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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22472

FusionGeneSummary for MRPL21_MYO1B

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL21_MYO1B
Fusion gene ID: 22472
HgeneTgene
Gene symbol

MRPL21

MYO1B

Gene ID

219927

4430

Gene namemitochondrial ribosomal protein L21myosin IB
SynonymsL21mt|MRP-L21MMI-alpha|MMIa|MYH-1c|myr1
Cytomap

11q13.3

2q32.3

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L21, mitochondrialmitochondrial large ribosomal subunit protein bL21munconventional myosin-IbMYO1B variant proteinmyosin-I alpha
Modification date2018052320180522
UniProtAcc

Q7Z2W9

O43795

Ensembl transtripts involved in fusion geneENST00000450904, ENST00000362034, 
ENST00000567045, 		ENST00000339514, 
ENST00000392318, ENST00000304164, 
ENST00000392316, ENST00000439065, 
ENST00000496992, 
Fusion gene scores* DoF score7 X 6 X 6=2526 X 6 X 3=108
# samples 87
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL21 [Title/Abstract] AND MYO1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A2BM-01AMRPL21chr11

68668016

-MYO1Bchr2

192265108

+
TCGALDBRCATCGA-AC-A2BM-01AMRPL21chr11

68668003

-MYO1Bchr2

192265108

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000450904ENST00000339514MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000450904ENST00000392318MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000450904ENST00000304164MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000450904ENST00000392316MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000450904ENST00000439065MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-intronENST00000450904ENST00000496992MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
Frame-shiftENST00000362034ENST00000339514MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
Frame-shiftENST00000362034ENST00000392318MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
Frame-shiftENST00000362034ENST00000304164MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
Frame-shiftENST00000362034ENST00000392316MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
Frame-shiftENST00000362034ENST00000439065MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
5CDS-intronENST00000362034ENST00000496992MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000567045ENST00000339514MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000567045ENST00000392318MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000567045ENST00000304164MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000567045ENST00000392316MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-3CDSENST00000567045ENST00000439065MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
intron-intronENST00000567045ENST00000496992MRPL21chr11

68668016

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000450904ENST00000339514MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000450904ENST00000392318MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000450904ENST00000304164MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000450904ENST00000392316MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000450904ENST00000439065MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-intronENST00000450904ENST00000496992MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
intron-3CDSENST00000362034ENST00000339514MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
intron-3CDSENST00000362034ENST00000392318MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
intron-3CDSENST00000362034ENST00000304164MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
intron-3CDSENST00000362034ENST00000392316MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
intron-3CDSENST00000362034ENST00000439065MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
intron-intronENST00000362034ENST00000496992MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000567045ENST00000339514MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000567045ENST00000392318MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000567045ENST00000304164MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000567045ENST00000392316MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-3CDSENST00000567045ENST00000439065MRPL21chr11

68668003

-MYO1Bchr2

192265108

+
5UTR-intronENST00000567045ENST00000496992MRPL21chr11

68668003

-MYO1Bchr2

192265108

+

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FusionProtFeatures for MRPL21_MYO1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL21

Q7Z2W9

MYO1B

O43795

Motor protein that may participate in process criticalto neuronal development and function such as cell migration,neurite outgrowth and vesicular transport. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPL21_MYO1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPL21_MYO1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRPL21CUL3, MRPL40, MRPL51, MRPL32, MRPS9, MRPL19, MRPL24, MRPL38, ILF2, FAF2, C1QBP, GRSF1, BTRC, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPL39, CASQ2, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, FOXL2, C6orf203, DUSP11, NBEA, MRPL42, MTIF2, GTPBP8, AUH, MRPL20, HARS2, NDUFAF7, MRPL10, FDXR, LARS2, ELAC2, TOP3A, NDUFAF5, IARS2, CYLDMYO1BEIF4A2, BRF2, MYC, SIRT7, TCF3, SP1, FBXO25, KIAA0368, CUL1, LRRK2, ATP6V1B1, ESR1, PAN2, RPA3, RPA2, RPA1, CUL7, CCDC8, EGFR, CSNK2A1, DAPK1, NTRK1, PTEN, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZNF746, CDH1, STYXL1, NEXN, BCL7C, BCL7A, AVIL, LSP1, CDH5, DKK3, CYLD, DLST, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPL21_MYO1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPL21_MYO1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYO1BC0043094Weight Gain1CTD_human