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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22419

FusionGeneSummary for MRC2_GNA12

check button Fusion gene summary
Fusion gene informationFusion gene name: MRC2_GNA12
Fusion gene ID: 22419
HgeneTgene
Gene symbol

MRC2

GNA12

Gene ID

9902

2768

Gene namemannose receptor C type 2G protein subunit alpha 12
SynonymsCD280|CLEC13E|ENDO180|UPARAPNNX3|RMP|gep
Cytomap

17q23.2

7p22.3-p22.2

Type of geneprotein-codingprotein-coding
DescriptionC-type mannose receptor 2C-type lectin domain family 13 member EUPAR-associated proteinendocytic receptor (macrophage mannose receptor family)endocytic receptor 180macrophage mannose receptor 2urokinase-type plasminogen activator receptor-associatedguanine nucleotide-binding protein subunit alpha-12WUGSC:H_GS165O14.2g alpha-12guanine nucleotide binding protein (G protein) alpha 12
Modification date2018052320180523
UniProtAcc

Q9UBG0

Q03113

Ensembl transtripts involved in fusion geneENST00000303375, ENST00000446119, 
ENST00000580916, 
ENST00000275364, 
ENST00000544127, ENST00000491117, 
ENST00000407904, ENST00000407653, 
ENST00000396960, 
Fusion gene scores* DoF score9 X 7 X 5=3156 X 5 X 4=120
# samples 107
** MAII scorelog2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRC2 [Title/Abstract] AND GNA12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMRC2

GO:0030574

collagen catabolic process

12972549


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF675674MRC2chr17

60746475

-GNA12chr7

2820977

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000303375ENST00000275364MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000303375ENST00000544127MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000303375ENST00000491117MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000303375ENST00000407904MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000303375ENST00000407653MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000303375ENST00000396960MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000446119ENST00000275364MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000446119ENST00000544127MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000446119ENST00000491117MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000446119ENST00000407904MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000446119ENST00000407653MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000446119ENST00000396960MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000580916ENST00000275364MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000580916ENST00000544127MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000580916ENST00000491117MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000580916ENST00000407904MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000580916ENST00000407653MRC2chr17

60746475

-GNA12chr7

2820977

-
intron-intronENST00000580916ENST00000396960MRC2chr17

60746475

-GNA12chr7

2820977

-

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FusionProtFeatures for MRC2_GNA12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRC2

Q9UBG0

GNA12

Q03113

May play a role as endocytotic lectin receptordisplaying calcium-dependent lectin activity. Internalizesglycosylated ligands from the extracellular space for release inan endosomal compartment via clathrin-mediated endocytosis. May beinvolved in plasminogen activation system controlling theextracellular level of PLAUR/PLAU, and thus may regulate proteaseactivity at the cell surface. May contribute to cellular uptake,remodeling and degradation of extracellular collagen matrices. Mayplay a role during cancer progression as well as in other chronictissue destructive diseases acting on collagen turnover. Mayparticipate in remodeling of extracellular matrix cooperating withthe matrix metalloproteinases (MMPs).{ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRC2_GNA12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRC2_GNA12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRC2_GNA12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRC2_GNA12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMRC2C0024667Animal Mammary Neoplasms1CTD_human
HgeneMRC2C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneGNA12C0009324Ulcerative Colitis1CTD_human
TgeneGNA12C0033975Psychotic Disorders1PSYGENET
TgeneGNA12C0151744Myocardial Ischemia1CTD_human
TgeneGNA12C0349204Nonorganic psychosis1PSYGENET