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Fusion gene ID: 22469 |
FusionGeneSummary for MRPL21_FAM168A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPL21_FAM168A | Fusion gene ID: 22469 | Hgene | Tgene | Gene symbol | MRPL21 | FAM168A | Gene ID | 219927 | 23201 |
| Gene name | mitochondrial ribosomal protein L21 | family with sequence similarity 168 member A | |
| Synonyms | L21mt|MRP-L21 | KIAA0280|TCRP1 | |
| Cytomap | 11q13.3 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 39S ribosomal protein L21, mitochondrialmitochondrial large ribosomal subunit protein bL21m | protein FAM168Atongue cancer chemotherapy resistance-associated protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z2W9 | Q92567 | |
| Ensembl transtripts involved in fusion gene | ENST00000450904, ENST00000362034, ENST00000567045, | ENST00000064778, ENST00000450446, ENST00000356467, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 8 X 5 X 7=280 |
| # samples | 8 | 11 | |
| ** MAII score | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/280*10)=-1.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MRPL21 [Title/Abstract] AND FAM168A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FAM168A | GO:1905053 | positive regulation of base-excision repair | 25260657 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A3KC-01A | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| TCGA | RV | LUSC | TCGA-43-6771-01A | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000450904 | ENST00000064778 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| 5UTR-intron | ENST00000450904 | ENST00000450446 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| 5UTR-intron | ENST00000450904 | ENST00000356467 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| In-frame | ENST00000362034 | ENST00000064778 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| 5CDS-intron | ENST00000362034 | ENST00000450446 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| 5CDS-intron | ENST00000362034 | ENST00000356467 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| 5UTR-3CDS | ENST00000567045 | ENST00000064778 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| 5UTR-intron | ENST00000567045 | ENST00000450446 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| 5UTR-intron | ENST00000567045 | ENST00000356467 | MRPL21 | chr11 | 68665395 | - | FAM168A | chr11 | 73122581 | - |
