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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22421

FusionGeneSummary for MRC2_PHYHIPL

check button Fusion gene summary
Fusion gene informationFusion gene name: MRC2_PHYHIPL
Fusion gene ID: 22421
HgeneTgene
Gene symbol

MRC2

PHYHIPL

Gene ID

9902

84457

Gene namemannose receptor C type 2phytanoyl-CoA 2-hydroxylase interacting protein like
SynonymsCD280|CLEC13E|ENDO180|UPARAP-
Cytomap

17q23.2

10q21.1

Type of geneprotein-codingprotein-coding
DescriptionC-type mannose receptor 2C-type lectin domain family 13 member EUPAR-associated proteinendocytic receptor (macrophage mannose receptor family)endocytic receptor 180macrophage mannose receptor 2urokinase-type plasminogen activator receptor-associatedphytanoyl-CoA hydroxylase-interacting protein-like
Modification date2018052320180519
UniProtAcc

Q9UBG0

Q96FC7

Ensembl transtripts involved in fusion geneENST00000303375, ENST00000446119, 
ENST00000580916, 		ENST00000373880, 
ENST00000433653, ENST00000373878, 
ENST00000472199, 
Fusion gene scores* DoF score9 X 7 X 5=3155 X 4 X 3=60
# samples 104
** MAII scorelog2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRC2 [Title/Abstract] AND PHYHIPL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMRC2

GO:0030574

collagen catabolic process

12972549


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A8IC-01AMRC2chr17

60705281

+PHYHIPLchr10

61004817

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000303375ENST00000373880MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
5CDS-intronENST00000303375ENST00000433653MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
5CDS-intronENST00000303375ENST00000373878MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
5CDS-intronENST00000303375ENST00000472199MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-3CDSENST00000446119ENST00000373880MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-intronENST00000446119ENST00000433653MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-intronENST00000446119ENST00000373878MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-intronENST00000446119ENST00000472199MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-3CDSENST00000580916ENST00000373880MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-intronENST00000580916ENST00000433653MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-intronENST00000580916ENST00000373878MRC2chr17

60705281

+PHYHIPLchr10

61004817

+
intron-intronENST00000580916ENST00000472199MRC2chr17

60705281

+PHYHIPLchr10

61004817

+

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FusionProtFeatures for MRC2_PHYHIPL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRC2

Q9UBG0

PHYHIPL

Q96FC7

May play a role as endocytotic lectin receptordisplaying calcium-dependent lectin activity. Internalizesglycosylated ligands from the extracellular space for release inan endosomal compartment via clathrin-mediated endocytosis. May beinvolved in plasminogen activation system controlling theextracellular level of PLAUR/PLAU, and thus may regulate proteaseactivity at the cell surface. May contribute to cellular uptake,remodeling and degradation of extracellular collagen matrices. Mayplay a role during cancer progression as well as in other chronictissue destructive diseases acting on collagen turnover. Mayparticipate in remodeling of extracellular matrix cooperating withthe matrix metalloproteinases (MMPs).{ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}. May play a role in the development of the centralsystem. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHYHIPLchr17:60705281chr10:61004817ENST00000433653+0252_161-1950DomainFibronectin type-III

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+1301132_1243391480DomainC-type lectin 7
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+1301273_1393391480DomainC-type lectin 8
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+130182_230391480DomainFibronectin type-II
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+130244_360391480DomainC-type lectin 1
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+130389_505391480DomainC-type lectin 2
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+13041_167391480DomainRicin B-type lectin
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+130528_644391480DomainC-type lectin 3
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+130678_809391480DomainC-type lectin 4
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+130832_951391480DomainC-type lectin 5
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+130979_1107391480DomainC-type lectin 6
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+1301436_1479391480Topological domainCytoplasmic
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+13031_1414391480Topological domainExtracellular
HgeneMRC2chr17:60705281chr10:61004817ENST00000303375+1301415_1435391480TransmembraneHelical
TgenePHYHIPLchr17:60705281chr10:61004817ENST00000373878+3552_161172351DomainFibronectin type-III
TgenePHYHIPLchr17:60705281chr10:61004817ENST00000373880+3552_161198377DomainFibronectin type-III


