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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22401

FusionGeneSummary for MPRIP_SREBF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MPRIP_SREBF1
Fusion gene ID: 22401
HgeneTgene
Gene symbol

MPRIP

SREBF1

Gene ID

23164

6720

Gene namemyosin phosphatase Rho interacting proteinsterol regulatory element binding transcription factor 1
SynonymsM-RIP|MRIP|RHOIP3|RIP3|p116RipSREBP1|bHLHd1
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionmyosin phosphatase Rho-interacting proteinRho interacting protein 3sterol regulatory element-binding protein 1class D basic helix-loop-helix protein 1
Modification date2018052220180522
UniProtAcc

Q6WCQ1

P36956

Ensembl transtripts involved in fusion geneENST00000395811, ENST00000444976, 
ENST00000395804, ENST00000341712, 
ENST00000395806, ENST00000395807, 
ENST00000338854, ENST00000395757, 
ENST00000355815, ENST00000261646, 
ENST00000435530, ENST00000583732, 
Fusion gene scores* DoF score12 X 5 X 7=4205 X 4 X 4=80
# samples 125
** MAII scorelog2(12/420*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPRIP [Title/Abstract] AND SREBF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSREBF1

GO:0045944

positive regulation of transcription by RNA polymerase II

26437365


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-35-5375-01AMPRIPchr17

16946285

+SREBF1chr17

17723835

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000395811ENST00000338854MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395811ENST00000395757MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395811ENST00000355815MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395811ENST00000261646MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395811ENST00000435530MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-5UTRENST00000395811ENST00000583732MPRIPchr17

16946285

+SREBF1chr17

17723835

-
Frame-shitENST00000444976ENST00000338854MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000444976ENST00000395757MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000444976ENST00000355815MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000444976ENST00000261646MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000444976ENST00000435530MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-5UTRENST00000444976ENST00000583732MPRIPchr17

16946285

+SREBF1chr17

17723835

-
Frame-shitENST00000395804ENST00000338854MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395804ENST00000395757MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395804ENST00000355815MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395804ENST00000261646MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395804ENST00000435530MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-5UTRENST00000395804ENST00000583732MPRIPchr17

16946285

+SREBF1chr17

17723835

-
Frame-shitENST00000341712ENST00000338854MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000341712ENST00000395757MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000341712ENST00000355815MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000341712ENST00000261646MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000341712ENST00000435530MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-5UTRENST00000341712ENST00000583732MPRIPchr17

16946285

+SREBF1chr17

17723835

-
Frame-shitENST00000395806ENST00000338854MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395806ENST00000395757MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395806ENST00000355815MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395806ENST00000261646MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-intronENST00000395806ENST00000435530MPRIPchr17

16946285

+SREBF1chr17

17723835

-
5CDS-5UTRENST00000395806ENST00000583732MPRIPchr17

16946285

+SREBF1chr17

17723835

-
3UTR-3CDSENST00000395807ENST00000338854MPRIPchr17

16946285

+SREBF1chr17

17723835

-
3UTR-intronENST00000395807ENST00000395757MPRIPchr17

16946285

+SREBF1chr17

17723835

-
3UTR-intronENST00000395807ENST00000355815MPRIPchr17

16946285

+SREBF1chr17

17723835

-
3UTR-intronENST00000395807ENST00000261646MPRIPchr17

16946285

+SREBF1chr17

17723835

-
3UTR-intronENST00000395807ENST00000435530MPRIPchr17

16946285

+SREBF1chr17

17723835

-
3UTR-5UTRENST00000395807ENST00000583732MPRIPchr17

16946285

+SREBF1chr17

17723835

-

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FusionProtFeatures for MPRIP_SREBF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPRIP

Q6WCQ1

SREBF1

P36956

Targets myosin phosphatase to the actin cytoskeleton.Required for the regulation of the actin cytoskeleton by RhoA andROCK1. Depletion leads to an increased number of stress fibers insmooth muscle cells through stabilization of actin fibers byphosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers inneuronal cells. {ECO:0000250|UniProtKB:P97434,ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPRIP_SREBF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPRIP_SREBF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPRIPPPP1R12C, YWHAB, YWHAG, YWHAQ, SFN, RHOA, ATXN7, ARRB1, FBXO25, LRRK2, NOS3, AGAP2, PAN2, IKBKG, RACGAP1, PIAS4, LSM8, YTHDC1, RPA3, RPA2, RPA1, CCDC101, WDR83, PSAT1, TCP10L2, PSMC3, FNDC4, PACSIN2, ZFP41, PTEN, PCM1, RPGRIP1L, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO19, MYO18A, ESR1, ARMC7, CDH1, VAPB, BTRC, JPH4, VAPA, PACSIN1, PLK1, VTN, NECAB1, CTAGE5, TRIM25SREBF1LMNA, TWIST2, UBE2I, CREBBP, YY1, SP1, NR0B1, MAPK3, MAPK1, FBXW7, KLF13, EP300, AR, MED15, MED23, MED7, MED13, MED12, MED1, MED14, MED24, MED26, MED6, HNF4A, TRRAP, KAT2A, ATM, GCN1L1, TADA2B, TADA3, RUVBL2, SIRT1, MED25, MED17, MED21, CDK8, USF1, GSK3B, ZBTB7C, SREBF2, SREBF1, ZBTB7A, SCAP, INSIG1, INSIG2, EGF, ATXN1, ATXN1L, HSP90AA1, SMARCD3, ERLIN2, KLF5, ID2, ID3, PRMT5, PVALB, SORL1, MTNR1B, PLK1, TRIM25, POLR2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPRIP_SREBF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPRIP_SREBF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPRIPC0043094Weight Gain1CTD_human
TgeneSREBF1C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneSREBF1C0400966Non-alcoholic Fatty Liver Disease2CTD_human
TgeneSREBF1C2239176Liver carcinoma2CTD_human
TgeneSREBF1C0015695Fatty Liver1CTD_human
TgeneSREBF1C0021655Insulin Resistance1CTD_human
TgeneSREBF1C0022661Kidney Failure, Chronic1CTD_human
TgeneSREBF1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSREBF1C0028754Obesity1CTD_human
TgeneSREBF1C0036341Schizophrenia1PSYGENET