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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22372

FusionGeneSummary for MPP1_MPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MPP1_MPP1
Fusion gene ID: 22372
HgeneTgene
Gene symbol

MPP1

MPP1

Gene ID

9585

9585

Gene namekinesin family member 20Bkinesin family member 20B
SynonymsCT90|KRMP1|MPHOSPH1|MPP-1|MPP1CT90|KRMP1|MPHOSPH1|MPP-1|MPP1
Cytomap

10q23.31

10q23.31

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF20BM-phase phosphoprotein 1cancer/testis antigen 90kinesin-related motor interacting with PIN1mitotic kinesin-like proteinmitotic kinesin-related proteinkinesin-like protein KIF20BM-phase phosphoprotein 1cancer/testis antigen 90kinesin-related motor interacting with PIN1mitotic kinesin-like proteinmitotic kinesin-related protein
Modification date2018052320180523
UniProtAcc

Q00013

Q00013

Ensembl transtripts involved in fusion geneENST00000369534, ENST00000413259, 
ENST00000393531, ENST00000462825, 
ENST00000369534, ENST00000413259, 
ENST00000393531, ENST00000462825, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: MPP1 [Title/Abstract] AND MPP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF086593MPP1chrX

154007316

+MPP1chrX

154007106

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000369534ENST00000369534MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-3UTRENST00000369534ENST00000413259MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000369534ENST00000393531MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000369534ENST00000462825MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-3UTRENST00000413259ENST00000369534MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-3UTRENST00000413259ENST00000413259MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000413259ENST00000393531MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000413259ENST00000462825MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-3UTRENST00000393531ENST00000369534MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-3UTRENST00000393531ENST00000413259MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000393531ENST00000393531MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000393531ENST00000462825MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-3UTRENST00000462825ENST00000369534MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-3UTRENST00000462825ENST00000413259MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000462825ENST00000393531MPP1chrX

154007316

+MPP1chrX

154007106

-
intron-intronENST00000462825ENST00000462825MPP1chrX

154007316

+MPP1chrX

154007106

-

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FusionProtFeatures for MPP1_MPP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPP1

Q00013

MPP1

Q00013

Essential regulator of neutrophil polarity. Regulatesneutrophil polarization by regulating AKT1 phosphorylation througha mechanism that is independent of PIK3CG activity (Bysimilarity). {ECO:0000250}. Essential regulator of neutrophil polarity. Regulatesneutrophil polarization by regulating AKT1 phosphorylation througha mechanism that is independent of PIK3CG activity (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPP1_MPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPP1_MPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPP1_MPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPP1_MPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPP1C0001418Adenocarcinoma1CTD_human
HgeneMPP1C0024121Lung Neoplasms1CTD_human
TgeneMPP1C0001418Adenocarcinoma1CTD_human
TgeneMPP1C0024121Lung Neoplasms1CTD_human