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FusionGeneSequence for MRC2_PHYHIPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MRC2_ENST00000303375_chr17_60705281_+_PHYHIPL_ENST00000373880_chr10_61004817_+_217aa
MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPENIMGMLCSHLSRITVVAMALLSVENXKASSSAAALNSILESHPRIHLMED
TGLRLPQKNFLTPILTYTLGTSTVCTLLIIMXFLLLLLWDHQEMNFVSSAFLNXILRIINFXPVQKKMGCWFTTMPRMSFXKSFTLTLWI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MRC2_ENST00000303375_chr17_60705281_+_PHYHIPL_ENST00000373880_chr10_61004817_+_653nt
ATGGGGCCCGGCCGGCCGGCCCCCGCGCCCTGGCCTCGTCACCTGCTGCGCTGCGTCCTGCTCCTCGGGTGCCTGCACCTCGGCCGTCCC
GGCGCCCCTGGGGACGCCGCCCTCCCGGAGAACATCATGGGAATGCTATGCAGCCATCTGTCAAGGATAACAGTGGTAGCCATGGCTCTC
CTATCAGTGGAAAATTAGAAGGCATCTTCTTCAGCTGCAGCACTGAATTCAATACTGGAAAGCCACCCCAGGATTCACCTTATGGAAGAT
ACAGGTTTGAGATTGCCGCAGAAAAACTTTTTAACCCCAATACTAACTTATACTTTGGGGACTTCTACTGTATGTACACTGCTTATCATT
ATGTGATTCTTGTTATTGCTCCTGTGGGATCACCAGGAGATGAATTTTGTAAGCAGCGCCTTCCTCAACTAAATTCTAAGGATAATAAAT
TTTTGACCTGTACAGAAGAAGATGGGGTGCTGGTTTACCACCATGCCCAGGATGTCATTTTAGAAGTCATTTACACTGACCCTGTGGATC
TTTCTGTGGGCACCGTGGCAGAAATCACTGGTCATCAGCTCATGAGTTTGTCTACTGCAAATGCAAAGAAAGATCCCAGCTGCAAAACCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MRC2_ENST00000303375_chr17_60705281_+_PHYHIPL_ENST00000373880_chr10_61004817_+_3238nt
GAAGGCGAGGCGGGGAGAGACTGGGAAACAGAGCAGCAAGAGAAAGGGCGCACGCTGGGGTCCTCCTGGACCCGGCGTGTCCTCCTCTCC
GCCACCCCTTTCTCTCCCTCCCGACGCTCTAGCCCCAGACCCGCGCCTCCTCCCCTTCCCCTCCCACGCTGCCCACTTCCCTTCCCCTCT
ACCCCTCGAACCCTCCTCCCCGGTTCTGCGCTCCTCCCTCCGCCCTCCCTCCGCCCGGGCTGCCTCCTCCCTCCTCCTCCCCGGGAGGCA
TCACTTCGTCCCGACCCGGAGGAGGACGCGAGCCCCTTGCGGGCGGTCATCACAGCCCAGCCTCGGGGCTGCCACAGCGCGTTGCGCCTG
TGCGCCCTCGGTCCCCGCGTCCACTGAGCGCCGCGCTCGGGGATGGGGCCCGGCCGGCCGGCCCCCGCGCCCTGGCCTCGTCACCTGCTG
CGCTGCGTCCTGCTCCTCGGGTGCCTGCACCTCGGCCGTCCCGGCGCCCCTGGGGACGCCGCCCTCCCGGAGAACATCATGGGAATGCTA
TGCAGCCATCTGTCAAGGATAACAGTGGTAGCCATGGCTCTCCTATCAGTGGAAAATTAGAAGGCATCTTCTTCAGCTGCAGCACTGAAT
TCAATACTGGAAAGCCACCCCAGGATTCACCTTATGGAAGATACAGGTTTGAGATTGCCGCAGAAAAACTTTTTAACCCCAATACTAACT
TATACTTTGGGGACTTCTACTGTATGTACACTGCTTATCATTATGTGATTCTTGTTATTGCTCCTGTGGGATCACCAGGAGATGAATTTT
GTAAGCAGCGCCTTCCTCAACTAAATTCTAAGGATAATAAATTTTTGACCTGTACAGAAGAAGATGGGGTGCTGGTTTACCACCATGCCC
AGGATGTCATTTTAGAAGTCATTTACACTGACCCTGTGGATCTTTCTGTGGGCACCGTGGCAGAAATCACTGGTCATCAGCTCATGAGTT
TGTCTACTGCAAATGCAAAGAAAGATCCCAGCTGCAAAACCTGTAATATCAGTGTTGGACGTTAATGCCCACTTTTCTTATTCTTACTCA
GCCCCTTTTCCTCCCTTAGGAGCATTGGTCCTCTGTTGTCCATTTTTATCACCAGATGTTTTCCACTGAAGCATGCACATGCCACTGTCA
CCAAAACAAACAACTACCACTTTCCAAATTTCATTCAGAACCATTTTAGTGTTTTCCTATTCCCTACCCCTCCCACTACTTTCAATGATG