| Frame-shift | ENST00000450904 | ENST00000064778 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000450904 | ENST00000450446 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000450904 | ENST00000356467 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000362034 | ENST00000064778 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000362034 | ENST00000450446 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000362034 | ENST00000356467 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000567045 | ENST00000064778 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000567045 | ENST00000450446 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
| Frame-shift | ENST00000567045 | ENST00000356467 | MRPL21 | chr11 | 68660871 | - | FAM168A | chr11 | 73118688 | - |
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FusionProtFeatures for MRPL21_FAM168A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPL21 | FAM168A |
| In cancer context, protects cells from induced-DNAdamage and apoptosis. Acts, at least in part, throughPI3K/AKT/NFKB signaling pathway and by preventing POLBdegradation. Decreases POLB ubiquitation and stabilizes itsprotein levels. {ECO:0000269|PubMed:21334329,ECO:0000269|PubMed:21603883, ECO:0000269|PubMed:23251525,ECO:0000269|PubMed:25260657}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPL21_FAM168A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MRPL21_ENST00000362034_chr11_68665395_-_FAM168A_ENST00000064778_chr11_73122581_-_221aa MAASSLTVTLGRLASACSHSILRPSGPGAASLWSASRRFNSQSTSYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAGYTAGTPYKVPPT QSNTAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MRPL21_ENST00000362034_chr11_68665395_-_FAM168A_ENST00000064778_chr11_73122581_-_663nt ATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCC TCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAGTTCACCACCT TGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGGATATACTGCGGGGACACCATACAAGGTCCCACCGACC CAGAGTAACACTGCTCCACCCCCCTACTCCCCATCACCCAACCCCTATCAGACGGCCATGTATCCAATCAGAAGTGCCTACCCCCAGCAG AATCTGTATGCCCAGGGAGCCTACTACACACAGCCGGTGTATGCTGCCCAGCCTCATGTCATCCACCATACCACGGTCGTCCAGCCCAAC AGCATTCCCTCTGCTATCTACCCAGCACCTGTTGCCGCCCCGAGGACCAACGGTGTGGCCATGGGCATGGTGGCAGGCACCACCATGGCA ATGTCAGCAGGTACCCTGCTGACTACACCCCAGCACACGGCGATTGGGGCACACCCTGTCTCCATGCCAACATATAGGGCCCAAGGAACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MRPL21_ENST00000362034_chr11_68665395_-_FAM168A_ENST00000064778_chr11_73122581_-_6949nt GGCTGCGGCCATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCC CGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAG TTCACCACCTTGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGGATATACTGCGGGGACACCATACAAGGT