|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22395 |
FusionGeneSummary for MPRIP_HOXB13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPRIP_HOXB13 | Fusion gene ID: 22395 | Hgene | Tgene | Gene symbol | MPRIP | HOXB13 | Gene ID | 23164 | 10481 |
| Gene name | myosin phosphatase Rho interacting protein | homeobox B13 | |
| Synonyms | M-RIP|MRIP|RHOIP3|RIP3|p116Rip | PSGD | |
| Cytomap | 17p11.2 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin phosphatase Rho-interacting proteinRho interacting protein 3 | homeobox protein Hox-B13 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q6WCQ1 | Q92826 | |
| Ensembl transtripts involved in fusion gene | ENST00000395811, ENST00000444976, ENST00000395804, ENST00000341712, ENST00000395806, ENST00000395807, | ENST00000290295, | |
| Fusion gene scores | * DoF score | 12 X 5 X 7=420 | 1 X 1 X 1=1 |
| # samples | 12 | 1 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MPRIP [Title/Abstract] AND HOXB13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HOXB13 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15126340 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-N8-A4PQ-01A | MPRIP | chr17 | 16981390 | + | HOXB13 | chr17 | 46804405 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000395811 | ENST00000290295 | MPRIP | chr17 | 16981390 | + | HOXB13 | chr17 | 46804405 | - |
| Frame-shift | ENST00000444976 | ENST00000290295 | MPRIP | chr17 | 16981390 | + | HOXB13 | chr17 | 46804405 | - |
| Frame-shift | ENST00000395804 | ENST00000290295 | MPRIP | chr17 | 16981390 | + | HOXB13 | chr17 | 46804405 | - |
| Frame-shift | ENST00000341712 | ENST00000290295 | MPRIP | chr17 | 16981390 | + | HOXB13 | chr17 | 46804405 | - |
| intron-3CDS | ENST00000395806 | ENST00000290295 | MPRIP | chr17 | 16981390 | + | HOXB13 | chr17 | 46804405 | - |
| 3UTR-3CDS | ENST00000395807 | ENST00000290295 | MPRIP | chr17 | 16981390 | + | HOXB13 | chr17 | 46804405 | - |
Top |
FusionProtFeatures for MPRIP_HOXB13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPRIP | HOXB13 |
| Targets myosin phosphatase to the actin cytoskeleton.Required for the regulation of the actin cytoskeleton by RhoA andROCK1. Depletion leads to an increased number of stress fibers insmooth muscle cells through stabilization of actin fibers byphosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers inneuronal cells. {ECO:0000250|UniProtKB:P97434,ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. | Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis.Binds preferentially to methylated DNA (PubMed:28473536).{ECO:0000269|PubMed:28473536}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MPRIP_HOXB13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MPRIP_HOXB13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MPRIP | PPP1R12C, YWHAB, YWHAG, YWHAQ, SFN, RHOA, ATXN7, ARRB1, FBXO25, LRRK2, NOS3, AGAP2, PAN2, IKBKG, RACGAP1, PIAS4, LSM8, YTHDC1, RPA3, RPA2, RPA1, CCDC101, WDR83, PSAT1, TCP10L2, PSMC3, FNDC4, PACSIN2, ZFP41, PTEN, PCM1, RPGRIP1L, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO19, MYO18A, ESR1, ARMC7, CDH1, VAPB, BTRC, JPH4, VAPA, PACSIN1, PLK1, VTN, NECAB1, CTAGE5, TRIM25 | HOXB13 | ELK1, HOXD4, IRF4, POU2F1, ZNF490, ALX4, EED, RNF2, TEAD2, FOXA2, FOXC2, FOXE1, FOXF1, FOXG1, FOXS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MPRIP_HOXB13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MPRIP_HOXB13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MPRIP | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | HOXB13 | C0033578 | Prostatic Neoplasms | 4 | CTD_human |
| Tgene | HOXB13 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | HOXB13 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | HOXB13 | C0376358 | Malignant neoplasm of prostate | 1 | UNIPROT |
| Tgene | HOXB13 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | HOXB13 | C2931456 | Prostate cancer, familial | 1 | CTD_human;ORPHANET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|