FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22366

FusionGeneSummary for MPO_ANXA1

check button Fusion gene summary
Fusion gene informationFusion gene name: MPO_ANXA1
Fusion gene ID: 22366
HgeneTgene
Gene symbol

MPO

ANXA1

Gene ID

4353

301

Gene namemyeloperoxidaseannexin A1
Synonyms-ANX1|LPC1
Cytomap

17q22

9q21.13

Type of geneprotein-codingprotein-coding
Descriptionmyeloperoxidaseannexin A1annexin I (lipocortin I)annexin-1calpactin IIcalpactin-2chromobindin-9phospholipase A2 inhibitory protein
Modification date2018052320180522
UniProtAcc

P05164

P04083

Ensembl transtripts involved in fusion geneENST00000340482, ENST00000225275, 
ENST00000578493, 
ENST00000257497, 
ENST00000376911, ENST00000491192, 
Fusion gene scores* DoF score7 X 4 X 2=5619 X 2 X 7=266
# samples 619
** MAII scorelog2(6/56*10)=0.0995356735509144
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(19/266*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPO [Title/Abstract] AND ANXA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMPO

GO:0034374

low-density lipoprotein particle remodeling

10772654

HgeneMPO

GO:0042744

hydrogen peroxide catabolic process

10772654|11907569

HgeneMPO

GO:0055114

oxidation-reduction process

10772654

TgeneANXA1

GO:0002548

monocyte chemotaxis

15187149

TgeneANXA1

GO:0007187

G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

25664854

TgeneANXA1

GO:0008360

regulation of cell shape

15187149

TgeneANXA1

GO:0018149

peptide cross-linking

10908733

TgeneANXA1

GO:0030216

keratinocyte differentiation

10908733

TgeneANXA1

GO:0031340

positive regulation of vesicle fusion

2138016

TgeneANXA1

GO:0031532

actin cytoskeleton reorganization

15187149

TgeneANXA1

GO:0032743

positive regulation of interleukin-2 production

17008549

TgeneANXA1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

22773844

TgeneANXA1

GO:0042102

positive regulation of T cell proliferation

17008549

TgeneANXA1

GO:0045627

positive regulation of T-helper 1 cell differentiation

17008549

TgeneANXA1

GO:0045629

negative regulation of T-helper 2 cell differentiation

17008549

TgeneANXA1

GO:0071385

cellular response to glucocorticoid stimulus

2936963

TgeneANXA1

GO:0071621

granulocyte chemotaxis

15187149

TgeneANXA1

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

22773844

TgeneANXA1

GO:0090303

positive regulation of wound healing

25664854


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLAMLTCGA-AB-2994-03AMPOchr17

56347217

-ANXA1chr9

75772570

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340482ENST00000257497MPOchr17

56347217

-ANXA1chr9

75772570

+
5CDS-intronENST00000340482ENST00000376911MPOchr17

56347217

-ANXA1chr9

75772570

+
5CDS-intronENST00000340482ENST00000491192MPOchr17

56347217

-ANXA1chr9

75772570

+
5CDS-intronENST00000225275ENST00000257497MPOchr17

56347217

-ANXA1chr9

75772570

+
5CDS-intronENST00000225275ENST00000376911MPOchr17

56347217

-ANXA1chr9

75772570

+
5CDS-intronENST00000225275ENST00000491192MPOchr17

56347217

-ANXA1chr9

75772570

+
intron-intronENST00000578493ENST00000257497MPOchr17

56347217

-ANXA1chr9

75772570

+
intron-intronENST00000578493ENST00000376911MPOchr17

56347217

-ANXA1chr9

75772570

+
intron-intronENST00000578493ENST00000491192MPOchr17

56347217

-ANXA1chr9

75772570

+

Top

FusionProtFeatures for MPO_ANXA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPO

P05164

ANXA1

P04083

Part of the host defense system of polymorphonuclearleukocytes. It is responsible for microbicidal activity against awide range of organisms. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid inphysiologic situations, and other toxic intermediates that greatlyenhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}. Plays important roles in the innate immune response aseffector of glucocorticoid-mediated responses and regulator of theinflammatory process. Has anti-inflammatory activity(PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (Bysimilarity). Promotes resolution of inflammation and wound healing(PubMed:25664854). Functions at least in part by activating theformyl peptide receptors and downstream signaling cascades(PubMed:15187149, PubMed:25664854). Promotes chemotaxis ofgranulocytes and monocytes via activation of the formyl peptidereceptors (PubMed:15187149). Contributes to the adaptive immuneresponse by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation ofactivated T-cells (PubMed:17008549). Promotes the differentiationof T-cells into Th1 cells and negatively regulates differentiationinto Th2 cells (PubMed:17008549). Has no effect on unstimulated Tcells (PubMed:17008549). Promotes rearrangement of the actincytoskeleton, cell polarization and cell migration(PubMed:15187149). Negatively regulates hormone exocytosis viaactivation of the formyl peptide receptors and reorganization ofthe actin cytoskeleton (PubMed:19625660). Has high affinity forCa(2+) and can bind up to eight Ca(2+) ions (By similarity).Displays Ca(2+)-dependent binding to phospholipid membranes(PubMed:2532504, PubMed:8557678). Plays a role in the formation ofphagocytic cups and phagosomes. Plays a role in phagocytosis bymediating the Ca(2+)-dependent interaction between phagosomes andthe actin cytoskeleton (By similarity).{ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619,ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:17008549,ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504,ECO:0000269|PubMed:25664854, ECO:0000269|PubMed:2936963,ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MPO_ANXA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MPO_ANXA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPORAD21, ICE2, FRMD1, APCDD1, PLB1ANXA1PPM1B, DLG3, S100A11, KRT8, USP25, USPL1, SLX1B, ATG4B, MGMT, UCHL5, UBE3A, CD4, UBE2I, GAPDH, KLHL23, APBB1, CSAD, C1orf123, RPA1, UNC119, OTUB1, C14orf1, XRCC6, KMT2B, CCT7, UBE2D1, COPS6, LRIF1, FAF1, ANXA1, ANXA5, SIRT7, CUL5, CDK2, IKBKG, RIPK1, RELA, ANXA4, FN1, VCAM1, ATF2, ITGA4, HMGA1, BAG3, ATP4A, YWHAQ, HECW2, WWOX, ZBTB1, MEIS2, ENO1, MOV10, NXF1, CUL7, OBSL1, SUMO2, NSL1, UCP2, SOX2, KIR2DS2, DDX19B, UGT1A10, ZSCAN20, TP53BP2, MAP1S, STK4, RASSF10, HNRNPA1, HSPB1, CEP152, CEP128, CEP89, DCTN1, KIF11, PPIA, TFG, GOLT1B, CCDC88A, USP7, MCM2, EGFR, U2AF2, ACTA1, PLA2G4A, CDC73, CDH1, GNB2, FRMD1, RPUSD3, SOD1, TRIM25, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MPO_ANXA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMPOP05164DB00244MesalazineMyeloperoxidasesmall moleculeapproved
HgeneMPOP05164DB00535CefdinirMyeloperoxidasesmall moleculeapproved
HgeneMPOP05164DB00583L-CarnitineMyeloperoxidasesmall moleculeapproved|investigational
HgeneMPOP05164DB01065MelatoninMyeloperoxidasesmall moleculeapproved|nutraceutical|vet_approved
TgeneANXA1P04083DB00288AmcinonideAnnexin A1small moleculeapproved
TgeneANXA1P04083DB01234DexamethasoneAnnexin A1small moleculeapproved|investigational|vet_approved
TgeneANXA1P04083DB00741HydrocortisoneAnnexin A1small moleculeapproved|vet_approved

Top

RelatedDiseases for MPO_ANXA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPOC0035126Reperfusion Injury6CTD_human
HgeneMPOC0021368Inflammation5CTD_human
HgeneMPOC0009324Ulcerative Colitis3CTD_human
HgeneMPOC0398595Myeloperoxidase Deficiency3CTD_human;ORPHANET;UNIPROT
HgeneMPOC0003873Rheumatoid Arthritis2CTD_human
HgeneMPOC0023891Liver Cirrhosis, Alcoholic2CTD_human
HgeneMPOC0001969Alcoholic Intoxication1PSYGENET
HgeneMPOC0002395Alzheimer's Disease1CTD_human
HgeneMPOC0005695Bladder Neoplasm1CTD_human
HgeneMPOC0006111Brain Diseases1CTD_human
HgeneMPOC0007222Cardiovascular Diseases1CTD_human
HgeneMPOC0007786Brain Ischemia1CTD_human
HgeneMPOC0009319Colitis1CTD_human
HgeneMPOC0011609Drug Eruptions1CTD_human
HgeneMPOC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneMPOC0022593Keratosis1CTD_human
HgeneMPOC0022658Kidney Diseases1CTD_human
HgeneMPOC0024115Lung diseases1CTD_human
HgeneMPOC0024121Lung Neoplasms1CTD_human
HgeneMPOC0028797Occupational Diseases1CTD_human
HgeneMPOC0030305Pancreatitis1CTD_human
HgeneMPOC0032927Precancerous Conditions1CTD_human
HgeneMPOC0033578Prostatic Neoplasms1CTD_human
HgeneMPOC0036982Shock, Hemorrhagic1CTD_human
HgeneMPOC0040954Infection by Trichuris trichiura1CTD_human
HgeneMPOC0042109Urticaria1CTD_human
HgeneMPOC0242184Hypoxia1CTD_human
HgeneMPOC0993582Arthritis, Experimental1CTD_human
HgeneMPOC1269683Major Depressive Disorder1CTD_human
HgeneMPOC2239176Liver carcinoma1CTD_human
HgeneMPOC2609414Acute kidney injury1CTD_human
TgeneANXA1C0024667Animal Mammary Neoplasms3CTD_human
TgeneANXA1C0024668Mammary Neoplasms, Experimental2CTD_human
TgeneANXA1C0007137Squamous cell carcinoma1CTD_human
TgeneANXA1C0020538Hypertensive disease1CTD_human
TgeneANXA1C0022658Kidney Diseases1CTD_human
TgeneANXA1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneANXA1C0024232Lymphatic Metastasis1CTD_human
TgeneANXA1C0026640Mouth Neoplasms1CTD_human
TgeneANXA1C0027626Neoplasm Invasiveness1CTD_human
TgeneANXA1C0027627Neoplasm Metastasis1CTD_human
TgeneANXA1C0033578Prostatic Neoplasms1CTD_human
TgeneANXA1C0038354Stomach Diseases1CTD_human
TgeneANXA1C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneANXA1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneANXA1C0376634Craniofacial Abnormalities1CTD_human