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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22371

FusionGeneSummary for MPO_TYK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MPO_TYK2
Fusion gene ID: 22371
HgeneTgene
Gene symbol

MPO

TYK2

Gene ID

4353

7297

Gene namemyeloperoxidasetyrosine kinase 2
Synonyms-IMD35|JTK1
Cytomap

17q22

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionmyeloperoxidasenon-receptor tyrosine-protein kinase TYK2
Modification date2018052320180522
UniProtAcc

P05164

P29597

Ensembl transtripts involved in fusion geneENST00000340482, ENST00000225275, 
ENST00000578493, 
ENST00000264818, 
ENST00000524462, ENST00000525621, 
ENST00000529370, ENST00000529422, 
Fusion gene scores* DoF score7 X 4 X 2=5642 X 7 X 17=4998
# samples 643
** MAII scorelog2(6/56*10)=0.0995356735509144
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(43/4998*10)=-3.53894233649724
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPO [Title/Abstract] AND TYK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMPO

GO:0034374

low-density lipoprotein particle remodeling

10772654

HgeneMPO

GO:0042744

hydrogen peroxide catabolic process

10772654|11907569

HgeneMPO

GO:0055114

oxidation-reduction process

10772654


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLAMLTCGA-AB-2857-03AMPOchr17

56347217

-TYK2chr19

10491352

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340482ENST00000264818MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000340482ENST00000524462MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000340482ENST00000525621MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000340482ENST00000529370MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000340482ENST00000529422MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000225275ENST00000264818MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000225275ENST00000524462MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000225275ENST00000525621MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000225275ENST00000529370MPOchr17

56347217

-TYK2chr19

10491352

-
5CDS-intronENST00000225275ENST00000529422MPOchr17

56347217

-TYK2chr19

10491352

-
intron-intronENST00000578493ENST00000264818MPOchr17

56347217

-TYK2chr19

10491352

-
intron-intronENST00000578493ENST00000524462MPOchr17

56347217

-TYK2chr19

10491352

-
intron-intronENST00000578493ENST00000525621MPOchr17

56347217

-TYK2chr19

10491352

-
intron-intronENST00000578493ENST00000529370MPOchr17

56347217

-TYK2chr19

10491352

-
intron-intronENST00000578493ENST00000529422MPOchr17

56347217

-TYK2chr19

10491352

-

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FusionProtFeatures for MPO_TYK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPO

P05164

TYK2

P29597

Part of the host defense system of polymorphonuclearleukocytes. It is responsible for microbicidal activity against awide range of organisms. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid inphysiologic situations, and other toxic intermediates that greatlyenhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}. Probably involved in intracellular signal transductionby being involved in the initiation of type I IFN signaling.Phosphorylates the interferon-alpha/beta receptor alpha chain.{ECO:0000269|PubMed:7526154}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPO_TYK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPO_TYK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPORAD21, ICE2, FRMD1, APCDD1, PLB1TYK2GNB2L1, STAT1, PRMT5, XRCC5, VAV1, IFNAR1, CRKL, JAK1, TYK2, ELP2, IL13RA1, LYN, CBL, PTPN6, PLAUR, IL6ST, FYN, PTPN1, STAM2, GHR, IRS2, DNM2, TK1, SOCS1, KLF10, LNX1, PTAFR, EIF2AK2, HSP90AA1, JAK3, COPS5, FHL3, HNRNPK, TRAF4, KRT40, KHDRBS2, SIVA1, SHMT2, MOV10, NXF1, BAG2, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, DDX5, HNRNPH1, HSPB1, CEP170B, RAN, RUVBL1, RUVBL2, SLC2A1, TCP1, ALYREF, TRIM28, TUBA4A, WDR20, EFNB2, PIH1D1, TGFBR2, LRRC46, LPAR6, RNF13, ZNF333, MIER2, SIAH2, UBE2L6, LRP8, IFT43, PMEL, TNFRSF19, GMNN, IL4R, TMCO3, GPR156, CDH8, CD79A, TNFRSF13B, HAVCR2, PROSER2, LGALS3BP, C16orf71, MAS1, NLGN3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPO_TYK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMPOP05164DB00244MesalazineMyeloperoxidasesmall moleculeapproved
HgeneMPOP05164DB00535CefdinirMyeloperoxidasesmall moleculeapproved
HgeneMPOP05164DB00583L-CarnitineMyeloperoxidasesmall moleculeapproved|investigational
HgeneMPOP05164DB01065MelatoninMyeloperoxidasesmall moleculeapproved|nutraceutical|vet_approved
TgeneTYK2P29597DB08895TofacitinibNon-receptor tyrosine-protein kinase TYK2small moleculeapproved|investigational

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RelatedDiseases for MPO_TYK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPOC0035126Reperfusion Injury6CTD_human
HgeneMPOC0021368Inflammation5CTD_human
HgeneMPOC0009324Ulcerative Colitis3CTD_human
HgeneMPOC0398595Myeloperoxidase Deficiency3CTD_human;ORPHANET;UNIPROT
HgeneMPOC0003873Rheumatoid Arthritis2CTD_human
HgeneMPOC0023891Liver Cirrhosis, Alcoholic2CTD_human
HgeneMPOC0001969Alcoholic Intoxication1PSYGENET
HgeneMPOC0002395Alzheimer's Disease1CTD_human
HgeneMPOC0005695Bladder Neoplasm1CTD_human
HgeneMPOC0006111Brain Diseases1CTD_human
HgeneMPOC0007222Cardiovascular Diseases1CTD_human
HgeneMPOC0007786Brain Ischemia1CTD_human
HgeneMPOC0009319Colitis1CTD_human
HgeneMPOC0011609Drug Eruptions1CTD_human
HgeneMPOC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneMPOC0022593Keratosis1CTD_human
HgeneMPOC0022658Kidney Diseases1CTD_human
HgeneMPOC0024115Lung diseases1CTD_human
HgeneMPOC0024121Lung Neoplasms1CTD_human
HgeneMPOC0028797Occupational Diseases1CTD_human
HgeneMPOC0030305Pancreatitis1CTD_human
HgeneMPOC0032927Precancerous Conditions1CTD_human
HgeneMPOC0033578Prostatic Neoplasms1CTD_human
HgeneMPOC0036982Shock, Hemorrhagic1CTD_human
HgeneMPOC0040954Infection by Trichuris trichiura1CTD_human
HgeneMPOC0042109Urticaria1CTD_human
HgeneMPOC0242184Hypoxia1CTD_human
HgeneMPOC0993582Arthritis, Experimental1CTD_human
HgeneMPOC1269683Major Depressive Disorder1CTD_human
HgeneMPOC2239176Liver carcinoma1CTD_human
HgeneMPOC2609414Acute kidney injury1CTD_human
TgeneTYK2C0003873Rheumatoid Arthritis1CTD_human
TgeneTYK2C0010346Crohn Disease1CTD_human
TgeneTYK2C0023892Biliary cirrhosis1CTD_human
TgeneTYK2C0026769Multiple Sclerosis1CTD_human
TgeneTYK2C0033860Psoriasis1CTD_human
TgeneTYK2C0041696Unipolar Depression1PSYGENET
TgeneTYK2C0236736Cocaine-Related Disorders1CTD_human
TgeneTYK2C0344315Depressed mood1PSYGENET
TgeneTYK2C1269683Major Depressive Disorder1PSYGENET
TgeneTYK2C1456784Paranoia1CTD_human