AAATACCCTAAGTTAAGTTCTCCTTTTGACACTTTATTGCCTAGATGCTGCAATGTTTTTATGTTTCCTTTATGCCAAACATAACAAAAC
AGTTATATAGACTGCTTTAGCAAAGTACACAATAATGGCTTATAAATGGTGTTTAAATATGCATTCATTTTAATCTACTGAACAAATATT
GGGATAACTCCAAACCGCATGAAAGGGTGTAATTGCAGCATGAGTTAAATCTTGAAGCCTAGAATTGTCAGCACTTCCAACTTCTTGTTT
GACAGTGTTATTTATGTTATTTATATTAGCTAACAGGAAACAACTACTGTGTTTCAACATAATAAATATAATAGAAAAATATTTTATTTG
TATTGTTGTATAAAATATTTACAATCATATAGAATATATAGAGTTACATTTTAATAGCAACTGTGTACATGTCACGAAACCATTTCCCTT
ATCAAAGATGTAATTTGTAAACCTCAAATAGTTGTGTATCTGTCCTGTTAGAAGTAGATGACTTCAATTAAACAAATTTATGAAGGACAT
TATTCTGATTCATAAAAGTTATAAAATATTAGGTAAATACAGAGAAAACAATAAGCCTCTGAAATAAGTCTGTTTCTGAAATAGTCAATA
GTCTTCCCATCCAAACTATAAGAGAATGTGAATTTCTTCAACATCATACTTAAACATTACAGAAAATAGAAATACAAACAAGGTTGGTAC
ATGAGAGAAAATGTTGACCTTTTACTTCCTTTTACAAAAATGAAAATAATAAACATGTTTTCGTATAAAATAACACAAAATGATATACAC
TGAAGTTGATGAAGCAAATAAATATTCTGGCTTCTTTTTCAAGGTATCAGGGCAAACAATTTCCAAACTTTTCATTTTGTACAGAAGGAT
GAATAACTACAGCTCATGGGAAATGTTTTGACTTTACAAAGTATAGATGTTGGAACATTAAGAAAAATGTATATTCCCAATGAAAAAATA
GTTATATCATCTTATAGTAAACCAAAAGATTAGCAATAATACTATGGACACATTAGATTATATACTACAGACACATATCTATCCAAAATA
CCTATTTTAAATTTTTAATACAATATTTTATTTTAATATAAACATCTGTCAGTTATAGACAAAGATAATAATTCACAAAGTACATGCTAT
CAGAATGAACTTTGGTAACCAGAAATGTAAAATTTCAAATAACGGATAAAATAATGTGTTATTTTTATAGAGAAAGAAAAAAATAGCAAC
ACAATCTAGTTTATTTTAGGGTACTGAGAGCCTAGCAGACTTAAAGGACAAGGTAGTAAATGTTTTATCACTCAAAAATCCATTAGAAGT
TTCAAATAAATTGCTTTCTTGCTAGCTGTATTCCTTCCTACTTGAAAAGCGAATTTCTTTTCCTCCTATGATTGATTTTTTAAAATCATG
CTCTTTTCCATACATCAACATAAACAGTCTTTGGATACTAAATAAACTTTCCCTAACAAGTGTCCTAGCTATGTTATTTAGATTTGATAA
AATATTAGACATTTTTAAAAATACTTGTATTGACTATGAGTTTTCTGCTTGGCATGGAGGACACTGAATTTTTTCCCAATTATATGGCTA
CCTGTTGTATTCTTCCCCCCGTTTAAATCCCTTCTCCTTGTATATAATTAAACTTGCTATTCCTTCTTAAAAACAGCTAATACTACCACT
AAAGTGCTTCCATTTTCATTGTGTCAAAACTACTTAGCAAGGATGGCAGAGGAAAATAAACTTTACTTTATATCATGGGTGAAAGTGATC
ATAACATTTCCTGAACCTCAAATAGTTTTGGCCACATCTTGCTTGCTGATGAGGACCTCTAATAGTCTCAGTTTGGCTTTTATGTGCTTA


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FusionGenePPI for MRC2_PHYHIPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MRC2NDEL1, FBXO6, LGALS3, LGALS8, LGALS9, AKT1, BAG4, BRMS1, ESR2, PALB2, PAX2, PPM1D, PTPN1, RAF1, RB1CC1, XRCC3, FAM19A4, ST8SIA4, FAM19A3, LMAN2L, SCGB1D1, CER1, LYZL2, KNG1, TALDO1PHYHIPLPDE9A, TMCO6, HSPB1, PHYHIPL, OPA3, LOC102724023, DHRS4, PMPCB, STARD7, ECH1, C1QBP, ACOT7, ERRFI1, DNAAF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRC2_PHYHIPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRC2_PHYHIPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMRC2C0024667Animal Mammary Neoplasms1CTD_human
HgeneMRC2C0024668Mammary Neoplasms, Experimental1CTD_human