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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22458

FusionGeneSummary for MRPL12_USP32

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL12_USP32
Fusion gene ID: 22458
HgeneTgene
Gene symbol

MRPL12

USP32

Gene ID

6182

84669

Gene namemitochondrial ribosomal protein L12ubiquitin specific peptidase 32
Synonyms5c5-2|L12mt|MRP-L31/34|MRPL7|MRPL7/L12|RPML12NY-REN-60|USP10
Cytomap

17q25.3

17q23.1-q23.2

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L12, mitochondrialMRP-L12mitochondrial large ribosomal subunit protein bL12mubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
Modification date2018052320180523
UniProtAcc

P52815

Q8NFA0

Ensembl transtripts involved in fusion geneENST00000333676, ENST00000300896, 
ENST00000592339, ENST00000393003, 
ENST00000586881, 
Fusion gene scores* DoF score2 X 2 X 2=812 X 7 X 6=504
# samples 212
** MAII scorelog2(2/8*10)=1.32192809488736log2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL12 [Title/Abstract] AND USP32 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMRPL12

GO:0006390

mitochondrial transcription

17337445

HgeneMRPL12

GO:0045893

positive regulation of transcription, DNA-templated

17337445


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A08O-01AMRPL12chr17

79671746

+USP32chr17

58422969

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000333676ENST00000300896MRPL12chr17

79671746

+USP32chr17

58422969

-
5CDS-intronENST00000333676ENST00000592339MRPL12chr17

79671746

+USP32chr17

58422969

-
5CDS-intronENST00000333676ENST00000393003MRPL12chr17

79671746

+USP32chr17

58422969

-
5CDS-intronENST00000333676ENST00000586881MRPL12chr17

79671746

+USP32chr17

58422969

-

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FusionProtFeatures for MRPL12_USP32


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL12

P52815

USP32

Q8NFA0

Associates with mitochondrial RNA polymerase to activatetranscription. {ECO:0000269|PubMed:22003127}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPL12_USP32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPL12_USP32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRPL12MRPL12, SRRM2, ICT1, CUL3, CUL1, CAND1, MRPL3, MRPL15, MRPL10, MRPL11, MRPS26, MRPL41, MRPL23, MRPL52, MRPL42, MRPL37, MRPS28, MRPS9, MRPL1, MRPL9, RPL12, RPL11, UFM1, RNASET2, TMEM9, SUCLG2, GADD45GIP1, HNRNPD, RBM3, PITRM1, SUCLA2, ILF3, NIT2, ACOX1, RPLP2, RPS2, AK2, XRCC1, RPL14, RPL19, RPL23, EPPK1, RPL18, RPL7A, C1QBP, NPM1, SOX2, ADRB2, COX6A2, RARG, POLR1D, OLIG1, MRPS27, TARDBP, PARK2, BTRC, MRPS30, MRPL47, MLLT1, MRPL50, CEP131, SEPT10, FOXP2, SEPT3, SDR39U1, FOXP4, MTFR1L, GTPBP8, CENPJ, MTERF2, SEPT5, TFB1M, ACSF2, SH3KBP1, C1orf122, MTG2, MTIF2, SEPT2, SEPT8, PUS1, POLRMT, RPUSD4, HARS2, TRMT2B, THOC7, GTPBP6, MTG1, SEPT6, TBRG4, SEPT9, OXNAD1, SEPT11, CCDC109B, MTERF4, SLC25A10, GFM2, FASTKD2, MRPL33, TSFM, PTPMT1, MRPL35, MRM1, MRPL53, SEPT7, THOC5, NIPSNAP3A, MRPL13, GIGYF2, THOC1, MRPL30, EZR, MRPL32, MRPL51, MRPL38, MRPL45, CD2AP, MRPL17, YARS2, MRPL19, MRPL49, RAB11FIP5, MRPL44, RDX, MRPL16, MRPL48, GATB, MALSU1, MRPL28, MRPL20, CORO1A, FTSJ2, MSN, MRPL57, MRPL39, DARS2, CLPP, MRPL27, MRPL4, MRPL22, MRPL40, MRPL55, PNPT1, NME6, KIAA0391, GFM1, BCKDK, THOC2, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, EIF5B, GPI, IDH2, PDIA3, UBE2N, CYLD, DLST, SOAT1, SOD1, VDAC1USP32CDK1, FARSA, KRT8, KRT18, KRT19, ABCD3, YWHAB, TUBA1A, SMC1A, USP6, TRIP13, ERP44, UBXN1, MRPL39, VPS35, LRRC47, USP32P2, USP4, CUL3, CAND1, RBCK1, TRIM46, RNF144A, TRIM74, ZDHHC17, RAP1B, SORT1, SYNCRIP, BAG6, FDFT1, RAB6B, TPCN2, MANSC1, ENTPD7, ALDH3B1, CD83, NME4, HSPA12A, UBC, MTNR1A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPL12_USP32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPL12_USP32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource