FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22382

FusionGeneSummary for MPP6_HIBADH

check button Fusion gene summary
Fusion gene informationFusion gene name: MPP6_HIBADH
Fusion gene ID: 22382
HgeneTgene
Gene symbol

MPP6

HIBADH

Gene ID

51678

11112

Gene namemembrane palmitoylated protein 63-hydroxyisobutyrate dehydrogenase
SynonymsPALS2|VAM-1|VAM1|p55TNS5ATP1
Cytomap

7p15.3

7p15.2

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 6MAGUK protein p55TVELI-associated MAGUK 1membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)protein associated with Lin7 23-hydroxyisobutyrate dehydrogenase, mitochondrial3'-hydroxyisobutyrate dehydrogenase
Modification date2018052220180523
UniProtAcc

Q9NZW5

P31937

Ensembl transtripts involved in fusion geneENST00000222644, ENST00000409761, 
ENST00000396475, 
ENST00000265395, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 5 X 5=175
# samples 37
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPP6 [Title/Abstract] AND HIBADH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHIBADH

GO:0006574

valine catabolic process

16466957


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-FS-A1ZE-06AMPP6chr7

24720139

+HIBADHchr7

27689242

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000222644ENST00000265395MPP6chr7

24720139

+HIBADHchr7

27689242

-
Frame-shiftENST00000409761ENST00000265395MPP6chr7

24720139

+HIBADHchr7

27689242

-
Frame-shiftENST00000396475ENST00000265395MPP6chr7

24720139

+HIBADHchr7

27689242

-

Top

FusionProtFeatures for MPP6_HIBADH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPP6

Q9NZW5

HIBADH

P31937


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MPP6_HIBADH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MPP6_HIBADH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPP6FTL, THOP1, EIF3G, ARHGAP18, KNSTRN, EXOSC10, SNX9, SKIV2L2, AATF, KCNJ12, LIN7A, OPTN, SSTR3, KHDRBS1, DYNLRB1, RPS20, SMARCA4, DNM2, PARN, NDN, NFKB1, MT2P1, FAM188A, LIPT1, P2RY12, LIN7C, NTRK1, NF2, NSUN2, MPP2, SLC20A1, CDA, NAT9, CYP2S1, DMD, FAM19A3HIBADHHIBADH, TRIM63, ELAVL1, BRCA1, ALDH1B1, ALDH6A1, MDH1, PDXK, SOD1, ZNF692


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MPP6_HIBADH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MPP6_HIBADH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource