	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 22451

FusionGeneSummary for MRO_SLC1A2

Fusion gene summary

Fusion gene information	Fusion gene name: MRO_SLC1A2
	Fusion gene ID: 22451
		Hgene	Tgene
	Gene symbol	MRO	SLC1A2
	Gene ID	83876	6506
	Gene name	maestro	solute carrier family 1 member 2
	Synonyms	B29\|C18orf3	EAAT2\|EIEE41\|GLT-1\|HBGT
	Cytomap	18q21.2	11p13
	Type of gene	protein-coding	protein-coding
	Description	protein maestrobeside the Ma29 deletionmale-specific transcription in the developing reproductive organs	excitatory amino acid transporter 2excitotoxic amino acid transporter 2glutamate/aspartate transporter IIsodium-dependent glutamate/aspartate transporter 2solute carrier family 1 (glial high affinity glutamate transporter), member 2
	Modification date	20180402	20180519
	UniProtAcc	Q9BYG7	P43004
	Ensembl transtripts involved in fusion gene	ENST00000428869, ENST00000431965, ENST00000256425, ENST00000588444, ENST00000436348, ENST00000398439, ENST00000587291,	ENST00000278379, ENST00000395750, ENST00000395753, ENST00000606205, ENST00000479543,
Fusion gene scores	* DoF score	2 X 2 X 1=4	9 X 8 X 5=360
	# samples	2	11
	** MAII score	log2(2/4*10)=2.32192809488736	log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MRO [Title/Abstract] AND SLC1A2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SLC1A2	GO:0015813	L-glutamate transmembrane transport	26690923
Tgene	SLC1A2	GO:0070207	protein homotrimerization	15265858\|15483603
Tgene	SLC1A2	GO:0070779	D-aspartate import across plasma membrane	7521911
Tgene	SLC1A2	GO:0098712	L-glutamate import across plasma membrane	7521911\|15265858\|26690923

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF362149	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000428869	ENST00000278379	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000428869	ENST00000395750	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000428869	ENST00000395753	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000428869	ENST00000606205	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000428869	ENST00000479543	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000431965	ENST00000278379	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000431965	ENST00000395750	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000431965	ENST00000395753	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000431965	ENST00000606205	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000431965	ENST00000479543	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000256425	ENST00000278379	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000256425	ENST00000395750	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000256425	ENST00000395753	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000256425	ENST00000606205	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000256425	ENST00000479543	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000588444	ENST00000278379	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000588444	ENST00000395750	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000588444	ENST00000395753	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000588444	ENST00000606205	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000588444	ENST00000479543	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000436348	ENST00000278379	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000436348	ENST00000395750	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000436348	ENST00000395753	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000436348	ENST00000606205	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000436348	ENST00000479543	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000398439	ENST00000278379	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000398439	ENST00000395750	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000398439	ENST00000395753	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000398439	ENST00000606205	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000398439	ENST00000479543	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000587291	ENST00000278379	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000587291	ENST00000395750	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000587291	ENST00000395753	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000587291	ENST00000606205	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+
intron-intron	ENST00000587291	ENST00000479543	MRO	chr18	48335683	-	SLC1A2	chr11	35385322	+

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FusionProtFeatures for MRO_SLC1A2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MRO Q9BYG7	SLC1A2 P43004
	Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858,PubMed:26690923). Functions as a symporter that transports oneamino acid molecule together with two or three Na(+) ions and oneproton, in parallel with the counter-transport of one K(+) ion(PubMed:14506254). Mediates Cl(-) flux that is not coupled toamino acid transport; this avoids the accumulation of negativecharges due to aspartate and Na(+) symport (PubMed:14506254).Essential for the rapid removal of released glutamate from thesynaptic cleft, and for terminating the postsynaptic action ofglutamate (By similarity). {ECO:0000250\|UniProtKB:P43006,ECO:0000269\|PubMed:15265858, ECO:0000269\|PubMed:26690923,ECO:0000269\|PubMed:7521911}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MRO_SLC1A2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRO_SLC1A2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MRO_SLC1A2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	SLC1A2	P43004	DB00142	Glutamic Acid	Excitatory amino acid transporter 2	small molecule	approved\|nutraceutical

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RelatedDiseases for MRO_SLC1A2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MRO	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	SLC1A2	C0005586	Bipolar Disorder	4	PSYGENET
Tgene	SLC1A2	C0036341	Schizophrenia	4	PSYGENET
Tgene	SLC1A2	C0001973	Alcoholic Intoxication, Chronic	3	PSYGENET
Tgene	SLC1A2	C0011570	Mental Depression	3	PSYGENET
Tgene	SLC1A2	C0011581	Depressive disorder	3	PSYGENET
Tgene	SLC1A2	C0002736	Amyotrophic Lateral Sclerosis	1	CTD_human
Tgene	SLC1A2	C0014544	Epilepsy	1	CTD_human
Tgene	SLC1A2	C0027746	Nerve Degeneration	1	CTD_human
Tgene	SLC1A2	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	SLC1A2	C0236736	Cocaine-Related Disorders	1	CTD_human
Tgene	SLC1A2	C0525045	Mood Disorders	1	PSYGENET

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Fusion gene ID: 22451

FusionGeneSummary for MRO_SLC1A2

FusionProtFeatures for MRO_SLC1A2

FusionGeneSequence for MRO_SLC1A2

FusionGenePPI for MRO_SLC1A2

RelatedDrugs for MRO_SLC1A2

RelatedDiseases for MRO_SLC1A2