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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22383

FusionGeneSummary for MPP6_MPP6

check button Fusion gene summary
Fusion gene informationFusion gene name: MPP6_MPP6
Fusion gene ID: 22383
HgeneTgene
Gene symbol

MPP6

MPP6

Gene ID

51678

51678

Gene namemembrane palmitoylated protein 6membrane palmitoylated protein 6
SynonymsPALS2|VAM-1|VAM1|p55TPALS2|VAM-1|VAM1|p55T
Cytomap

7p15.3

7p15.3

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 6MAGUK protein p55TVELI-associated MAGUK 1membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)protein associated with Lin7 2MAGUK p55 subfamily member 6MAGUK protein p55TVELI-associated MAGUK 1membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)protein associated with Lin7 2
Modification date2018052220180522
UniProtAcc

Q9NZW5

Q9NZW5

Ensembl transtripts involved in fusion geneENST00000222644, ENST00000409761, 
ENST00000396475, 
ENST00000222644, 
ENST00000409761, ENST00000396475, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 2=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MPP6 [Title/Abstract] AND MPP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DW419199MPP6chr7

24708279

+MPP6chr7

24663282

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000222644ENST00000222644MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-intronENST00000222644ENST00000409761MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-5UTRENST00000222644ENST00000396475MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-5UTRENST00000409761ENST00000222644MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-intronENST00000409761ENST00000409761MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-5UTRENST00000409761ENST00000396475MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-5UTRENST00000396475ENST00000222644MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-intronENST00000396475ENST00000409761MPP6chr7

24708279

+MPP6chr7

24663282

+
5CDS-5UTRENST00000396475ENST00000396475MPP6chr7

24708279

+MPP6chr7

24663282

+

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FusionProtFeatures for MPP6_MPP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPP6

Q9NZW5

MPP6

Q9NZW5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPP6_MPP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPP6_MPP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPP6FTL, THOP1, EIF3G, ARHGAP18, KNSTRN, EXOSC10, SNX9, SKIV2L2, AATF, KCNJ12, LIN7A, OPTN, SSTR3, KHDRBS1, DYNLRB1, RPS20, SMARCA4, DNM2, PARN, NDN, NFKB1, MT2P1, FAM188A, LIPT1, P2RY12, LIN7C, NTRK1, NF2, NSUN2, MPP2, SLC20A1, CDA, NAT9, CYP2S1, DMD, FAM19A3MPP6FTL, THOP1, EIF3G, ARHGAP18, KNSTRN, EXOSC10, SNX9, SKIV2L2, AATF, KCNJ12, LIN7A, OPTN, SSTR3, KHDRBS1, DYNLRB1, RPS20, SMARCA4, DNM2, PARN, NDN, NFKB1, MT2P1, FAM188A, LIPT1, P2RY12, LIN7C, NTRK1, NF2, NSUN2, MPP2, SLC20A1, CDA, NAT9, CYP2S1, DMD, FAM19A3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPP6_MPP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPP6_MPP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource