACAATCCCTGTCCATTGATTCCACTCTGGAACTCTTTG TTCATGCCAATTTTGAAATTTTAATACGAGCCTTCAAATAAACACAGAAAAGAAAAAAAAAAAGGAAAAAAAATAAAGTGTGTGCCTTGG GTGTTTTGAACCTGATCTGCATAAAACCATATTGTATTCAAATGCTGTATCTTTCATGAAAGGATAAATATATCTTCAATGTATTAATGT AGCTGATAAAATAGTTATAGTGCCTTGTTTTCTGAACTGAGAAGCCCATATCAATGCACAACGTAAAGAAAGGACGGTTCGAGCTATGAA ATGTTGAGGACACCTACACGTGATTCTGGAGCCTTTCTCATCATAAGACTGTGGAAAATACACAGTCGTTTAAGTTAAAAATAAAAAGTA >In-frame_MRPL21_ENST00000450904_chr11_68660358_-_SHANK2_ENST00000409161_chr11_70319544_-_4549nt ACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGG TTCAATTCACAGAGCACTTCATATCTACCAGGGTAATATCAAAATATATGTTCCTAAAACATCCCTGAGTTCACCACCTTGGCCAGAAGT TGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGGCAGTATGGCAG GCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTAGACCTTGCGTG TGGAGAGAGAATTCGACTGGAGAAGGTCCTGCTGGTTGGGGCAGACAACTTCACGCTGCTTGGCAAGCCACTCCTCGGAAAGGATCTTGT TCGAGTAGAAGCCACAGTCATTGAAAAGACAGAATCATGGCCAAGAATCATTATGAGATTCAGGAAAAGGAAAAACTTCAAGAAGAAAAG AAAAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACC CTGCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAA GAGACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCT GGGGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACA ACTAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGAC AATGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATA GAAAGGGCTTTGAAACAGCTGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTTATAAGTAGAGATGGGCTCGTG CTGAAACATCTGAATGCCAAGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTACCCAAAGAAATACTGAGTTGTG TCCACAACATGGCTGGGTCTTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACACATGGGACAAGGGGAGGGAGTT TTTCTAACATGGAAAAAGATTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGAGAGGCTCCCCGTCAATTTTGC ACGGGATCCTAGCTCTTGTAGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGCTTTCCGGGCAGCTCTCACCAC CCCAGGCCCCGGCATGAGGCCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCCCCTCTTTCTCCTGCACTTGGC TTGCAGTGAGATGCTCCCAGATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTTTTCCTACACAGATTCTTTTCC CCATCTCCTCCTGTGGTTTGCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGGATGGGATCGTGCCCAGCTTTG CTTAGCTTTCTTTATTTCTGCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAGTTAGTCAAAGCACAAAGTCAC GATTCCACAATGGAGGGGAGACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCTCCAGGACAAGAGCAGTTGTCT GCCATGAGCACCCATCCAGGATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGATGTCTTGAGCTCTGCAAAGAT CAGAGCAGGTGAGCATCCACTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGGCTGCCAGTGAGACAGCGTCTC CTCTGGGAGCTGGGCGGGCACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGACAGTCCTTTTGCTCTCGGAGG CCAGGGAAGATGGTACTTAGAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTCTTAACAGTACAACAGCTTCTT TGAGGACCCAGTGGGTATGGAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCAGAGTGAAAGCAGAGGCGTGAG GAGAGGAAAGCAGGGAGGTCTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGCCCCTTTCTTTCCCCGGAGTCC CTCCACCCCATAACAATACCTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACACAGTCAGGCTTCCAGCACATTC TCCCCCATTTGGAGGATACTCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCCATCTCTAATTATAAAACATGG TTTTGTTTTTTTTTTTTCCTTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATTTAGCAATTTAAAATCTTTCTT TACTGCAAGTTTAAATAGTTGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGTCTACTAGGCAGCCTTTGTGCC ACTTCAGTGCTAGAAAGTTAAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAATTATAAAAGTATGACCTTTTTA AATCAACCTTATTTGGATGCATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTCGTCATTGAAGGACAATTTCTT CAAAGTGGTTACAATTCATAATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACGCGCTTTTCCAGTCACACACCC CTGATGTTGGAACCAAGTTTTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAAATGATCCAATCCAACTTGAAG TCAATTGAATATTAAGGCGCTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATTACTCTAGATAAATTTCAAGAC AGGATACTACAGGTGGCCTGCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCATTAATTTGTCTTCCATTTGATG ATACCGCAAAATTCCGTGAGTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACCTCTGTGCTCAGTGCCAGGCAA AACACTAGCTCAAAGGAGAGTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGGTTTGTTGAACTTTGGCAGCCA GTTGGTGAGGGCCAGATGTTATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCAAGCTGGCTGCAAGACTAAAGA GCTGATAACATAGTTTATTTTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACTGACCAACAAATAAACACATGT TGCCAAGATGAATCGGTCTCTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAAATCACCACCCACTGTTCTCCC CCTTTGGGACATGTTAGGACGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTGCTCATCTAAAGATCATGTTGA TATTATTCCAGGTTTTAAGATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCTAGTTTCTGTAATATTGTGTAT ACAAAACCCAAATCTCTCAAAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCGCACATTTTAAGTTAATTCACA TAATATAAAAATTACTCAATGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGTGATACTTTAGTTAATAAAATG GTAAATTTTTTTCTCAGTTATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTGTGGGCCACAATATTGATTTTC CCATTAACAATTTTTTTTTGTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGTGTTCGCATTATCTATGTTGCT GTTACTTTTGTGCTTTTATTCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTTCTCCCAATCCTTAAATCTCTT >In-frame_MRPL21_ENST00000362034_chr11_68660358_-_SHANK2_ENST00000423696_chr11_70319544_-_4568nt GGCTGCGGCCATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCC CGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAG TTCACCACCTTGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGAT CGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGG AAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGTCCTGCTGGTTGGGGCAGACAACTTCACGCTGCTTGGCAAGCC ACTCCTCGGAAAGGATCTTGTTCGAGTAGAAGCCACAGTCATTGAAAAGACAGAATCATGGCCAAGAATCATTATGAGATTCAGGAAAAG GAAAAACTTCAAGAAGAAAAGAAAAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCC GGCACCTCCCAGCCCATCACCCTGCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTC TCGCCAACAGAGATGAACAAAGAGACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGC CTTCCAAGCCAGCCCCCTTCTGGGGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCA ATCTCAAATAAGCCTTTTACAACTAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAA CATAAAGAGGCCTTCATGGACAATGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGA GTCGGGCACAGAATGAACATAGAAAGGGCTTTGAAACAGCTGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTT ATAAGTAGAGATGGGCTCGTGCTGAAACATCTGAATGCCAAGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTAC CCAAAGAAATACTGAGTTGTGTCCACAACATGGCTGGGTCTTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACAC ATGGGACAAGGGGAGGGAGTTTTTCTAACATGGAAAAAGATTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGA GAGGCTCCCCGTCAATTTTGCACGGGATCCTAGCTCTTGTAGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGC TTTCCGGGCAGCTCTCACCACCCCAGGCCCCGGCATGAGGCCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCC CCTCTTTCTCCTGCACTTGGCTTGCAGTGAGATGCTCCCAGATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTT TTCCTACACAGATTCTTTTCCCCATCTCCTCCTGTGGTTTGCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGG ATGGGATCGTGCCCAGCTTTGCTTAGCTTTCTTTATTTCTGCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAG TTAGTCAAAGCACAAAGTCACGATTCCACAATGGAGGGGAGACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCT CCAGGACAAGAGCAGTTGTCTGCCATGAGCACCCATCCAGGATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGA TGTCTTGAGCTCTGCAAAGATCAGAGCAGGTGAGCATCCACTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGG CTGCCAGTGAGACAGCGTCTCCTCTGGGAGCTGGGCGGGCACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGA CAGTCCTTTTGCTCTCGGAGGCCAGGGAAGATGGTACTTAGAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTC TTAACAGTACAACAGCTTCTTTGAGGACCCAGTGGGTATGGAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCA GAGTGAAAGCAGAGGCGTGAGGAGAGGAAAGCAGGGAGGTCTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGC CCCTTTCTTTCCCCGGAGTCCCTCCACCCCATAACAATACCTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACAC