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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22378

FusionGeneSummary for MPP5_RAD51B

check button Fusion gene summary
Fusion gene informationFusion gene name: MPP5_RAD51B
Fusion gene ID: 22378
HgeneTgene
Gene symbol

MPP5

RAD51B

Gene ID

64398

5890

Gene namemembrane palmitoylated protein 5RAD51 paralog B
SynonymsPALS1R51H2|RAD51L1|REC2
Cytomap

14q23.3

14q24.1

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)protein associated with Lin-7 1protein associated with lin seven 1stardustDNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2018051920180523
UniProtAcc

Q8N3R9

O15315

Ensembl transtripts involved in fusion geneENST00000261681, ENST00000555925, 
ENST00000554911, ENST00000556345, 
ENST00000487861, ENST00000471583, 
ENST00000487270, ENST00000488612, 
ENST00000390683, ENST00000469165, 
Fusion gene scores* DoF score8 X 8 X 10=64025 X 15 X 8=3000
# samples 1733
** MAII scorelog2(17/640*10)=-1.91253715874966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3000*10)=-3.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPP5 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0ES-01AMPP5chr14

67779427

+RAD51Bchr14

69196525

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261681ENST00000487861MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000261681ENST00000471583MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000261681ENST00000487270MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-3UTRENST00000261681ENST00000488612MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000261681ENST00000390683MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000261681ENST00000469165MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000555925ENST00000487861MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000555925ENST00000471583MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000555925ENST00000487270MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-3UTRENST00000555925ENST00000488612MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000555925ENST00000390683MPP5chr14

67779427

+RAD51Bchr14

69196525

+
5CDS-intronENST00000555925ENST00000469165MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000554911ENST00000487861MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000554911ENST00000471583MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000554911ENST00000487270MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-3UTRENST00000554911ENST00000488612MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000554911ENST00000390683MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000554911ENST00000469165MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000556345ENST00000487861MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000556345ENST00000471583MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000556345ENST00000487270MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-3UTRENST00000556345ENST00000488612MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000556345ENST00000390683MPP5chr14

67779427

+RAD51Bchr14

69196525

+
intron-intronENST00000556345ENST00000469165MPP5chr14

67779427

+RAD51Bchr14

69196525

+

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FusionProtFeatures for MPP5_RAD51B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPP5

Q8N3R9

RAD51B

O15315

May play a role in tight junctions biogenesis and in theestablishment of cell polarity in epithelial cells. May modulateSC6A1/GAT1-mediated GABA uptake by stabilizing the transporter.Required for localization of EZR to the apical membrane ofparietal cells and may play a role in the dynamic remodeling ofthe apical cytoskeleton (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPP5_RAD51B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPP5_RAD51B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPP5INADL, PARD6A, AMOT, ARHGAP17, LIN7A, ZNF451, AMOTL2, LATS1, LATS2, YAP1, WWOX, LIN7C, AMOTL1, MPDZ, SOCS4, CEP128, NINL, RPH3A, LIN7B, HOMER3, ALOX5, PCDHAC2, RNF19B, SH3KBP1, GAK, STXBP4, WWC1RAD51BRAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPP5_RAD51B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPP5_RAD51B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAD51BC0236969Substance-Related Disorders1CTD_human
TgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
TgeneRAD51BC1458155Mammary Neoplasms1CTD_human