CCCACCGACCCAGAGTAACACTGCTCCACCCCCCTACTCCCCATCACCCAACCCCTATCAGACGGCCATGTATCCAATCAGAAGTGCCTA CCCCCAGCAGAATCTGTATGCCCAGGGAGCCTACTACACACAGCCGGTGTATGCTGCCCAGCCTCATGTCATCCACCATACCACGGTCGT CCAGCCCAACAGCATTCCCTCTGCTATCTACCCAGCACCTGTTGCCGCCCCGAGGACCAACGGTGTGGCCATGGGCATGGTGGCAGGCAC CACCATGGCAATGTCAGCAGGTACCCTGCTGACTACACCCCAGCACACGGCGATTGGGGCACACCCTGTCTCCATGCCAACATATAGGGC CCAAGGAACCCCTGCGTACAGCTACGTGCCCCCACACTGGTAAAGCCTGCAGCCCATCCAAATCTGGAGTCACACATTGTATGCAACTAC TCAAGTCTTACACCGGTGCTGGAGCAGTTCCCTAGCAGCACCACCTCTATTTGCAAGAAGAGACAACGGAAGTGCAAGGGTCACTTTATG CATCTTTAATGGTTTTGATTTTTATTTTTGGTTTTTGTAAAAGCTGCTTTTTCTAATCTCCTGCCTCTCCCCAACTGTCCCCCTCTTAGC CCCTGCCCTTCCAGCTCTATCCCCTTCCTCCTACCTGACCAGGCCATGTCCTCTCTGCTCTTCCCTAAGTGTCCTGTCCCTGGGGATCCC AGTCTAGAGGCAAGCAGAGAGTAGGGTTTATTGCAGTGGTTCATCTGAAGGCTGGATTCCATTTGAAGAGCATAAACAGATGTGGTCCAG GGTAGGAACTCAGAGCTGTTGAGCAGGCTACATCTCTAGGGGAGTGTTCTGGTTGTTTTTTCTTAAGCAAGATTAGTTCAGGACATTCCC ATGTCCCAGACACAAATGAAATGTCTCCTGAGAACCATTGCAACAGACCAAGAACAAAACCACCTGAGTATGTAGGCGTGTTATTAGCAG CTTAATACCCCAGGCTGAGAACCTGGGGAAAAAAGTCTTTAGAATTTGGGGGAGGGTGGGGGGAGGGAGGGCATTGTGGGGAAGGAGAGG GAAGAAGGGAGGAGCGGTGCTTGCCTCATGGCTTTGGTTTGAAAGGTCTCTGGCCAAAGCATCTGGCCCTGGACCTTCTGATTTGCACAG TGATGTTAACTGACCTGGCACTTCCTCAAAAGGTGATTTTGTCCTTAGACCTGCCAAGCGGCTGCAGGGTGGTAGGATCCCAGCATCCCG AGGCCTTGGAAGGCCGGATGCCCTGTGTCATCCAGACTTCAGCCTCTGAGCTGTCATGGACCCACTCTGATGAGGAGCTTCCTCCTGATT GGAGTGGGAACCTAGGGCATTTCTCTCCCTTTTCTTTTGCCCTTCCCAGTGCCAGGACTCACCTGTCTGACCATAGAGCTTGCAGGCAGG CCAAGCTCTTGGTTACCTGTGCCATTCATGGCCCAAGTGAAGGAACCACATTCCAGGTGGGTGCTGGCAGCTCTGAAGGTGAGGATAGTG AAGGAAAAGCAATAGCAATAAACATTTCATAGACTCATGGAACTGAAGGGACCTTAGCAATCATCTCATCCATTTCCCTATTTGGCAGAT GAGGAAACTGAGGCCCAGAGAAGCGGAAAGGACTTCCCTAGACCTTACAGTAAATTAGCATTAAATGCAGCCTTCCTACCTAGTGGGCAC CTTGCTTACAAAAATTTACCTAGGGACGGATTGGCTTGGTTTTGTAAAAATTAAGTCGGCAGCGCCCATACCTGGTGAGTCTGGAATGGT CTCTGGGCTCCTGTTTCTGCTCTTTTCCTCCACGGACTCCAAAGGCGGGGGTTGAAGACTGGGCAGAGGCTACATGGGGGCGGATGGCAG GAACAGAAATTGCAAATGAAGAAATAGCATTTGGAAATTCTGTGAAGACATCTGGAACTTCCGTCCTGTACCTGACTCCACCTCCAGGAG AAGGAGCAGGTGGACTGGCCGAAAAGGAGAGGCCATGCTTTTAGGACAGTAGCCCCTCATCCCGAGAGGAGAGGAAGAGGAGGAAGACAG TGGGAGTCATCAGGAGAGGAGAATGAGGATGAGGCCCAGGAGACAGGCTCATCTGGGAGAAGAGGGACCCCTGGGACGAGGAGGTCCCTG CTAGTCTCAGCCAGGAGCCTGGATTGCCCAGCAGCAGCCTCCGGCACCCAGCGCTTGGCTGGGCCAGCAGCCCCTCTGGGGGTGGGGCAC GAACATTTTATTGTAAAAAATGGGATCATTGACAACATTTGGGACTTTAAAAAACTGCTTTCATTTAAAATTCATGCAAACTTGGACATA TCCTTACCCCAACCTCCCATGTCTCCCTAAGGGAGGGAAAAATCAGGAAACCCTTGGGTTGGAAGGAGCTCAGAAGCTGTCTAGCCATTC CCAGGAGGGTAAAGCCCATCAGCCTCCTTGGCCTAGAGCCAGGAGTTTGGGGGCCCACCTTCCTGGGCTTCCAAGGAACTTTAGGACCAG TAAGAAAAAATTCAGCTGTTCTAAATTATCTGTTCTGGGTGCTGATGAGGTTTCACTTTAAAACAATAGAAAGTTTTCCAGTGTTAATTC ACTTTTTGCAAATACCTCCTTCCACCCTCTTTGGTTTTGTAAAGGTGGGTGAAGGTTGTTCTAGATTATGTCATACGTGTTTGAAAAATG CCAAAATAATAATAATGATAATAATAATAGAAACCTTTGGATTTGTCAGGTGCATCACAGAGGTCAAAGCACTTCACGGCCTTTCATGTA CTCGCCCTGAGAGGGACAGGGTTAGAGTTATTACAGTCAATTGACAAATGAGGAAACAGGTTATGGAAGGGAACAGGCCCACAGTGAGCA GCATGCTGGTATCCGCTAGGCTTCCCAGAACCCTGCTGCCTCCATGTGGGCTGGGGTGGAACCACAGAGAGGAGAAAGGAAGAAGAGGAG ACCTAGGAATGACCTTGTAACTTTTGTTCTTTCAACACCAGTAAGTAAAACTAACAGCTGGACCTCACAGTTCACAGAACAGTTGAACAT AAATTATCTGGTTTAACCCGATGAAATAGAGGTTATTTCTCCTATTTGATCCATAAGGAAATCAAGGCTTGGAAAAGTCAAGTGACTTGC TAATAAGTGACAGAGCCACTCGAATCCCAGGCTGTCTGCTGTCTCGTTCCCCTCCATCTGATCCCCACACAGGCTCACGTACTGAAGCAT CTGTGCTCTGTGCCCTATCTTAGCACCTACTATGTAATTCAAGAGCAAAGGGGGGCCCCAAGGTGAAAATAAGGCACTGAAAGGCTGTGG TCTGGAAGAGCCCAGGTCCAGCACCCCTTTTTCAGTATGAGCCCCAGTTCAGCCGGCCTCAGCCTCTTGCTGTGATGGAGATCCACAAGC CTAGCCAAGCTTGGGGAGTCACTGCAAAAGGACTGAGCCCAGGAGAGCGGGGACAGTCATGTGCCTCTGGTAGGATGGGCACAGTTACTG GTAAGGTCACAGAGATCTAGTGGGAGGTACCATAGGTAGATACCTCCAAAGATTCTAGATGGCACGGTGGTCAAGCTAGACAAAAAGTCA GAGCTGGAAGGGCCGTCTCATTGAAGGCAGGCAAGCAAGAGAGGACAAGGGATGTAGCCGCCTGACAGTGAGCTACAGCACTGGCCCCAG GATGCAAACCCCTCTCTCCTCCTCATGCCACTGCCTCTCCCCAAGTGCAACACCTATGGCCAGGATCAGGGGTACAGATGGCTCGTTACC AGCCAACCCTTTTGAATTCTTCTACTTCTACCTGACCCCCTCTCCTCACTGGCCTGGGGTCAAGAAGTTTGAGTCTGGGAGCTGGATTGC CTGCAAATAGTGAAAGCCTGAAACATAATGGTTTGCCATGTTTTGAAAAAAAATGCATATTTAATTTCTTCCTCATGAGATAGGACAGTT GCTGTTCTTTCTTACCTGGCAATGACCCTAAAATGTATATCCTCTTTCCTGAATATTTAGCAGAGACACACACACCTGTCCAGAGCGTTT TTGGTATGCAAAGTACTTTGACATTGGTTGCCAAAGTCCTCCATTTTATAGATGAAAAAACTAAGGCTCAGGAGGCTTGAGACTTGCTAA AAGGTCACACAGCTTGGAAGTGATTCTTCAAATCCTCTGCTCTTTCTGCTGCCACCTGCTGGGTCTCTTGGCAAGCATGGAGGGAGGGGC TAACTGTACTTTATAGAGCTGGGAAGCCCAGTCTCTGAGCTGAGCAGATTTGTATGAACTGCTTTGGGCCAGGACCTGTAATGAGCCCTG GGGAGGGACCCAGAGGCACATCTAACTGGCAGCACAAGGAGGATGAGAATTTGCAACTAAAGGCCTCACTTGGACAAAACACTTTGGGGT CACAATGCCCAGGACCGAAGACATGTTCAAGGACAGCACGAGGCATCTTTCTATTGGGAGACCCATGTCCTTGGTAAGCCTGCACACCTG GCTTCCTAATCCCTGAGAGCCTGCCCACTGTCCAGATCCAGTGAGTTGGTACAAAACGTACAGACTGAAGTCCCTGGGCTTGCTTTTCCC ATGGGTGAGGACCAGAACCAGACTCTGAGCATCCTTACCCCTGGCCACCCGAATTGTTCCAAGTTTGAGGTACCCCGTTCCCAGAGATCT GGGGGTCCTTCTTTGGAGGGCTTGCTTTGTTCTGATGGCCTTCAGAAAGGAATCACATGAAGTATAAAAGGACAGGCCCCTTGGTCACCA AGTTTTGGCTCCTCATACAGATAGGACTCATCCAGGTTCCCAGCGAGGCACTGACTAAGCGAGGCTCAGAGCTTCCATATCAAATTCCTC AGCTTTGTTCTGTGCCCAGAGGGGGTGGGCCCCATTCTGGGCCCTGTGAACTTTGTCTTATATATCACCATCTGTATCAGAATTCCTCCT CAATTGCAGTTAAGTGAAAATACGTGGAAGTCTGCTTTTCCATCCTGTATTCTCCCACATCACTACTGGCTGTGCGGCCCCCGCTGCTTG CCAAGCTTGGGAATCCAGAGAGGGGCAGTAGTAGAGTGGGCCAGTTGGGACCCACCCGCAGAGCTGAAGAAACACGCCAGACTAACTGAT GGGATTCCACACCGGAGCCTCTGAGCGCACAGGCAGGCATGCCAAGGGGGCTGCAGGGTTTGTCCTTTACTTATCTGCCCCTTTCCTAGA AAACTCCTCGTTTCTGAAATTAGGCATTATATGGTTCCAGGACCCAGCCTTCAAAATTCCTGGCAGGCCAGCTTCAACATTCCATGGCCA GCCCTGCCTAAGCCAGACTTGGGTCCCAGTCCCTCAGTCTCTCCAGTGGATATCTTCTGTGGTGCATGCTGTTGAGTCCAACCCAAAGGC CAACCGAGGCACACAGGAGTTGGGACTGGCTGCCACAAAGCTAGAAAGGGACAAAACAGCACTTGCTTCCCTATGGCCACATGGATAGTC CCTGGATATCCTTGCTGTGGTAGAGGTCCTCTACCCATTCCAGCCACTGATAGCAGGGGGATTTTCCTTCCTAAGGAGAACAGATGTAAC AGCTTTGCAAAGTACCGGCCCATAGGAATCAAATGGGTGAGATCAGCTTTGGGCCTGACCCCAGCAAGACCAGCATCTCCAGACCCCAGC CTTTCTCCTCAGGCCTAAGAGAGTCAGGGAAAGAGAGGAGACTGTCCCAGAGACCTTCTCCTCGGGTCAGCCAGATAGTCTGGATCTATG GTGTGACTCAAGCTCCTCCTTACCCAGGGGGGGTAAGGCCAGGCCTCTAGCTACTTGGAGTTGTCTGTAATAATCTTGAAAGGCCCAAGG GCCTGTCCCCATCCTGACTTAAAGGCATCTGCTTCCCTGTTTCATATCACATGACAGAGAAACCTGTTCTCATGGCATGTAACATCCCTG TGAAGAGAGCGTTGTATATGATTTTGTATTTTTTAATTCATTTTAATCTACAGGTTGGAATCTAATTTTTAAATTTTATTGGAACTCACA TTTTAAAAAGAAATAAAATTTAAAATAATAATAATAATAATAATAATAATAATAAACCTTTGACCAGTGTCTTCCAAGTAGTTTGATCAA AGAATTTATAGGTGTTTTCAAAACACAGTCCGGAGTGTAAAGATTGGAAAGCCCCATGGCCTTGCCTGTGTGTATGAAGTGTAAATCTGG TTTTGTTTTGTTGTTTTGGATTCTTTTGGGTTTTTGTTTTGTTTTGAAGATCAGACAGTGATCACTCTGAAAGATTGAAGCCAAGAATTT GTAACTATGGTATTTACTGTAAGCTGTAGAACACTCAATAACTATTAAAAAAAAAAATTCCCCCCCAAAAAAAAGTCTTAGGTGACTAGA CTGAGTGGTTCTTGGGGAGGGAGGCACAGAGGACTGTCCTGGGCCAGTGAGTCCCTTGGGCGTCTCCCCAAGTTGATGCTAAATTTGTTC TCAGTAGTCAAGAAAAACCTATGGTACATCTTACAGCTGATCTGACAGGGGTCTGCCCTAAGGGTCTCACAGCTGCTGGGGAGCTTTAAG TGGCAACTTCAGCACCCACCCTAAGTGTGTGATGTGGGAGCACAGTGAGGCCATTCAGAGTTGAAATCCATTGAGCCATCCGCGCAATAA |
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FusionGenePPI for MRPL21_FAM168A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRPL21 | CUL3, MRPL40, MRPL51, MRPL32, MRPS9, MRPL19, MRPL24, MRPL38, ILF2, FAF2, C1QBP, GRSF1, BTRC, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPL39, CASQ2, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, FOXL2, C6orf203, DUSP11, NBEA, MRPL42, MTIF2, GTPBP8, AUH, MRPL20, HARS2, NDUFAF7, MRPL10, FDXR, LARS2, ELAC2, TOP3A, NDUFAF5, IARS2, CYLD | FAM168A | BAG3, RBFOX1, DAB1, SNRPC, UBE2V1, SF1, TAX1BP1, DAZAP2, CALCOCO2, TNIP1, RBPMS, R3HDM2, FAM168A, SS18L1, VPS37C, KLHL42, SMAP2, OTUB2, UBASH3B, C1orf94, OTULIN, NAF1, DTX2, PRR20A, MOV10, FBXO6, WWP2, EWSR1, FBXW5, MCM2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL21_FAM168A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL21_FAM168A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FAM168A | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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