|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22418 |
FusionGeneSummary for MRC1_ALOX5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRC1_ALOX5 | Fusion gene ID: 22418 | Hgene | Tgene | Gene symbol | MRC1 | ALOX5 | Gene ID | 4360 | 240 |
| Gene name | mannose receptor C-type 1 | arachidonate 5-lipoxygenase | |
| Synonyms | CD206|CLEC13D|CLEC13DL|MMR|MRC1L1|bA541I19.1|hMR | 5-LO|5-LOX|5LPG|LOG5 | |
| Cytomap | 10p12.33 | 10q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | macrophage mannose receptor 1C-type lectin domain family 13 member Dhuman mannose receptormacrophage mannose receptor 1-like protein 1mannose receptor, C type 1-like 1 | arachidonate 5-lipoxygenaseLOX-5arachidonic 5-lipoxygenase alpha-10 isoformarachidonic 5-lipoxygenase delta-10-13 isoformarachidonic 5-lipoxygenase delta-13 isoformarachidonic 5-lipoxygenase delta-p10 isoformarachidonic acid 5-lipoxygenaseleukotrie | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P22897 | P09917 | |
| Ensembl transtripts involved in fusion gene | ENST00000239761, | ENST00000542434, ENST00000374391, ENST00000493336, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MRC1 [Title/Abstract] AND ALOX5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MRC1 | GO:0006898 | receptor-mediated endocytosis | 20035344 |
| Tgene | ALOX5 | GO:0019370 | leukotriene biosynthetic process | 21233389 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-MR-A8JO-01A | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000239761 | ENST00000542434 | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
| Frame-shift | ENST00000239761 | ENST00000374391 | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
| 5CDS-intron | ENST00000239761 | ENST00000493336 | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
Top |
FusionProtFeatures for MRC1_ALOX5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRC1 | ALOX5 |
| Mediates the endocytosis of glycoproteins bymacrophages. Binds both sulfated and non-sulfated polysaccharidechains. (Microbial infection) Acts as phagocytic receptor forbacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Denguevirus envelope protein E. {ECO:0000269|PubMed:18266465}. (Microbial infection) Interacts with Hepatitis B virusenvelope protein. {ECO:0000269|PubMed:19683778}. | Catalyzes the first step in leukotriene biosynthesis,and thereby plays a role in inflammatory processes.{ECO:0000269|PubMed:21233389}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MRC1_ALOX5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MRC1_ALOX5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRC1 | ATP4A | ALOX5 | COTL1, TGFBRAP1, GRB2, APP, LTC4S, ALOX5AP, MAPKAPK2, DICER1, PIK3R1, MEOX1, REL, MAD1L1, HHIPL2, CEP63, SYCE1, NUTM1, CEP57L1, RELA, ALPL, RUNDC1, SLAIN1, TBC1D2B, LSS, KDM3B, TPP2, MPP5, NCSTN, OSBPL11, CKAP5, RNF6, CAMKK2, PNPLA2, MND1, MTMR4, DDHD2, RAB3GAP1, KIF16B, PSMF1, AMOT, DMWD, TRIM65, ERCC6L, PMF1, ITSN1, MTMR3, C14orf80, ADSL, COG2, PDXDC2P, CDC16, AMOTL1, NFKB2, ERMP1, MADD, ARMCX5, RPS6KA2, NEU3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MRC1_ALOX5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MRC1 | P22897 | DB09266 | Technetium Tc-99m tilmanocept | Macrophage mannose receptor 1 | small molecule | approved|investigational |
| Tgene | ALOX5 | P09917 | DB00233 | Aminosalicylic Acid | Arachidonate 5-lipoxygenase | small molecule | approved |
| Tgene | ALOX5 | P09917 | DB00244 | Mesalazine | Arachidonate 5-lipoxygenase | small molecule | approved |
| Tgene | ALOX5 | P09917 | DB00471 | Montelukast | Arachidonate 5-lipoxygenase | small molecule | approved |
| Tgene | ALOX5 | P09917 | DB00795 | Sulfasalazine | Arachidonate 5-lipoxygenase | small molecule | approved |
| Tgene | ALOX5 | P09917 | DB09285 | Morniflumate | Arachidonate 5-lipoxygenase | small molecule | approved |
| Tgene | ALOX5 | P09917 | DB00179 | Masoprocol | Arachidonate 5-lipoxygenase | small molecule | approved|investigational |
| Tgene | ALOX5 | P09917 | DB01014 | Balsalazide | Arachidonate 5-lipoxygenase | small molecule | approved|investigational |
| Tgene | ALOX5 | P09917 | DB01017 | Minocycline | Arachidonate 5-lipoxygenase | small molecule | approved|investigational |
| Tgene | ALOX5 | P09917 | DB11994 | Diacerein | Arachidonate 5-lipoxygenase | small molecule | approved|investigational |
| Tgene | ALOX5 | P09917 | DB00711 | Diethylcarbamazine | Arachidonate 5-lipoxygenase | small molecule | approved|investigational|vet_approved |
| Tgene | ALOX5 | P09917 | DB00586 | Diclofenac | Arachidonate 5-lipoxygenase | small molecule | approved|vet_approved |
| Tgene | ALOX5 | P09917 | DB00939 | Meclofenamic acid | Arachidonate 5-lipoxygenase | small molecule | approved|vet_approved |
Top |
RelatedDiseases for MRC1_ALOX5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MRC1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| Tgene | ALOX5 | C0009375 | Colonic Neoplasms | 2 | CTD_human |
| Tgene | ALOX5 | C0023473 | Myeloid Leukemia, Chronic | 2 | CTD_human |
| Tgene | ALOX5 | C0001430 | Adenoma | 1 | CTD_human |
| Tgene | ALOX5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | ALOX5 | C0004153 | Atherosclerosis | 1 | CTD_human |
| Tgene | ALOX5 | C0009319 | Colitis | 1 | CTD_human |
| Tgene | ALOX5 | C0009376 | Colonic Polyps | 1 | CTD_human |
| Tgene | ALOX5 | C0011609 | Drug Eruptions | 1 | CTD_human |
| Tgene | ALOX5 | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | ALOX5 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| Tgene | ALOX5 | C0026766 | Multiple Organ Failure | 1 | CTD_human |
| Tgene | ALOX5 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | ALOX5 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | ALOX5 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | ALOX5 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | ALOX5 | C0042109 | Urticaria | 1 | CTD_human |
| Tgene | ALOX5 | C0376618 | Endotoxemia | 1 | CTD_human |
| Tgene | ALOX5 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|