FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22399

FusionGeneSummary for MPRIP_P4HA1

check button Fusion gene summary
Fusion gene informationFusion gene name: MPRIP_P4HA1
Fusion gene ID: 22399
HgeneTgene
Gene symbol

MPRIP

P4HA1

Gene ID

23164

5033

Gene namemyosin phosphatase Rho interacting proteinprolyl 4-hydroxylase subunit alpha 1
SynonymsM-RIP|MRIP|RHOIP3|RIP3|p116RipP4HA
Cytomap

17p11.2

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionmyosin phosphatase Rho-interacting proteinRho interacting protein 3prolyl 4-hydroxylase subunit alpha-1C-P4Halpha(I)collagen prolyl 4-hydroxylase alpha(I)procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide Iprocollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1proly
Modification date2018052220180523
UniProtAcc

Q6WCQ1

P13674

Ensembl transtripts involved in fusion geneENST00000395811, ENST00000444976, 
ENST00000395804, ENST00000341712, 
ENST00000395806, ENST00000395807, 
ENST00000307116, ENST00000373008, 
ENST00000263556, ENST00000412021, 
ENST00000440381, ENST00000394890, 
Fusion gene scores* DoF score12 X 5 X 7=4202 X 1 X 2=4
# samples 122
** MAII scorelog2(12/420*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: MPRIP [Title/Abstract] AND P4HA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FW-A3TU-06AMPRIPchr17

16946285

+P4HA1chr10

74790128

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000395811ENST00000307116MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395811ENST00000373008MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395811ENST00000263556MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395811ENST00000412021MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395811ENST00000440381MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395811ENST00000394890MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000444976ENST00000307116MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000444976ENST00000373008MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000444976ENST00000263556MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000444976ENST00000412021MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000444976ENST00000440381MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000444976ENST00000394890MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395804ENST00000307116MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395804ENST00000373008MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395804ENST00000263556MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395804ENST00000412021MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395804ENST00000440381MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395804ENST00000394890MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000341712ENST00000307116MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000341712ENST00000373008MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000341712ENST00000263556MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000341712ENST00000412021MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000341712ENST00000440381MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000341712ENST00000394890MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395806ENST00000307116MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395806ENST00000373008MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395806ENST00000263556MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395806ENST00000412021MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395806ENST00000440381MPRIPchr17

16946285

+P4HA1chr10

74790128

-
Frame-shiftENST00000395806ENST00000394890MPRIPchr17

16946285

+P4HA1chr10

74790128

-
3UTR-3CDSENST00000395807ENST00000307116MPRIPchr17

16946285

+P4HA1chr10

74790128

-
3UTR-3CDSENST00000395807ENST00000373008MPRIPchr17

16946285

+P4HA1chr10

74790128

-
3UTR-3CDSENST00000395807ENST00000263556MPRIPchr17

16946285

+P4HA1chr10

74790128

-
3UTR-3CDSENST00000395807ENST00000412021MPRIPchr17

16946285

+P4HA1chr10

74790128

-
3UTR-3CDSENST00000395807ENST00000440381MPRIPchr17

16946285

+P4HA1chr10

74790128

-
3UTR-3CDSENST00000395807ENST00000394890MPRIPchr17

16946285

+P4HA1chr10

74790128

-

Top

FusionProtFeatures for MPRIP_P4HA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPRIP

Q6WCQ1

P4HA1

P13674

Targets myosin phosphatase to the actin cytoskeleton.Required for the regulation of the actin cytoskeleton by RhoA andROCK1. Depletion leads to an increased number of stress fibers insmooth muscle cells through stabilization of actin fibers byphosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers inneuronal cells. {ECO:0000250|UniProtKB:P97434,ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and otherproteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MPRIP_P4HA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MPRIP_P4HA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPRIPPPP1R12C, YWHAB, YWHAG, YWHAQ, SFN, RHOA, ATXN7, ARRB1, FBXO25, LRRK2, NOS3, AGAP2, PAN2, IKBKG, RACGAP1, PIAS4, LSM8, YTHDC1, RPA3, RPA2, RPA1, CCDC101, WDR83, PSAT1, TCP10L2, PSMC3, FNDC4, PACSIN2, ZFP41, PTEN, PCM1, RPGRIP1L, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO19, MYO18A, ESR1, ARMC7, CDH1, VAPB, BTRC, JPH4, VAPA, PACSIN1, PLK1, VTN, NECAB1, CTAGE5, TRIM25P4HA1MYC, SMN1, IRF7, CDK9, ELAVL1, CUL3, UBL4A, CFTR, HDAC10, WWOX, IRS4, AATK, TSC22D4, EVPL, P4HB, PSMD5, TCTN3, TCTN1, RBM8A, RNF41, CPSF3, SLAIN2, UBA5, FIP1L1, PARD6B, ZNF526, GLI1, FOXA3, FOXG1, FOXL2, FOXP3, FOXS1, CTDSP2, COLQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MPRIP_P4HA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneP4HA1P13674DB01275HydralazineProlyl 4-hydroxylase subunit alpha-1small moleculeapproved
TgeneP4HA1P13674DB00126Vitamin CProlyl 4-hydroxylase subunit alpha-1small moleculeapproved|nutraceutical

Top

RelatedDiseases for MPRIP_P4HA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPRIPC0043094Weight Gain1CTD_human