AGTCAGGCTTCCAGCACATTCTCCCCCATTTGGAGGATACTCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCC ATCTCTAATTATAAAACATGGTTTTGTTTTTTTTTTTTCCTTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATT TAGCAATTTAAAATCTTTCTTTACTGCAAGTTTAAATAGTTGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGT CTACTAGGCAGCCTTTGTGCCACTTCAGTGCTAGAAAGTTAAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAAT TATAAAAGTATGACCTTTTTAAATCAACCTTATTTGGATGCATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTC GTCATTGAAGGACAATTTCTTCAAAGTGGTTACAATTCATAATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACG CGCTTTTCCAGTCACACACCCCTGATGTTGGAACCAAGTTTTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAA ATGATCCAATCCAACTTGAAGTCAATTGAATATTAAGGCGCTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATT ACTCTAGATAAATTTCAAGACAGGATACTACAGGTGGCCTGCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCAT TAATTTGTCTTCCATTTGATGATACCGCAAAATTCCGTGAGTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACC TCTGTGCTCAGTGCCAGGCAAAACACTAGCTCAAAGGAGAGTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGG TTTGTTGAACTTTGGCAGCCAGTTGGTGAGGGCCAGATGTTATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCA AGCTGGCTGCAAGACTAAAGAGCTGATAACATAGTTTATTTTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACT GACCAACAAATAAACACATGTTGCCAAGATGAATCGGTCTCTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAA ATCACCACCCACTGTTCTCCCCCTTTGGGACATGTTAGGACGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTG CTCATCTAAAGATCATGTTGATATTATTCCAGGTTTTAAGATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCT AGTTTCTGTAATATTGTGTATACAAAACCCAAATCTCTCAAAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCG CACATTTTAAGTTAATTCACATAATATAAAAATTACTCAATGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGT GATACTTTAGTTAATAAAATGGTAAATTTTTTTCTCAGTTATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTG TGGGCCACAATATTGATTTTCCCATTAACAATTTTTTTTTGTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGT GTTCGCATTATCTATGTTGCTGTTACTTTTGTGCTTTTATTCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTT >In-frame_MRPL21_ENST00000362034_chr11_68660358_-_SHANK2_ENST00000338508_chr11_70319544_-_4568nt GGCTGCGGCCATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCC CGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAG TTCACCACCTTGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGAT CGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGG AAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGTCCTGCTGGTTGGGGCAGACAACTTCACGCTGCTTGGCAAGCC ACTCCTCGGAAAGGATCTTGTTCGAGTAGAAGCCACAGTCATTGAAAAGACAGAATCATGGCCAAGAATCATTATGAGATTCAGGAAAAG GAAAAACTTCAAGAAGAAAAGAAAAGCCCGGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCC GGCACCTCCCAGCCCATCACCCTGCAGAGCCGGCCCCCCGACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTC TCGCCAACAGAGATGAACAAAGAGACCCTGCCCGCCCCCCTGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGC CTTCCAAGCCAGCCCCCTTCTGGGGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCA ATCTCAAATAAGCCTTTTACAACTAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAA CATAAAGAGGCCTTCATGGACAATGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGA GTCGGGCACAGAATGAACATAGAAAGGGCTTTGAAACAGCTGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTT ATAAGTAGAGATGGGCTCGTGCTGAAACATCTGAATGCCAAGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTAC CCAAAGAAATACTGAGTTGTGTCCACAACATGGCTGGGTCTTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACAC ATGGGACAAGGGGAGGGAGTTTTTCTAACATGGAAAAAGATTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGA GAGGCTCCCCGTCAATTTTGCACGGGATCCTAGCTCTTGTAGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGC TTTCCGGGCAGCTCTCACCACCCCAGGCCCCGGCATGAGGCCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCC CCTCTTTCTCCTGCACTTGGCTTGCAGTGAGATGCTCCCAGATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTT TTCCTACACAGATTCTTTTCCCCATCTCCTCCTGTGGTTTGCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGG ATGGGATCGTGCCCAGCTTTGCTTAGCTTTCTTTATTTCTGCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAG TTAGTCAAAGCACAAAGTCACGATTCCACAATGGAGGGGAGACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCT CCAGGACAAGAGCAGTTGTCTGCCATGAGCACCCATCCAGGATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGA TGTCTTGAGCTCTGCAAAGATCAGAGCAGGTGAGCATCCACTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGG CTGCCAGTGAGACAGCGTCTCCTCTGGGAGCTGGGCGGGCACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGA CAGTCCTTTTGCTCTCGGAGGCCAGGGAAGATGGTACTTAGAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTC TTAACAGTACAACAGCTTCTTTGAGGACCCAGTGGGTATGGAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCA GAGTGAAAGCAGAGGCGTGAGGAGAGGAAAGCAGGGAGGTCTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGC CCCTTTCTTTCCCCGGAGTCCCTCCACCCCATAACAATACCTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACAC AGTCAGGCTTCCAGCACATTCTCCCCCATTTGGAGGATACTCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCC ATCTCTAATTATAAAACATGGTTTTGTTTTTTTTTTTTCCTTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATT TAGCAATTTAAAATCTTTCTTTACTGCAAGTTTAAATAGTTGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGT CTACTAGGCAGCCTTTGTGCCACTTCAGTGCTAGAAAGTTAAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAAT TATAAAAGTATGACCTTTTTAAATCAACCTTATTTGGATGCATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTC GTCATTGAAGGACAATTTCTTCAAAGTGGTTACAATTCATAATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACG CGCTTTTCCAGTCACACACCCCTGATGTTGGAACCAAGTTTTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAA ATGATCCAATCCAACTTGAAGTCAATTGAATATTAAGGCGCTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATT ACTCTAGATAAATTTCAAGACAGGATACTACAGGTGGCCTGCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCAT TAATTTGTCTTCCATTTGATGATACCGCAAAATTCCGTGAGTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACC TCTGTGCTCAGTGCCAGGCAAAACACTAGCTCAAAGGAGAGTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGG TTTGTTGAACTTTGGCAGCCAGTTGGTGAGGGCCAGATGTTATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCA AGCTGGCTGCAAGACTAAAGAGCTGATAACATAGTTTATTTTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACT GACCAACAAATAAACACATGTTGCCAAGATGAATCGGTCTCTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAA ATCACCACCCACTGTTCTCCCCCTTTGGGACATGTTAGGACGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTG CTCATCTAAAGATCATGTTGATATTATTCCAGGTTTTAAGATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCT AGTTTCTGTAATATTGTGTATACAAAACCCAAATCTCTCAAAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCG CACATTTTAAGTTAATTCACATAATATAAAAATTACTCAATGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGT GATACTTTAGTTAATAAAATGGTAAATTTTTTTCTCAGTTATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTG TGGGCCACAATATTGATTTTCCCATTAACAATTTTTTTTTGTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGT GTTCGCATTATCTATGTTGCTGTTACTTTTGTGCTTTTATTCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTT |
Top |
FusionGenePPI for MRPL21_SHANK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRPL21 | CUL3, MRPL40, MRPL51, MRPL32, MRPS9, MRPL19, MRPL24, MRPL38, ILF2, FAF2, C1QBP, GRSF1, BTRC, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPL39, CASQ2, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, FOXL2, C6orf203, DUSP11, NBEA, MRPL42, MTIF2, GTPBP8, AUH, MRPL20, HARS2, NDUFAF7, MRPL10, FDXR, LARS2, ELAC2, TOP3A, NDUFAF5, IARS2, CYLD | SHANK2 | CTTN, DNM2, ARHGEF7, DLGAP1, DLG4, DYNLL2, DYNLL1, MYO5A, DLGAP2, DLGAP3, DLGAP4, NLK, SHARPIN, XPO1, CDH1, EGFR, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL21_SHANK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL21_SHANK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SHANK2 | C0004352 | Autistic Disorder | 2 | CTD_human |
| Tgene | SHANK2 | C3714756 | Intellectual Disability | 1 | CTD_human |
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