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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22426

FusionGeneSummary for MRC2_VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MRC2_VMP1
Fusion gene ID: 22426
HgeneTgene
Gene symbol

MRC2

VMP1

Gene ID

9902

81671

Gene namemannose receptor C type 2vacuole membrane protein 1
SynonymsCD280|CLEC13E|ENDO180|UPARAPEPG3|TANGO5|TMEM49
Cytomap

17q23.2

17q23.1

Type of geneprotein-codingprotein-coding
DescriptionC-type mannose receptor 2C-type lectin domain family 13 member EUPAR-associated proteinendocytic receptor (macrophage mannose receptor family)endocytic receptor 180macrophage mannose receptor 2urokinase-type plasminogen activator receptor-associatedvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2018052320180523
UniProtAcc

Q9UBG0

Q96GC9

Ensembl transtripts involved in fusion geneENST00000303375, ENST00000446119, 
ENST00000580916, 
ENST00000262291, 
ENST00000537567, ENST00000539763, 
ENST00000536180, ENST00000545362, 
ENST00000588617, 
Fusion gene scores* DoF score9 X 7 X 5=31524 X 11 X 12=3168
# samples 1027
** MAII scorelog2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/3168*10)=-3.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRC2 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMRC2

GO:0030574

collagen catabolic process

12972549


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-58-8386-01AMRC2chr17

60751531

+VMP1chr17

57917129

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000303375ENST00000262291MRC2chr17

60751531

+VMP1chr17

57917129

+
Frame-shitENST00000303375ENST00000537567MRC2chr17

60751531

+VMP1chr17

57917129

+
Frame-shitENST00000303375ENST00000539763MRC2chr17

60751531

+VMP1chr17

57917129

+
Frame-shitENST00000303375ENST00000536180MRC2chr17

60751531

+VMP1chr17

57917129

+
In-frameENST00000303375ENST00000545362MRC2chr17

60751531

+VMP1chr17

57917129

+
5CDS-3UTRENST00000303375ENST00000588617MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000446119ENST00000262291MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000446119ENST00000537567MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000446119ENST00000539763MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000446119ENST00000536180MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000446119ENST00000545362MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3UTRENST00000446119ENST00000588617MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000580916ENST00000262291MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000580916ENST00000537567MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000580916ENST00000539763MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000580916ENST00000536180MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3CDSENST00000580916ENST00000545362MRC2chr17

60751531

+VMP1chr17

57917129

+
intron-3UTRENST00000580916ENST00000588617MRC2chr17

60751531

+VMP1chr17

57917129

+

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FusionProtFeatures for MRC2_VMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRC2

Q9UBG0

VMP1

Q96GC9

May play a role as endocytotic lectin receptordisplaying calcium-dependent lectin activity. Internalizesglycosylated ligands from the extracellular space for release inan endosomal compartment via clathrin-mediated endocytosis. May beinvolved in plasminogen activation system controlling theextracellular level of PLAUR/PLAU, and thus may regulate proteaseactivity at the cell surface. May contribute to cellular uptake,remodeling and degradation of extracellular collagen matrices. Mayplay a role during cancer progression as well as in other chronictissue destructive diseases acting on collagen turnover. Mayparticipate in remodeling of extracellular matrix cooperating withthe matrix metalloproteinases (MMPs).{ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}. Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRC2_VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MRC2_ENST00000303375_chr17_60751531_+_VMP1_ENST00000545362_chr17_57917129_+_571aa
MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGT
MQCLGTGWPGTNTTASLGMTECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQG
NSHGKPCTIPFKTDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQG
ADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPTVCK
KKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQ
MNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGENWLSWMFEKLVVVMV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MRC2_ENST00000303375_chr17_60751531_+_VMP1_ENST00000545362_chr17_57917129_+_1713nt
ATGGGGCCCGGCCGGCCGGCCCCCGCGCCCTGGCCTCGTCACCTGCTGCGCTGCGTCCTGCTCCTCGGGTGCCTGCACCTCGGCCGTCCC
GGCGCCCCTGGGGACGCCGCCCTCCCGGAACCCAACGTCTTCCTCATCTTCAGCCATGGACTGCAGGGCTGCCTGGAGGCCCAGGGCGGG
CAGGTCAGAGTCACCCCGGCTTGCAATACCAGCCTCCCTGCCCAGCGCTGGAAGTGGGTCTCCCGAAACCGGCTATTCAACCTGGGTACC
ATGCAGTGCCTGGGCACAGGCTGGCCAGGCACCAACACCACGGCCTCCCTGGGCATGTATGAGTGTGACCGGGAAGCACTGAATCTTCGC
TGGCATTGTCGTACACTGGGTGACCAGCTGTCCTTGCTCCTGGGGGCCCGCACCAGCAACATATCCAAGCCTGGCACCCTTGAGCGTGGT
GACCAGACCCGCAGTGGCCAGTGGCGCATCTACGGCAGCGAGGAGGACCTATGTGCTCTGCCCTACCACGAGGTCTACACCATCCAGGGA
AACTCCCACGGAAAGCCGTGCACCATCCCCTTCAAATATGACAACCAGTGGTTCCACGGCTGCACCAGCACGGGCCGCGAGGATGGTCAC
CTGTGGTGTGCCACCACCCAGGACTACGGCAAAGACGAGCGCTGGGGCTTCTGCCCCATCAAGAGTAACGACTGCGAGACCTTCTGGGAC
AAGGACCAGCTGACTGACAGCTGCTACCAGTTTAACTTCCAGTCCACGCTGTCGTGGAGGGAGGCCTGGGCCAGCTGCGAGCAGCAGGGT
GCGGATCTGCTGAGCATCACGGAGATCCACGAGCAGACCTACATCAACGGCCTCCTCACTGGGTACAGCTCCACCCTGTGGATCGGCTTG
AATGACTTGGACACGAGCGGAGGCTGGCAGTGGTCGGACAACTCGCCCCTCAAGTACCTCAACTGGGAGAGTGACCAGCCGGACAACCCC
AGTGAGGAGAACTGTGGAGTGATCCGCACTGAGTCCTCGGGCGGCTGGCAGAACCGTGACTGCAGCATCGCGCTGCCCTATGTGTGCAAG
AAGAAGCCCAACGCCACGGCCGAGCCCACCCCTCCAGACAGGTGGGCCAATGTGAAGGTGGAGTGCGAGCCGAGCTGGCAGCCCTTCCAG
GGCCACTGCTACCGCCTGCAGGCCGAGAAGCGCAGCTGGCAGGAGTCCAAGAAGGCATGTCTACGGGGCGGTGGCGACCTGGTCAGCATC
CACAGCATGGCGGAGCTGGAATTCATCACCAAGCAGATCAAGCAAGAGGTGGAGGAGCTGTGGATCGGCCTCAACGATTTGAAACTGCAG
ATGAATTTTGAGTGGTCTGACGGGAGCCTTGTGAGCTTCACCCACTGGCACCCCTTTGAGCCCAACAACTTCCGGGACAGTCTGGAGGAC
TGTGTCACCATCTGGGGCCCGGAAGGCCGCTGGAACGACAGTCCCTGTAACCAGTCCTTGCCATCCATCTGCAAGAAGGCAGGCCAGCTG
