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Fusion gene ID: 22367 |
FusionGeneSummary for MPO_FAR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPO_FAR1 | Fusion gene ID: 22367 | Hgene | Tgene | Gene symbol | MPO | FAR1 | Gene ID | 4353 | 84188 |
| Gene name | myeloperoxidase | fatty acyl-CoA reductase 1 | |
| Synonyms | - | MLSTD2|PFCRD|SDR10E1 | |
| Cytomap | 17q22 | 11p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myeloperoxidase | fatty acyl-CoA reductase 1male sterility domain-containing protein 2short chain dehydrogenase/reductase family 10E, member 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P05164 | Q8WVX9 | |
| Ensembl transtripts involved in fusion gene | ENST00000340482, ENST00000225275, ENST00000578493, | ENST00000354817, ENST00000527202, ENST00000532502, | |
| Fusion gene scores | * DoF score | 7 X 4 X 2=56 | 28 X 8 X 12=2688 |
| # samples | 6 | 31 | |
| ** MAII score | log2(6/56*10)=0.0995356735509144 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(31/2688*10)=-3.11619301750452 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MPO [Title/Abstract] AND FAR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MPO | GO:0034374 | low-density lipoprotein particle remodeling | 10772654 |
| Hgene | MPO | GO:0042744 | hydrogen peroxide catabolic process | 10772654|11907569 |
| Hgene | MPO | GO:0055114 | oxidation-reduction process | 10772654 |
| Tgene | FAR1 | GO:0008611 | ether lipid biosynthetic process | 24108123 |
| Tgene | FAR1 | GO:0035336 | long-chain fatty-acyl-CoA metabolic process | 15220348 |
| Tgene | FAR1 | GO:0046474 | glycerophospholipid biosynthetic process | 20071337 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LAML | TCGA-AB-2846-03A | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000340482 | ENST00000354817 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| 5CDS-intron | ENST00000340482 | ENST00000527202 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| 5CDS-intron | ENST00000340482 | ENST00000532502 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| 5CDS-intron | ENST00000225275 | ENST00000354817 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| 5CDS-intron | ENST00000225275 | ENST00000527202 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| 5CDS-intron | ENST00000225275 | ENST00000532502 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| intron-intron | ENST00000578493 | ENST00000354817 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| intron-intron | ENST00000578493 | ENST00000527202 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
| intron-intron | ENST00000578493 | ENST00000532502 | MPO | chr17 | 56347217 | - | FAR1 | chr11 | 13744912 | + |
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FusionProtFeatures for MPO_FAR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPO | FAR1 |
| Part of the host defense system of polymorphonuclearleukocytes. It is responsible for microbicidal activity against awide range of organisms. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid inphysiologic situations, and other toxic intermediates that greatlyenhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}. | Catalyzes the reduction of saturated and unsaturated C16or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348,PubMed:24108123). It plays an essential role in the production ofether lipids/plasmalogens which synthesis requires fatty alcohols(PubMed:20071337, PubMed:24108123). In parallel, it is alsorequired for wax monoesters production since fatty alcohols alsoconstitute a substrate for their synthesis (By similarity).{ECO:0000250|UniProtKB:Q922J9, ECO:0000269|PubMed:15220348,ECO:0000269|PubMed:20071337, ECO:0000269|PubMed:24108123}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MPO_FAR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MPO_FAR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MPO | RAD21, ICE2, FRMD1, APCDD1, PLB1 | FAR1 | C20orf24, SLC2A4, CUL3, CUL5, ATXN1, IQCB1, PEX14, CLN3, CCDC8, EGFR, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPO_FAR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MPO | P05164 | DB00244 | Mesalazine | Myeloperoxidase | small molecule | approved |
| Hgene | MPO | P05164 | DB00535 | Cefdinir | Myeloperoxidase | small molecule | approved |
| Hgene | MPO | P05164 | DB00583 | L-Carnitine | Myeloperoxidase | small molecule | approved|investigational |
| Hgene | MPO | P05164 | DB01065 | Melatonin | Myeloperoxidase | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for MPO_FAR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MPO | C0035126 | Reperfusion Injury | 6 | CTD_human |
| Hgene | MPO | C0021368 | Inflammation | 5 | CTD_human |
| Hgene | MPO | C0009324 | Ulcerative Colitis | 3 | CTD_human |
| Hgene | MPO | C0398595 | Myeloperoxidase Deficiency | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | MPO | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
| Hgene | MPO | C0023891 | Liver Cirrhosis, Alcoholic | 2 | CTD_human |
| Hgene | MPO | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| Hgene | MPO | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Hgene | MPO | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | MPO | C0006111 | Brain Diseases | 1 | CTD_human |
| Hgene | MPO | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Hgene | MPO | C0007786 | Brain Ischemia | 1 | CTD_human |
| Hgene | MPO | C0009319 | Colitis | 1 | CTD_human |
| Hgene | MPO | C0011609 | Drug Eruptions | 1 | CTD_human |
| Hgene | MPO | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Hgene | MPO | C0022593 | Keratosis | 1 | CTD_human |
| Hgene | MPO | C0022658 | Kidney Diseases | 1 | CTD_human |
| Hgene | MPO | C0024115 | Lung diseases | 1 | CTD_human |
| Hgene | MPO | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | MPO | C0028797 | Occupational Diseases | 1 | CTD_human |
| Hgene | MPO | C0030305 | Pancreatitis | 1 | CTD_human |
| Hgene | MPO | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | MPO | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | MPO | C0036982 | Shock, Hemorrhagic | 1 | CTD_human |
| Hgene | MPO | C0040954 | Infection by Trichuris trichiura | 1 | CTD_human |
| Hgene | MPO | C0042109 | Urticaria | 1 | CTD_human |
| Hgene | MPO | C0242184 | Hypoxia | 1 | CTD_human |
| Hgene | MPO | C0993582 | Arthritis, Experimental | 1 | CTD_human |
| Hgene | MPO | C1269683 | Major Depressive Disorder | 1 | CTD_human |
| Hgene | MPO | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | MPO | C2609414 | Acute kidney injury | 1 | CTD_human |
| Tgene | FAR1 | C4015344 | PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER | 1 | ORPHANET;UNIPROT |
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