AGCCAGGGGGCCGCCGAGGAGGACCATGGCTGCCGGAAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTG
TGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MRC2_ENST00000303375_chr17_60751531_+_VMP1_ENST00000545362_chr17_57917129_+_2367nt
GAAGGCGAGGCGGGGAGAGACTGGGAAACAGAGCAGCAAGAGAAAGGGCGCACGCTGGGGTCCTCCTGGACCCGGCGTGTCCTCCTCTCC
GCCACCCCTTTCTCTCCCTCCCGACGCTCTAGCCCCAGACCCGCGCCTCCTCCCCTTCCCCTCCCACGCTGCCCACTTCCCTTCCCCTCT
ACCCCTCGAACCCTCCTCCCCGGTTCTGCGCTCCTCCCTCCGCCCTCCCTCCGCCCGGGCTGCCTCCTCCCTCCTCCTCCCCGGGAGGCA
TCACTTCGTCCCGACCCGGAGGAGGACGCGAGCCCCTTGCGGGCGGTCATCACAGCCCAGCCTCGGGGCTGCCACAGCGCGTTGCGCCTG
TGCGCCCTCGGTCCCCGCGTCCACTGAGCGCCGCGCTCGGGGATGGGGCCCGGCCGGCCGGCCCCCGCGCCCTGGCCTCGTCACCTGCTG
CGCTGCGTCCTGCTCCTCGGGTGCCTGCACCTCGGCCGTCCCGGCGCCCCTGGGGACGCCGCCCTCCCGGAACCCAACGTCTTCCTCATC
TTCAGCCATGGACTGCAGGGCTGCCTGGAGGCCCAGGGCGGGCAGGTCAGAGTCACCCCGGCTTGCAATACCAGCCTCCCTGCCCAGCGC
TGGAAGTGGGTCTCCCGAAACCGGCTATTCAACCTGGGTACCATGCAGTGCCTGGGCACAGGCTGGCCAGGCACCAACACCACGGCCTCC
CTGGGCATGTATGAGTGTGACCGGGAAGCACTGAATCTTCGCTGGCATTGTCGTACACTGGGTGACCAGCTGTCCTTGCTCCTGGGGGCC
CGCACCAGCAACATATCCAAGCCTGGCACCCTTGAGCGTGGTGACCAGACCCGCAGTGGCCAGTGGCGCATCTACGGCAGCGAGGAGGAC
CTATGTGCTCTGCCCTACCACGAGGTCTACACCATCCAGGGAAACTCCCACGGAAAGCCGTGCACCATCCCCTTCAAATATGACAACCAG
TGGTTCCACGGCTGCACCAGCACGGGCCGCGAGGATGGTCACCTGTGGTGTGCCACCACCCAGGACTACGGCAAAGACGAGCGCTGGGGC
TTCTGCCCCATCAAGAGTAACGACTGCGAGACCTTCTGGGACAAGGACCAGCTGACTGACAGCTGCTACCAGTTTAACTTCCAGTCCACG
CTGTCGTGGAGGGAGGCCTGGGCCAGCTGCGAGCAGCAGGGTGCGGATCTGCTGAGCATCACGGAGATCCACGAGCAGACCTACATCAAC
GGCCTCCTCACTGGGTACAGCTCCACCCTGTGGATCGGCTTGAATGACTTGGACACGAGCGGAGGCTGGCAGTGGTCGGACAACTCGCCC
CTCAAGTACCTCAACTGGGAGAGTGACCAGCCGGACAACCCCAGTGAGGAGAACTGTGGAGTGATCCGCACTGAGTCCTCGGGCGGCTGG
CAGAACCGTGACTGCAGCATCGCGCTGCCCTATGTGTGCAAGAAGAAGCCCAACGCCACGGCCGAGCCCACCCCTCCAGACAGGTGGGCC
AATGTGAAGGTGGAGTGCGAGCCGAGCTGGCAGCCCTTCCAGGGCCACTGCTACCGCCTGCAGGCCGAGAAGCGCAGCTGGCAGGAGTCC
AAGAAGGCATGTCTACGGGGCGGTGGCGACCTGGTCAGCATCCACAGCATGGCGGAGCTGGAATTCATCACCAAGCAGATCAAGCAAGAG
GTGGAGGAGCTGTGGATCGGCCTCAACGATTTGAAACTGCAGATGAATTTTGAGTGGTCTGACGGGAGCCTTGTGAGCTTCACCCACTGG
CACCCCTTTGAGCCCAACAACTTCCGGGACAGTCTGGAGGACTGTGTCACCATCTGGGGCCCGGAAGGCCGCTGGAACGACAGTCCCTGT
AACCAGTCCTTGCCATCCATCTGCAAGAAGGCAGGCCAGCTGAGCCAGGGGGCCGCCGAGGAGGACCATGGCTGCCGGAAGGGAGAAAAC
TGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCC
AAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTG
CCTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTA
GTCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTG


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FusionGenePPI for MRC2_VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRC2NDEL1, FBXO6, LGALS3, LGALS8, LGALS9, AKT1, BAG4, BRMS1, ESR2, PALB2, PAX2, PPM1D, PTPN1, RAF1, RB1CC1, XRCC3, FAM19A4, ST8SIA4, FAM19A3, LMAN2L, SCGB1D1, CER1, LYZL2, KNG1, TALDO1VMP1HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRC2_VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRC2_VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMRC2C0024667Animal Mammary Neoplasms1CTD_human
HgeneMRC2C0024668Mammary Neoplasms, Experimental1CTD_human